Demystifying Medicine
Course Materials for 2009
FINAL EXAMINATION
- January 13, 2009, "Bacterial sepsis: A new epidemic and an old receptor"
- Tara Palmore presentation
- Gilbert Ashwell presentation
- John Hanover presentation
- Readings:
- van 't Veer C. and van der Poll T. (2008) Keeping blood clots at bay in sepsis. Nature Medicine 14(6):606-608 (PDF, 1.1 MB)
- Grewal PK, Uchiyama S., Ditto D., Varki N., Le D.T., Nizet V. and Marth J.D. (2008) The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nature Medicine 14(6):648-655 (PDF, 580 KB)
- Angus, D.C., Linde-Zwirble, W.T., Lidicker, J. et al. Crit Care Med 2001; 29(7): 1303-10.
- Blanco, J., Muriel-Bombin, A., Sagredo, V. et al. Crit Care 2008; 12(16): R158 [Epub].
- Dombrovskiy, V.Y., Martin, A.A., Sunderram, J. Paz, H.L. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007; 35(5): 1244-50.
- Emonts, M., Hazelzet, J.A., de Groot, R., Hermans, P.W. Host genetic determinants of Neisseria meningitides infections. Lancet Infect Dis 2003; 3(9): 565-77.
- Hofhuis, J.G., Spronk, P.E., van Stel, H.F. et al. The impact of critical illness on perceived health-related quality of life during ICU treatment, hospital stay, and after hospital discharge: a long-term follow-up study. Chest 2008; 133(2): 377-85.
- Kumar, A., Roberts, D., Wood, K.E. et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34(6): 1589-96.
- Natanson, C., Danner, R.l., Reilly, J.M. et al. Antibiotics verus cardiovascular support in a canine model of human septic shock. Am. J. Physiol 1990; 259(5 pt 2): H1440-7.
- Russell, J.A. Management of Sepsis. New Engl J Med 2006; 355(16): 1699-713.
- Schlievert, P.M. Nat Med 2000; 6(4): 378-9.
- Wenzel, R.P. Treating Sepsis. New Engl J Med 2002; 347(13): 966-7.
- Federal Holiday - Session to be Rescheduled: January 20, 2009, "Viral hepatitis: A global problem and the role of interferon"
- Ghany presentation
-
Zoon presentation
- Readings:
- Raymond T. Chung, Michael Gale Jr, Stephen J. Polyak, Stanley M. Lemon, T. Jake Liang, Jay H. Hoofnagle. Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop, Hepatology, 47:306-320, 2008.
- Satoshi Uematsu, Shizuo Akira, Toll-like Receptors and Type I Interferons, Journal of Biological Chemistry, 2007 Special Minireview Compendium, 282:1531915323, 2007.
- Kathie-Anne Walters, Michael Katze, Using high-throughput genomics to study hepatitis C: What determines the outcome of infection?. Antiviral Research 81:198-208, 2009.
- Joseph Bekisz, Hana Schmeisser, Jessica Hernandez, Neil D. Goldman, Kathryn C. Zoon, Human Interferons Alpha, Beta and Omega, Growth Factors, 22:243-251, 2004.
- January 27, 2009, "HIV: The epidemic persists globally and locally"
- February 3, 2009, "Intestinal bacterial infections and the food chain"
-
Arias introduction
- Savarino presentation
- Robbins presentation
- Readings:
- January 28, 2009 NY TIMES - Salmonella Was Found at Peanut Plant Before. The Georgia food plant that federal investigators say knowingly shipped contaminated peanut butter also had mold growing on its ceiling and walls, and it has foot-long gaps in its roof, according to results of a federal inspection. - by Gardiner Harris
- Mead PS, Slutsker L, Dietz V, McCaig LF, Bresee JS, Shapiro C, Griffin PM, Tauxe RV. Food-Related Illness and Death in the United States. Emerg Infect Dis 1999;5 (5):607-625.
- Scallan E. Activities, Achievements, and Lessons Learned during the First 10 Years of the Foodborne Diseases Active Surveillance Network: 1996–2005. Clin Infect Dis 2007: 44:718–25.
