National Toxicology Program

CASRN: 106-94-5

Formula: C3-H7-Br

Synonyms/Common Names:

• PROPYL BROMIDE
• N-PROPYL BROMIDE

Known Uses:

Laboratory reagent; replacement chemical for chlorinated solvents; metal cleaning and degreasing, adhesives.

Nomination Background

Short-Term Toxicity

• 2-WEEK (Inhalation)  (C20011)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 125, 250, 500, 1000, OR 2000 PPM; 5/SEX/SPECIES/DOSE.
• 13-WEEK (Inhalation)  (C20011)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 62.5, 125, 250, 500, OR 1000 PPM; 20/SEX/DOSE M: 0, 62.5, 125, 250, OR 500 PPM; 10/SEX/DOSE.

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C20011)  Completed 
  • TR-564 (NIH Number: 10-5906; NTIS Number: PB2011-114187)  (Peer Review Approval 11/19/2009A )
    Toxicology and Carcinogenesis Studies of 1-Bromopropane (CAS No. 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Clear Evidence 
  • Male Mice No Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0, 125, 250, OR 500 PPM; M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES/DOSE.

Special Studies

• Absorption Disposition Metabolism Elimination (Inhalation; Intravenous; Topical Application)  (S0829)  Completed 
  • Citation: STUDIES OF CHEMICAL DISPOSITION IN MAMMALS. FINAL STUDY REPORT. STUDY OF 1-BROMOPROPANE. 01/30/01-06/24/05. INCLUDING ALL APPENDICES. JULY 18, 2005. RTI
  • Male and Female Rats: F344/N; Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male and Female Mice: B6C3F1
  • Dose: IV: 5, 20, 100 mg/kg. Dermal: 100 mg/kg. INHAL: 70, 240, 800, 2700 PPM..

Genetic Toxicology

• Micronucleus  (A52458)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A39304)  Completed 
  •  Negative 
• Salmonella  (A96196)  Completed 
  •  Negative 
• Salmonella  (G00017)  Completed 
  •  Negative