Metabolism, Diet, and Disease Conference

Well, it’s  Back to the Better-Late-Than-Never…

There’s an interesting conference starting Tuesday the 29th in Washington – today –and I should have written about it months ago. It’s the Metabolism, Diet and Disease conference being held at the Georgetown University Conference Center. The editors of BioMed Central, a British open-access science publishing company, are the organizers. They contacted me in October 2010 to tell me they had read the British version of Good Calories, Bad Calories The Diet Delusion – and found it compelling. They were particularly struck by the notion that there are many disciplines involved in the science of obesity, diabetes and their associated chronic diseases, but they don’t read the same journals and they don’t tend to interact in conferences. So their idea was to put together a conference that would solve this problem. Between us, we recruited a first-rate executive board – including the two Nobel Laureates, Michael Brown and Joseph Goldstein – and put together a conference that, as I see it, includes most of the major issues revolving around and feeding into insulin resistance and metabolic syndrome.

The original idea – if you’ll pardon the cliché – is that insulin resistance and metabolic syndrome are the elephant, and we would get all these people in one room, who were studying the legs, the trunks, the tail, the ears, etc., and may not have realized quite what the whole elephant itself looked like. As the recruiting of speakers started, the conference evolved and took on a life of its own. Much of the original idea still exists, but there’s a fair share of the latest esoteric research ideas, for good or for bad (sirtuins, irisin, etc.), which may or may not have anything to do with the elephant itself. But we still have some of the leading researchers in the world talking about everything from the epidemiology of insulin resistance to the pathologies that associate with it – diabetes, heart disease, cancer, aging, etc. – and the pathways and mechanisms that link them all together.

One session, which I’m chairing on Thursday morning, is called “Dietary factors in metabolic diseases,” and the speakers are all addressing the carbohydrate issue.  We have Luc Tappy, the leading fructose biochemist in the world, talking about the role of fructose in metabolic disorders, and then Jeff Volek and Eric Westman talking about the effects of carb-restricted diets, suggesting that the carbohydrates (refined grains, of course, and sugars in particular) might be the fundamental problem. It will be interesting to see how the mainstream researchers take this, as they’re used to thinking about carb-restriction as quackery and now it will be presented as potentially mainstream itself.

On Saturday, I’m in Scottsdale Arizona talking at the National Lipid Associations annual convention. This, too, should be interesting, as I’ll be presenting my Why We Get Fat lecture an hour after Robert Eckel speaks. Eckel is a former president of the American Heart Association who is on record saying that he doesn’t even think low-carb-high-fat diets should ever be tested, that it’s unethical, because they’re so dangerous. After I speak, I’ll get to hear Rob Lustig and Peter Havel talk about sugar and fructose. As I said, it should be an interesting day and an interesting week.

Speak Your Mind

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Science, Pseudoscience, Nutritional Epidemiology, and Meat

  I’m writing this post with a little more haste than is my wont. I’ve received dozens of e-mails asking me to comment on the recent news — ala the the New York Times — that meat-eating apparently causes premature death and disease. So this post is likely to contain more than my usual number of typos, egregious spelling … [Read more]

On the greatly-exaggerated demise of the insulin-hypothesis

Last week, I tweeted a New England Journal of Medicine image challenge, part of the journal’s continuing education program for physicians. I suggested that it might be a source of comfort to those who were worried about the insulin hypothesis as a viable hypothesis to explain obesity and excess fat accumulation. Although I linked to … [Read more]

Updates for 2012

  Checking in after a long absence (working too hard, and blogging too little), I have news and updates for 2012. The first order of business is a letter to the editor of the New York Times in response to Tara Parker-Pope’s “The Fat Trap” article that ran on the cover of the January 1st  NYT Magazine. I … [Read more]

Catching up on lost time – the Ancestral Health Symposium, food reward, palatability, insulin signaling and carbohydrates… Part II(e, as in “end” and “enough already”)

  In our last post, we discussed, among other things, an experiment from the 1960s that Dr. Stephan Guyenet of wholehealthsource.org has evoked to support the food reward/palatability hypothesis of obesity. This was an experiment by Sami Hashim and Ted Van Itallie published in 1965. Four subjects, two lean and two obese, consumed a formula … [Read more]