- DuPont HL. The growing threat of foodborne bacterial enteropathogens of animal origin. Clin Infect Dis. 2007;45(10):1353-61 (Review).
- Outbreak of Salmonella Serotype Saintpaul Infections Associated with Multiple Raw Produce Items - United States, 2008. MMWR 2008;57(34):929-934.
- Petri WA Jr, Miller M, Binder HJ, Levine MM, Dillingham R, Guerrant RL. Enteric infections, diarrhea, and their impact on function and development. J Clin Invest. 2008 Apr;118(4):1277-90 (Review).
- Frenzen PD. Economic cost of Guillain-Barre´ syndrome in the United States. Neurol 2008;71:21–27.
- February 10, 2009, "Melanoma and the sun"
- Hornyak presentation
- Tucker presentation
-
JYang presentation
- Readings:
- Tucker MA. Is Sunlight Important to Melanoma Causation? Cancer Epidemiol Biomarkers Prev 2008; 17(3). March 2008. (PDF, 40KB)
- Tucker MA & Co-Workers. Feature associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J. Med. Genet. 2007; 44; 99-106. (PDF, 236KB)
- Fears TR, Guerry D, Pfeiffer RM, Sagebiel RW, Elder DE, Halpern A, Holly EA, Gartge P, Tucker MA. Identifying Individuals at High Risk of Melanoma: A Practical Predictor of Absolute Risk. Journal of Clinical Oncology. 2006 24(22); 1-8. (PDF, 268KB)
- Fears TR, Bird CC, Guerry D, Sagebiel RW, Gail MH, Elder DE, Halpern A, Holly EA, Hartge P, Tucker MA. Average Midrange Ultraviolet Radiation Flux and Time Outdoors Predict Melanoma Risk. Cancer Research 62, 3992-3996, July 15, 2002. (PDF, 68KB)
- van der Bruggen P., Traversari C., Chomez P., Lurquin C., De Plaen E., van den Eynde B., Knuth A., Boon T. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643-7, 1991. 2.
- Smith FO, Downey SG, Klapper JA, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Restifo NP, Levy CL, White DE, Steinberg SM, Rosenberg SA. Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines. Clin Cancer Res, 14:5610-8, 2008. 3.
- Dudley, M.E., Wunderlich, J.R., Robbins, P.F., Yang, J.C., Hwu, P., Schwartzentruber, D.J., Topalian, S.L., Sherry, R., Restifo, N.P., Hubicki, A.M., Robinson, M.R., Raffeld, M., Duray, P., Seipp, C.A., Rogers-Freezer, L., Morton, K.E., Mavroukakis, S.A., White, D.E., and Rosenberg, S.A.: Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298:850-854, 2002. 4.
- Rosenberg, S.A., Yang, J.C., Restifo, N.P. Cancer Immunotherapy: Moving beyond current vaccines. Nature Medicine 10:909-915, 2004. 5.
- Dudley ME, Wunderlich JR, Yang JC, Sherry RM, Topalian SL, Restifo NP, Royal RE, Kammula U, White DE, Mavroukakis SA, Rogers LJ, Gracia GJ, Jones SA, Mangiameli DP, Pelletier MM, Gea-Banacloche J, Robinson MR, Berman DM, Filie AC, Abati A, Rosenberg SA. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol. Apr 1;23(10):2346-57, 2005. 6.
- Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM, Royal RE, Topalian SL, Kammula US, Restifo NP, Zheng Z, Nahvi A, de Vries CR, Rogers-Freezer LJ, Mavroukakis SA, Rosenberg SA. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. Oct; 314(5796):126-9, 2006.
- Gray-Schoper VC, Cheong SC, Chong H, Chow J, Moss T, Abdel-Malek ZA, Marals R, Wynford-Thomas D, Bennett DC, Cellular senscence in naevi and immortalisation in melanoma: a role for p16? British Journal of Cancer (2006) 95, 496-505. (PDF, 428KB)
- Michaloglou C, Vredeveld LCW, Soengas MS, Denoyelle C, Kuilman T, van der Horst CMAM, Majoor DM, Shay JW, Mooi WJ, Pepper DS. BRAF^E600- associated senescence-like cell cycle arrest of human naevi. Nature 436, 4-August-2005, 720-724.
