GLOSSARY
6-thioguanine
- An oral immunosuppressive medication.
- A commonly used medication for pain (Tylenol™).
Acinus
- The main structural unit of the liver seen under the microscope; each acinus includes liver cells, sinusoids, central and portal areas with blood vessels, lymphatics, and bile ducts.
Acute fatty liver
- Rapid accumulation of fat in the liver usually caused by alcohol or medications that interfere with fat metabolism. Rarely, this can occur in the last trimester of pregnancy.
Acute liver disease
- Liver disease that is limited in duration, but usually with a sudden and symptomatic onset.
Acute liver failure
- Serious liver failure arising suddenly in a person without previous liver disease.
Acute hepatic necrosis
- Sudden severe liver (hepatic) cell death (necrosis) that is typical of toxic injury to the liver.
Adenoma
- A benign tumor of the liver that can grow large and rupture, causing internal bleeding.
Adenoma
- A benign tumor of the liver that can grow large and rupture, causing internal bleeding.
Adenosine triphosphate (ATP)
- The molecule within cells used for energy reactions.
Alanine aminotransferase (ALT)
- An enzyme found in the blood that is elevated with liver injury, particularly hepatocellular (formerly SGPT). This is the most sensitive indicator of injury to the liver.
Alkaline phosphatase (Alk P)
- An enzyme found in the blood that is elevated with liver injury, particularly cholestatic. This enzyme can also originate from other structures, like bone and bowel; if originating from the liver, other enzymes, such as the GGT, ALT, or liver fraction of the alkaline phosphatase will be abnormal.
Allogeneic
- A transplant in which the recipient receives an organ or cells from another (usually related) person.
Aminotransferase
- one of two enzymes (alanine or aspartate aminotransferase: ALT and AST) found in the blood that, when elevated, are sensitive indicators of liver injury.
Amiodarone
- medication used to control the heart rhythm.
Amoxicillin/clavulanate
- A commonly used, oral antibiotic combination (Augmentin™).
Anabolic steroids
- Medications that act similarly to male sex hormones.
Androgenic steroids
- male sex hormones, sometimes called anabolic steroids.
Anicteric
- absence of jaundice [icterus]
Anorexia
- loss of appetite.
Antinuclear antibody
- An antibody found in blood directed against the nucleus of cells, typically present in patients with autoimmune hepatitis.
Antiretroviral
- n antiviral agent used to treat AIDS or HIV infection.
Anti-smooth muscle antibody
- An antibody found in blood directed against smooth muscles, typically present in patients with autoimmune hepatitis.
Apoptosis
- Programmed cell death which is typical of the liver cell injury from hepatitis, as opposed to necrosis which is typical of toxic injury or shock
Aromatic anticonvulsants
- A class of antiepilepsy medications which includes phenytoin.
Ascites
- Accumulation of fluid in the abdominal cavity, which is usually caused by acute or chronic liver failure.
Aspartate aminotransferase (AST)
- An enzyme found in the blood that is elevated with liver injury, particularly hepatocellular (formerly SGOT). Although elevated in liver disease, the enzyme can originate from other organs and muscle.
Asterixis
- A jerking motion of the outstretched hands that is a sign of early stages of liver coma.
Atorvastatin
- A cholesterol lowering drug (statin).
Autoantibodies
- Antibodies in the blood that are directed against normal body proteins or cells, such as antinuclear antibody or anti-smooth muscle antibody.
Autoimmune features
- Findings suggestive of an overactive immune system, such as high antibody levels and "autoantibodies".
Autoimmune hepatitis
- A chronic liver disease in which an overactive immune system appears to damage the liver.
Autologous
- A transplant in which the recipient receives his/her own organ or cells.
Azathioprine
- A drug used to treat autoimmune diseases, including autoimmune hepatitis .
-
Swelling of liver cells and resultant cell injury that is typical of fatty liver disease as seen under a microscope.
Benign postoperative cholestasis
- Jaundice after major surgery that is temporary and resolves without treatment.
Benzodiazepines
- A class of medications used for treatment of anxiety, insomnia and muscle spasms; examples include diazepam (Valium), midazolam (Versed), alprazolam (Xanax) and others.
Bile ducts
- The small conduits (ducts) in the liver that allow the flow of bile from liver cells out through gradually larger bile ducts into the intestine.
Bilirubin
- The chemical breakdown product of red blood cells that is normally removed by the liver and excreted in bile. Bilirubin can accumulate in the serum and lead to detectable jaundice when there is liver injury and dysfunction, obstruction to the flow of bile, or spontaneous red cell destruction (hemolysis).
Bland cholestasis
- Cholestatic liver injury with minimal or no inflammation in the liver.
