Date of Award
Summer 8-2009
Degree Type
Internship Practicum Report
Degree Name
Master of Science
Field of Study
Forensic Genetics
Department
Graduate School of Biomedical Sciences
First Advisor
Dr. Joseph Warren
Abstract
Following a bone marrow transplant, patients are monitored closely for evidence of graft rejection or recurrence of the original disease. Bone marrow transplantation creates a donor-recipient cellular chimerism in the patient, which can be quantitively measured through short tandem repeat (STR) analysis of peripheral whole blood to determine the percent chimerism of the sample. Increasing recipient chimerism is an indication of graft rejection or relapse. Software programs designed to analyze forensic mixture samples have the potential to be useful in analyzing post-transplant mixed chimeric samples. Post-transplant samples were analyzed using three mixture deconvolution software programs. The programs were fast, accurate and consistent in determining the mixing proportions of the samples and the three programs gave concordant results.
Recommended Citation
Newman, A.
,
"Bone Marrow Engraftment Monitoring Using Mixture Deconvolution Software Designed for Forensic Casework." Fort Worth, Tx: University of North Texas Health Science Center;
(2009).
http://digitalcommons.hsc.unt.edu/theses/43