Citation:

Villeneuve, D. Application of computational toxicology to prospective and diagnostic ecological risk assessment. Presented at National Center for Computational Toxicology, Communities of Practice Seminar Series, January 24, 2013.

Description:

When the National Research Council published their Vision and Strategy for Toxicity Testing in the 21st Century, the sole focus was human health-related toxicity testing. However, ecotoxicity testing faces many of the same challenges and limitations relative to its traditional reliance on a whole animal testing paradigm. This presentation will provide perspectives on how the tools and approaches of computational toxicology can be applied to ecological risk assessment questions. Specifically, it will describe how adverse outcome pathway knowledge can be applied to facilitate use of high throughput molecular screening data (e.g., Toxcast data) for ecological hazard assessment and prioritization of ecological toxicity testing. Additionally, it will discuss an envisioned role for high throughput screening and other computational toxicology approaches in environmental monitoring and surveillance.

Purpose/Objective:

not applicable

URLs/Downloads:

ABSTRACT.PDF   (PDF,NA pp, 70.952 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)

Record Last Revised: 02/12/2013

Record Created: 02/12/2013

Record Released: 02/12/2013

OMB Category: Other

Record ID: 251880

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

MID-CONTINENT ECOLOGY DIVISION

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