Bone marrow transplantation
- Replacement of a person's bone marrow with that of another person, used to treat leukemia and other severe forms of cancer or genetic disease.
Budd-Chiari syndrome
- A severe liver disease caused by clotting and blockage of the large veins that drain the liver.
Busulfan
- An anticancer medication, often used before bone marrow transplantation.
Celandine
- A plant and herbal medication used for treating intestinal complaints.
Celiac disease
- An inherited disease of the small intestine caused by allergy to wheat (gliadin).
Cerebral edema
Cephalosporins
- A large class antibiotics related to penicillin; examples include cephalexin, cefazolin and others.
Chlorpromazine
- A medication used to treat psychosis (also called Thorazine).
Cholangiography
- An X-ray that shows the large bile ducts that drain bile from the liver into the intestine.
Cholecystectomy
- A surgical operation to remove the gallbladder.
Cholecystitis
- Inflammation of the gallbladder, typically causing fever, nausea, and abdominal pain.
Choledocholithiasis
- Gallstones which have passed into the bile ducts.
Cholelithiasis
- Gallstones in the gallbladder.
Cholestatic injury
- Liver injury in which interference with bile flow and jaundice are prominent.
Cholesterol
- The major form of fat in the body, most of which is produced in the liver.
Chronic liver disease
- Persistent, long term liver disease often with vague or mild symptoms and slow onset. Conventionally, disease has been present for more than 6 months.
Chronic liver failure
- Serious liver failure arising gradually in a person with a chronic liver disease.
Ciprofloxacin
- An oral antibiotic.
Cirrhosis
- Scarring and permanent injury to the liver, usually the result of chronic, long term damage.
Clinical phenotype
- A pattern of clinical presentation and course of liver injury that is typical for a specific disease or injury from a specific medication.
Clinical signs
- Findings on physical examination such as rash, fever, enlarged or tender liver and jaundice.
Clinical symptoms
- Patient complaints such as fatigue, nausea, poor appetite, dark urine or yellow discoloration of the skin (jaundice).
Coagulopathy
- Abnormal bleeding tendency which can be caused by lack of clotting factors that are made by the liver.
Collagen
- The major protein found in scars and that is increased in cirrhosis of the liver.
Corticosteroid
- A hormone that is used as a medication to treat inflammation; examples include prednisone, cortisone, and dexamethasone.
Cyclophosphamide
- An anticancer medication.
Cytosine arabinoside
- An anticancer medication.
Cytotoxic agents
- Medications or chemicals that cause damage to cells.
- Dark or tea-colored urine is a symptom of liver disease caused by elevations in serum bilirubin and secretion of bilirubin in the urine.
Defibrotide
- A medication used to treat sinusoidal obstruction syndrome.
Diclofenac
- An oral nonsteroid antiinflammatory agent (NSAID).
Dicloxacillin
- A semisynthetic penicillin antibiotic.
Didanosine (DDI)
- An antiviral drug used to treat AIDS and HIV infection.
Dietary Supplements
- Vitamins, minerals, herbal medications and medicinal foods that are not officially used as therapy of a specific disease or condition.
Disulfiram
- A drug used to treat alcohol dependence (also called Antabuse).
Ductopenia
- Finding on liver histology of a decrease or lack of small bile ducts in the liver.
Ductules
- The smallest bile ducts that can be seen on liver histology.
- Tissue swelling of the feet, ankles or other parts of the body caused by abnormal accumulation of fluid which can be the result of heart, kidney or liver failure.
Eosinophilia
- Increased eosinophils in the blood (the white blood cells that are active in allergic reactions).
Elastography
- A noninvasive X-ray method of measuring stiffness of the liver, which is increased with advancing fibrosis and cirrhosis.
Enalopril
- A "calcium channel blocker" blood pressure medication.
Encephalopathy
- Mental confusion and altered level of consciousness that can occur in liver failure.
Endothelial cell
- The cells in the liver that line the blood channels (sinusoids).
Ephedra
- An herbal medication used as a stimulant and weight loss agent, which has been banned from use because of cardiac (heart) complications.
Erlotinib
- An anticancer medication.
Esophagus
- The muscular swallowing tube that runs from the mouth to the stomach.
- The breakdown product of triglycerides and fat that are taken up by the liver and used as a source of energy or to make triglycerides.
Fenofibrate
- A lipid lowering medication.
Fialuridine
- An antiviral agent for hepatitis B that was found to cause severe liver injury.
Fibrosis
- The presence of scarring in the liver, usually shown by liver biopsy histology.
Flutamide
- An antiandrogen used to treat prostate cancer.
Focal nodular hyperplasia
- A benign tumor of the liver.
