Viral “Molecular Scissor” is Next COVID-19 Drug Target
Submitted by kperry on Tue, 10/27/2020 - 15:24Structural work on SARS-CoV-2 papain-like protease, SARS-CoV-2-PLpro, required for processing viral polyproteins to generate a functional replicase complex and enable viral spread has been featured as a highlight on the APS website.
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein.
SARS-CoV-2 disguises its own genetic material to facilitate infection
Submitted by kperry on Sun, 07/26/2020 - 08:39Work on SARS-CoV-2 RNA capping by the lab of Yogesh Gupta using NE-CAT and previously published at BioRxiv has now been published at Nature Communications, featured on the Science Board website and is also a highlight on the APS website
3-D Structure of SARS-CoV-2 Explains High Infectivity vs. Other Coronaviruses
Submitted by kperry on Wed, 06/10/2020 - 15:18Structural Basis of RNA Cap Modification by SARS-CoV-2 Coronavirus
Submitted by kperry on Sat, 05/02/2020 - 17:15Army-developed Vaccine Induces Potent Zika and Dengue Cross-neutralizing Antibodies
Submitted by kperry on Wed, 04/08/2020 - 08:42Structural basis of receptor recognition by SARS-CoV-2.
A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein
Submitted by kperry on Tue, 03/24/2020 - 12:51SARS-CoV-2 is a zoonotic virus that has caused a pandemic of severe respiratory disease—COVID-19— within several months of its initial identification. Comparable to the first SARS-CoV, this novel coronavirus’s surface Spike (S) glycoprotein mediates cell entry via the human ACE-2 receptor, and, thus, is the principal target for the development of vaccines and immunotherapeutics.
Illinois Stay-At-Home Order
Submitted by kperry on Sat, 03/21/2020 - 00:00Per the Illinois Stay-At-Home Order, NE-CAT has only has available beamtime for COVID-19 related research. On-site access is not available and all data collection must be conducted remotely.
TO: All Employees
Rapid Access Beamtime for COVID-19 Research
Submitted by kperry on Wed, 02/19/2020 - 00:00On February 18, 2020, in support of the COVID-19 outbreak, NE-CAT provided rapid access beamtime to researchers from the Walter Reed Army Institute of Research working on the the SARS-CoV-2 S glycoprotein receptor-binding-domain. The novel coronavirus's surface Spike (S) glycoprotein mediates cell entry via the human ACE-2 receptor, and is the principal target for the development of vaccines and immunotherapeutics.
Rapid Access Beamtime is available for all research projects related to COVID-19.
EIGER2 X Installed on 24-ID-C
Submitted by Updates on Tue, 01/07/2020 - 14:02The APS is currently in shutdown for maintenance until the end of January and NE-CAT has used this opportunity to move the EIGER2 from the dry lab and onto the C beamline. The new detector still needs its protective cover, colloquially called the guillotine, manufactured by Ed Lynch before commissioning proceeds.
EIGER2 X has arrived!
Submitted by Updates on Tue, 12/10/2019 - 12:28The first EIGER2 X 16M in the United States has arrived safely at NE-CAT. This is the largest detector in the EIGER2 line with a 75 x 75 μm pixel and 18,093,576 pixels. It will provide rapid and accurate photon counting. Pascal Hofer and Zachary Brown from Dectris are on-site for initial testing of the detector in the dry lab. We can report that all 32 modules are alive.