National Toxicology Program

CASRN: 150-38-9

Formula: C10-H16-N2-O8.3Na

Synonyms/Common Names:

• EDTA
• N,N'-1,2-ETHANEDIYLBIS(N-CARBOXYMETHYL)GLYCINE TRISODIUM SALT (9CI)
• TRISODIUM ETHYLENEDIAMINE TETRACETATE TRIHYDRATE

Known Uses:

Chelating agent; antioxidant in food; used in cosmetics, drugs, rubber, textiles

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03974)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03974)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,4640,21600 PPM/10 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03974)  Report Complete 
  • TR-011 (NIH Number: 77-811; NTIS Number: PB270938)  (Peer Review Approval 07/25/1977A )
    Bioassay of Trisodium Ethylenediaminetetraacetate Trihydrate (EDTA) for Possible Carcinogenicity (CASRN 150-38-9)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,3750,7500 PPM/50 PER GROUP.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (215387)  Completed 
  • Sister Chromatid Exchange Negative 
  • Chromosome Aberation Negative 
• Mouse Lymphoma  (127205)  Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  • Mice
  •  Negative 
• Salmonella (NCI)  (N-9245)  Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella
  • Salmonella-NCI  Negative 
• Salmonella  (255190)  Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative