Stars in Nutrition & Cancer

Novel Omega-3 Mediators & Mechanisms in the Resolution of Inflammation: What can they tell us about Preventative and Therapeutic Approaches?

Star Speaker

Charles N. Serhan, PhD
Director, Center for Experimental Therapeutics and Reperfusion Injury
Brigham and Women's Hospital
The Simon Gelman Professor of Anesthesia (Biochemistry and Molecular Pharmacology)
Professor of Oral Medicine, Infection and Immunity
Harvard University

Meeting Date

March 13, 2012

Meeting Time

2:00 pm – 3:00 pm
2:00 pm Opening Remarks
2:15 pm Lecture and Discussion

View video

Meeting Location

Lipsett Amphitheater
Building 10
NIH Main Campus
Bethesda, MD

Objectives

Define the functional differences between anti-inflammation versus pro-resolution and the cell types involved;
Define the anti-inflammatory and pro-resolving lipid mediators;
Review the biosynthesis and omega-3 precursors (EPA and DHA) of the resolvins, protectins and maresins (E-series vs. D-series resolvins) and their actions;
Define the resolution indices: what enhances resolution and the drugs that are resolution toxic; and
What are the key cellular targets of the resolvins and mechanism(s) (e.g. receptors, miR, etc.) that define resolving autacoids in animal inflammatory diseases.

Point of Contact

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Event is pre-approved by the CDR for 1 credit for Registered Dietitians.