Gamma glutamyl transpeptidase (GGT)
- An enzyme found in the blood that is elevated with liver injury, particularly cholestatic. This is also commonly elevated in recent alcohol consumption.
Gemcitabine
- An anticancer medication.
Glutathione
- A substance made in the liver that binds to and helps remove drugs and toxins.
Glycogen
- The principal storage form of glucose (sugar) in the liver.
Granulomatous hepatitis
- Liver injury in which granulomas (small collections of inflammatory cells) are found in the liver biopsy.
Graves' disease
- A disease of the thyroid (hyperthyroidism)
- A general anesthetic agent that was found to cause severe liver injury and is now rarely used.
Hepatic encephalopathy
- Confusion, mental dullness, drowsiness and even coma caused by liver failure.
Hepatitis A
- Infectious liver disease, spread primarily through the fecal-oral route, caused by the hepatitis A virus; now preventable by vaccine. Most people recover and the infection does not become chronic.
Hepatitis B
- Infectious liver disease caused by the hepatitis B virus, spread primarily through sexual contact or through perinatal (vertical) transmission; now preventable by vaccine. Approximately 5% of acute hepatitis B cases become chronic.
Hepatitis C
- Infectious liver disease caused by the hepatitis C virus for which there is no vaccine and which commonly becomes chronic; now the most common cause of cirrhosis in the United States.
Hepatitis D
- Rare but severe liver disease caused by the hepatitis D virus, which only affects persons who are also infected with hepatitis B.
Hepatitis E
- Infectious form of viral hepatitis that is rare in the United States but common in the developing world; may also be spread by contact with pigs or wild boar.
Hepatocellular injury
- Liver injury in which liver cell damage and inflammation are prominent.
Hepatocyte
- The major cells in the liver, responsible for its function.
Hepatotoxicity
- Toxin injury to the liver due to a medication, chemical, herbal or dietary supplement; another term for drug induced liver injury.
Hemangioma
- A benign tumor of the liver.
Hematopoietic cell transplantation
- Transplantation of blood elements such as bone marrow or stem cells.
Hepatic venous pressure gradient
- A diagnostic measurement of the pressure inside the veins of the liver that is increased in cirrhosis.
Hepatomegaly
- Enlargement of the liver.
Hyperammonemia
- High levels of ammonia in the blood which can occur in liver failure.
Hyperlipidemia
- Abnormally high levels of lipids (cholesterol, triglycerides) in the blood.
- Liver injury with prominent features of allergy or hypersensitivity. Typically, this includes fever, rash, and/or hives.
Immunoglobulin
- A class of blood proteins that include antibodies.
Interlobular bile ducts
- The larger bile ducts in the liver that allow the flow of bile from intralobular bile ducts to the larger bile ducts that, ultimately, direct bile to the gallbladder and intestine.
Intralobular bile ducts
- The small conduits (ducts) in the liver than allow the flow of bile from liver cells to the larger, interlobular bile ducts.
Ischemic hepatitis
- Severe hypotension (shock), lack of oxygen (anoxia), or sudden heart failure that leads to decreased blood flow to the liver; usually resolves quickly if the sudden insult is corrected.
Isoniazid
- An antituberculosis medication.
Itching
- Irritating skin sensation that provokes scratching, a symptom of liver disease, particularly cholestatic (also known as "pruritus").
- A home brewed tea from Jamaica.
Jaundice of sepsis
- Jaundice occurring in the setting of severe bacterial infections (sepsis) that resolves if the infection in treated; liver biopsy shows prominent cholestasis.
Jaundice
- Yellowish tinge to the skin or whites of the eyes caused by elevation in bilirubin in the blood; also called "icterus".
- An oral antifungal medication.
- High levels of lactic acid in the blood, usually caused by failure of mitochondrial function in the liver.
Large bile ducts
- The bile ducts in the liver (right and left hepatic duct) and outside of the liver (common bile duct) allow the flow of bile to the gallbladder and intestine.
Latency
- The duration between ingestion, or exposure, to a drug, toxin, or infectious agent and the onset of disease.
Liver histology
- Findings on microscopic assessment of a liver biopsy.
Liver inflammation
- Findings of white blood cells (inflammatory cells) in the liver on microscopic assessment of a liver biopsy.
Liver test abnormalities
- Blood tests results that indicate liver injury such ALT, AST, alkaline phosphatase, bilirubin, albumin and prothrombin time (or INR).
Liver transplantation
- Replacement of a person's liver with that of another person, used to treat end stage liver disease, acute liver failure, liver cancer and rare genetic disorders.
- Abnormal large droplets of fat found in liver cells; typically, the nucleus is pushed to one side of the cell by fat droplets.
