Review & comment

• 

  Managing dyskinesia in Parkinson's

  Jean-Francois Daneault, Benoit Carignan, Abbas Sadikot, Michel Panisset, Christian Duval

  Dyskinesia is a major complication in the treatment of Parkinson’s Disease; Christian Duval and colleagues propose a new approach to manage the level and type of these motor symptoms and help improve patients’ quality of life

• 

  Aspirin therapy in neuropsychiatry?

  Michael Berk, Olivia Dean, Hemmo Drexhage, John McNeil, Steven Moylan, Adrienne ONeil, Christopher Davey, Livia Sanna, Michael Maes

  Michael Berk and colleagues review the potential of aspirin as a therapeutic agent in neurological and psychiatric disorders, based on the role it may play in regulating inflammation, oxidative and nitrosative stress in the brain.

• 

  Medicine for Global Health

  Gretchen Birbeck

  Gretchen Birbeck launches our new article collection, Medicine for Global Health, with an editorial, discussing the relevance of medicine in resource-limited settings, highlighting that simple interventions may help to lessen the global burden of disease.  

• 

  Implications of FEAST analysis

  John Myburgh, Simon Finfer

  Analysis of the FEAST trial explored the mechanisms behind excess mortality in African sepsis patients given fluid boluses; John Myburgh and Simon Finfer discuss the broader relevance of this result for other populations of critically ill patients.

• 

  ME/CFS and sickness behavior

  Gerwyn Morris, George Anderson, Piotr Galecki, Michael Berk, Michael Maes

  Michael Maes and colleagues review the similarities and differences between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior, concluding that the two disorders have shared pathways, but are distinct conditions.

• 

  Implications of drug-induced changes

  Allan Sniderman, George Thanassoulis

  Allan Sniderman and George Thanassoulis comment on a meta-analysis showing reduction of testosterone by statins, but argue that range of changes rather than average changes need to be considered when measuring the effects of specific drugs.