- February 17, 2009, "Spinal cord injury and stem cells"
- February 24, 2009, "Diabetes, Type 2: The epidemic continues"
- March 3, 2009, "Arteriosclerotic cardiovascular disease: Number one killer and the Framingham experience"
- March 10, 2009, "Fibrous dysplasia of bone and stem cells"
- March 17, 2009, "Blindness"
- March 24, 2009, "Hepatocellular cancer: A global epidemic"
- March 31, 2009, "Fragile X: Most common inheritable retardation defect"
- April 7, 2009, "Drug resistance and cancer"
- April 14, 2009, "Aging, progeria, and heart disease"
-
Introne presentation
-
Mistelli presentation
- Readings:
- Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith AC, Perry MB, Brewer CC, Zalewski C, Kim HJ, Solomon B, Brooks BP, Gerber LH, Turner ML, Domingo DL, Hart TC, Graf J, Reynolds JC, Gropman A, Yanovski JA, Gerhard-Herman M, Collins FS, Nabel EG, Cannon RO 3rd, Gahl WA, Introne WJ. Phenotype and course of Hutchinson-Gilford progeria syndrome. N Engl J Med. 2008 Feb 7;358(6):592-604.
- Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Tavarez UL, Conneely KN, Qu X, San H, Ganesh SK, Chen X, Avallone H, Kolodgie FD, Virmani R, Nabel EG, Collins FS. A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15902-7. Epub 2008 Oct 6.
- Varga R, Eriksson M, Erdos MR, Olive M, Harten I, Kolodgie F, Capell BC, Cheng J, Faddah D, Perkins S, Avallone H, San H, Qu X, Ganesh S, Gordon LB, Virmani R, Wight TN, Nabel EG, Collins FS. Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3250-5. Epub 2006 Feb 21.
- Stehbens WE, Wakefield SJ, Gilbert-Barness E, Olson RE, Ackerman J. Histological and ultrastructural features of atherosclerosis in progeria. Cardiovasc Pathol. 1999 Jan-Feb;8(1):29-39.
- NIH Fact Sheet - Progeria
- April 21, 2009, "Excema and the skin microbiome"
- Segre presentation
- Komarow presentation
- Readings:
- April 28, 2009, "Human papilloma virus and cancer: Prevention by vaccination"
- May 5, 2009, "Multiple myeloma: Diagnosis and treatment in the genomic era"
-
Arias introduction
- Schechter presentation
-
Shaffer presentation
- Readings:
- Shaffer AL, Emre NC, Romesser PB, Staudt LM (2009)
IRF4: Immunity. Malignancy! Therapy? Clin Cancer Res. 2009 Apr 21. [Epub ahead of print]
- Arthur L. Shaffer, N.C. Tolga Emre, Laurence Lamy, Vu N. Ngo, George Wright, Wenming Xiao, John Powell, Sandeep Dave, Xin Yu, Hong Zhao, Yuxin Zeng, Bangzheng Chen, Joshua Epstein and Louis M. Staudt (2008) IRF4 Addiction in Multiple Myeloma. Nature 454:226-231.
- A loss-of-function RNA interference screen for molecular targets in cancer.
Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G, Lam LT, Dave S, Yang L, Powell J, Staudt LM. Nature. 2006 May 4;441(7089):106-10. Epub 2006 Mar 29.
- Multiple Myeloma, RA Kyle and SV Rajkumar
- Multiple Myeloma Reserach Foundation - Intro to Myeloma
- May 12, 2009, "Finale: Career opportunities in biomedical science for PhDs"
- May 19, 2009, "Viral hepatitis: A global problem and the role of interferon"
-
Ghany presentation
-
Zoon presentation
FINAL EXAMINATION
This web page was last modified on May 22, 2009. For questions about the course, please contact ariasi@mail.nih.gov.