Methotrexate
- An oral anticancer and immunosuppressive medication.
Methyldopa
- A blood pressure medication.
Microvesicular fat
- Abnormal numbers of small droplets of fat in liver cells; typically, the nucleus remains in the center of the cell.
Minocycline
- A tetracycline-like antibiotic often used for acne.
Mitochondria
- A component found in all living cells that is responsible for producing energy and is essential for health.
Mixed injury
- Liver injury with features of both hepatocellular and cholestatic injury.
Mononucleosis
- Acute illness caused by the Epstein Barr virus that can cause liver disease that resembles acute viral hepatitis.
Mononucleosis
- Acute illness caused by the Epstein Barr virus that can cause liver disease that resembles acute viral hepatitis.
M & V Scale
- A causality assessment method similar to RUCAM developed by Drs. Maria and Victorino.
Myeloablation
- Deliberate destruction of the bone marrow by chemotherapy, done in preparation of bone marrow transplantation.
- A causality assessment method for assessing all forms of drug induced adverse events.
Niacin
- Vitamin B6, often used to treat high blood cholesterol.
Nitrofurantoin
- An antibiotic used to treat urinary tract infections.
Nodular regenerative hyperplasia
- Unusual transformation of the normal liver structure into nodules. Typically, there is little or no scar tissue, differentiating this from cirrhosis.
Nonparenchymal
- A liver histology term referring to those parts of the liver other than the major hepatocytes (liver cells) including the endothelial cells, macrophages, veins, arteries and bile ducts.
Nonsteroidal antiinflammatory drugs (NSAIDs)
- A large and commonly used class of medications that inhibit pain and inflammation but are not corticosteroids; this class includes ibuprofen, naproxen, diclofenac and many other agents.
- A liver histology term referring to the part of the liver with hepatocytes (liver cells) as opposed to the areas with supporting cells, veins, arteries and bile ducts.
Phenytoin
- A commonly used antiepilepsy medication (Dilantin™).
Portal inflammation
- Findings of inflammatory cells on liver biopsy in areas around the veins, arteries and bile ducts entering the liver.
Primary biliary cirrhosis
- A chronic liver disease marked by gradual autoimmune loss of bile ducts leading ultimately to cirrhosis.
Primary sclerosing cholangitis
- A chronic autoimmune disease marked by damage and loss of the large bile ducts that can lead to liver damage and cirrhosis.
Prodromal
- In acute liver disease, the period of symptoms, frequently vague, immediately before appearance of jaundice.
Prothrombin time
- A measure of clotting ability that becomes abnormal (prolonged) with liver failure.
Pruritus
- Itchiness of the skin, a symptom of liver disease, particularly cholestatic.
- Resembling radiation effects.
Rechallenge
- Reexposure, deliberate or accidental, of a patient to a medication that was believed to have caused an adverse side effect, such as drug induced liver injury.
RUCAM
- The Roussel Uclaf Causality Assessment Method for evaluating the likelihood that a medication has caused drug induced liver injury.
R value
- The ratio of alanine aminotransferase (ALT) to alkaline phosphatase (Alk P) values, both expressed as multiples of the upper limit of normal. An R value of >5.0 is used to define hepatocellular injury, R <2.0 as cholestatic injury, and R between 2.0 to 5.0 as mixed hepatocellular-cholestatic injury.
Sinusoidal-obstruction syndrome (SOS)
- Liver histology findings indicating a blockage of blood flow out of the liver.
- An oral antiviral medication used for HIV infection (d4T).
Stevens Johnson syndrome
- Sudden onset of fever and severe body rash often due to an allergic reaction to a medication.
Sulfonamides
- A class of antibiotics.
Sulfonylureas
- A class of antidiabetes medications which includes glyburide.
Sulindac
- An oral nonsteroid antiinflammatory agent (NSAID).
- An oral antibiotic in restricted use.
Tetracycline
- An oral antibiotic.
Triglycerides
- One of the major forms of fat that is produced in the liver and found in the blood.
- An oral antiepilepsy medication.
Vanishing bile duct syndrome (VBDS)
- A chronic form of liver disease in which there is a gradual loss of small bile ducts in the liver (ductopenia).
Veno-occlusive disease (VOD)
- Another term for "sinusoidal-obstruction syndrome" or liver histology findings indicating a blockage of blood flow out of the liver.
Viral hepatitis
- Liver disease caused by one of 5 hepatitis viruses (A, B, C, D or E).
- An inherited disease marked by accumulation of copper in the liver, brain and other tissues that can cause cirrhosis and be fatal if not detected early and treated.
- An oral antiviral medication used for HIV infection (AZT).