1-Bromopropane
CASRN: 106-94-5
Formula: C3-H7-Br
Synonyms/Common Names:
- PROPYL BROMIDE
- N-PROPYL BROMIDE
Known Uses:
Laboratory reagent; replacement chemical for chlorinated solvents; metal cleaning and degreasing, adhesives.
Nomination Background
Short-Term Toxicity
- 2-WEEK (Inhalation)
(C20011)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 125, 250, 500, 1000, OR 2000 PPM; 5/SEX/SPECIES/DOSE.
- 13-WEEK (Inhalation)
(C20011)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 62.5, 125, 250, 500, OR 1000 PPM; 20/SEX/DOSE M: 0, 62.5, 125, 250, OR 500 PPM; 10/SEX/DOSE.
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C20011)
Completed
- TR-564 (NIH Number: 10-5906; NTIS Number: PB2011-114187)
(Peer Review Approval 11/19/2009A )
Toxicology and Carcinogenesis Studies of 1-Bromopropane (CAS No. 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats Clear Evidence
- Male Mice No Evidence
- Female Mice Clear Evidence
- Dose: R: 0, 125, 250, OR 500 PPM; M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES/DOSE.
- TR-564 (NIH Number: 10-5906; NTIS Number: PB2011-114187)
(Peer Review Approval 11/19/2009A )
Special Studies
- Absorption Disposition Metabolism Elimination (Inhalation; Intravenous; Topical Application)
(S0829)
Completed
- Citation: STUDIES OF CHEMICAL DISPOSITION IN MAMMALS. FINAL STUDY REPORT. STUDY OF 1-BROMOPROPANE. 01/30/01-06/24/05. INCLUDING ALL APPENDICES. JULY 18, 2005. RTI
- Male and Female Rats: F344/N; Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male and Female Mice: B6C3F1
- Dose: IV: 5, 20, 100 mg/kg. Dermal: 100 mg/kg. INHAL: 70, 240, 800, 2700 PPM..
Genetic Toxicology
- Micronucleus
(A52458)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(A39304)
Completed
- Negative
- Salmonella
(A96196)
Completed
- Negative
- Salmonella
(G00017)
Completed
- Negative
Web page last updated on January 15, 2013