The clinical oncology area of interest involves clinical research designed to evaluate cancer treatment. This category includes all Phase 0, I, II and III clinical trials using drugs and biological agents, including gene therapy. Preclinical studies that address specific issues related to the design of a clinical trial may be included in this category, but should not be the objective of the grant application.
Studies conducted with the intent of selecting patients for therapy and predicting response to specific therapies:
Clinical studies utilizing gene therapy, gene silencing and gene marking for tracking disease recurrence
Chemotherapy alone or in combination with radiotherapy or surgery
Clinical studies involving:
Studies conducted with the intent of selecting patients for therapy and predicting response to the specific therapies:
Clinical studies to reduce the toxicity of cytotoxic therapies by the use of agents such as:
Clinical studies utilizing gene therapy and gene marking for tracking disease recurrence
All types of stem cell and bone marrow transplantation in cancer patients
Clinical studies using biological response modifiers or biological approaches to cancer treatment such as vaccines, immunotherapy, cellular therapy, antisense therapy and the use of liposomes
Clinical studies using agents directed at subcellular target sites including cell cycle targets, oncogenes and suppressor genes
Clinical investigation, including experimental design, computer programming and biostatistics, radiological, histopathological and immunological support
Supportive care programs emphasizing preclinical and quality of life through supportive management of cancer patients undergoing anti-neoplastic treatment(s)
Ethical issues in human subject research as it relates to clinical trial participation, such as informed consent, data and safety monitoring, enrollment/accrual of participants, inclusion of children, and research oversight
Interventional studies in which surgery is the dominant feature to prevent, diagnose, stage, or treat cancer; all surgical specialties, except neurosurgery and eye surgery, are included
Novel infusion/perfusion devices for use with biological or chemotherapeutic agents
Development and improvement of instruments for detection or diagnosis of tumors where surgery/biopsies is the dominant feature process
Novel or improved surgical techniques aimed to significantly increase or enhance outcomes in cancer treatment