In this 2-year trial involving patients with Parkinson’s disease and early motor complications, subthalamic stimulation plus medical therapy resulted in better quality of life and motor function than medical therapy alone.
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Inhibition of mitogen-activated protein kinase resulted in an increase in expression of the sodium–iodide symporter in 12 of 20 patients, 8 of whom had sufficient uptake to warrant treatment with radioiodine. Five patients had a response, and 3 had stable disease.
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(DOI: 10.1056/NEJMp1214141)
(DOI: 10.1056/NEJMoa1212793)