Bio
Dr. Koulen's research approaches target the development of new treatment strategies for disease that cause degeneration or acute damage of nerve cells in the central nervous system and the eye. Dr. Koulen’s research is following two strategies: to boost the self-defense mechanisms of cells in the retina and brain and to interfere with failing defense functions of retina and brain cells.
Education
Courses
Articles
Kaja, S., Mafe, O. A., Parikh, R. A., Kandula, P., Gregg, E. V., Xin, H., Mitchell, P.,…Koulen, P. (2011). Distribution and function of polycystin-2 in mouse retinal ganglion cells. Neuroscience .
Kaja, S., Hilgenberg, J. D., Everett, E., Olitsky, S. E., Gossage, J., & Koulen, P. (2011). Effects of dilution and prolonged storage with preservative in a polyethylene container on bevacizumab (avastintm) for topical delivery as a nasal spray in anti-hereditary hemorrhagic telangiectasia and related therapies. Human Antibodies.
Burroughs, S. L., Duncan, R. S., Rayudu, P., Kandula, P., Payne, A. J., Clark, J. L., Koulen, P., & Kaja, S. (2011). Plate reader-based assays for measuring cell viability, neuroprotection and calcium in primary neuronal cultures. Journal of Neuroscience Methods.
More Articles
Kaja, S., Hilgenberg, J. D., Rybalchenko, V., Medina-Ortiz, W. E., Gregg, E. V., & Koulen, P. (2011). Polycystin-2 expression and function in adult mouse lacrimal acinar cells. Investigative Ophthalmology & Visual Sciences. 52(8), 5605-5611.
Duncan, R. S., Xin, H., Goad, D. L., Chapman, K. D., & Koulen, P. (2011). Protection of neurons in the retinal ganglion cell layer against excitotoxicity by the n-acylethanolamine, linoleoylethanolamine. Clinical Ophthalmology, 5, 543-548.
Garg, P., Duncan, R. S., Kaja, S., Zabaneth, A., Chapman, K. D., & Koulen, P. (2011). Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke. Neurosci. Lett., 492(3), 134-138. doi: 10.1016/j.neulet.2011.01.073
Burroughs, S. L., Kaja, S., & Koulen, P. (2011). Quantification of deficits in spatial visual function of mouse models for glaucoma. Invest. Ophthal. & Vis. Sci, 52(6), 3654-3659.
Sabates, F. N., Vincent, R. D., Koulen, P., Sabates, N. R., & Gallimore, G. (2011). Normative dataset identifying properties of the macula across age groups: Integration of visual function and retinal structure with microperimetry and spectral domain optical coherence tomography. Retina.
Kilaru, A., Tamura, P., Garg, P., Isaac, G., Baxter, D., Duncan, R.S., Welti, R.,…Venables, B.J. (2010). Changes in n-acylethanolamine pathway related metabolites in a rat model of cerebral ischemia/reperfusion. Journal of Glycomics & Lipidomics, doi: 10.4172/2153-0637.1000101
Kaja, S., Duncan, R.S., Longoria, S., Hilgenberg, J.D., Payne, A.J., Desai, N.M., Parikh, R.,…Koulen, P. (2011). Novel mechanism of increased ca2 release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors. Neuroscience, 23(175), 281-291. doi: 10.1016/j.neuroscience.2010.11.010
Books
Wawro, D., Zimmerman, S., Koulen, P., & Magnusson, R. (2011). Portable photonic sensor system for screening serum biomarker proteins in ovarian cancer. In Ovarian Cancer InTech - Open Access Publisher.
Koulen, P. (2003). Pharmacology of intracellular calcium channels. In H. Tien & A. Ottova (Eds.), Membrane Science and Technology Series, 7, Planar Lipid Bilayers (BLMs) and their Applications (pp. 723-734). Amsterdam, New York: Elsevier Science.
Posters/Presentations
Liu, Z., Duncan, R. S., Koulen, P., & Wagenknecht, T. (2005, October). Binding of homer protein induces conformational changes in clamp regions of skeletal muscle ryanodine receptor. Presented at 49th Annual Meeting of the Biophysical Society, Long Beach, California.
