This BAA is an extramural endeavor that combines the fundamental research, educational program, or other effort needs of DTRA and other DoD interests. DTRA safeguards America and its allies from weapons of mass destruction (WMD) and provides capabilities to reduce, eliminate and counter the threat and effects from chemical, biological, radiological, nuclear, and high yield explosives. DTRA seeks to identify, adopt, and adapt emerging, existing and revolutionary sciences that may demonstrate high payoff potential to Counter-WMD (C-WMD) threats.

This announcement solicits ideas and topic-based pre-application white papers for long-term challenges that offer a significant contribution to: the current body of knowledge, to the understanding of phenomena and observable facts, to significantly advance revolutionary technology, to new concepts for technology application, or that may have impact on future C-WMD threat reduction or capabilities.

DTRA intends to create an environment where potential applicants are willing to share fundamental research results with the Government. The Government will negotiate terms and conditions to leverage the successful applicants’ advances. The Government seeks to ultimately acquire the best research and development or other CWMD-effort leading to warfighter, government or commercial products, technology and future workforce; while offering the appropriate level of protection of corporate and institutional intellectual property rights, thus encouraging participation by a broad spectrum of leading-edge science and technology developers.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=49658

Metabolomics is a rapidly growing field that has the potential to advance our understanding of human diseases and how individuals respond to therapy. It is critical to have highly trained individuals who understand the field of metabolomics and can work and communicate with clinicians and other health professionals to perform, analyze and interpret the data obtained from metabolomic studies.

This NIH Mentored Research Scientist Development Award will provide salary and research support for a sustained period of protected time (up to 4 years) for postdoctoral and clinical fellows or investigators who meet the definition of a NIH New Investigator to pursue intensive research training in the field of metabolomics under the guidance of an experienced mentor who has an established research record in metabolomics.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=204436

The purpose of this funding opportunity is to stimulate well-focused secondary analyses using existing human datasets to test innovative hypotheses concerning the epidemiology, pathophysiology, prevention or treatment of diseases/conditions relevant to the NHLBI mission. Analyzing existing datasets in novel ways provides a cost-effective method to address research questions and generate preliminary data for subsequent research proposals. 

Through a variety of mechanisms, the NHLBI supports clinical research to better clarify development, progression, prevention, and treatment of cardiovascular, pulmonary, blood, and sleep disorders. Typically, large clinical trials and epidemiologic research studies generate data with potential utility beyond the specific hypotheses and questions for which they were designed. Often these data elements are not fully utilized, especially when new research questions emerge after the project's funding has ended.

The goal of this initiative is to support early-stage exploratory studies through analyses of existing datasets.  This program will enable investigators to pursue innovative projects for which preliminary data are limited, and assist in demonstrating concept validity expected in NIH research project (R01) review.

This program is intended to generate new research hypotheses from previously collected data. The new hypotheses must be distinct from those  supported through the original research.  All data analyses must involve patient oriented or epidemiologic research designed to elucidate the etiology, incidence, prevalence, natural history, pathophysiology, prevention, or response to therapies for heart, lung, and blood and sleep disorders.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=204433

The aims of the Paul B. Beeson Career Development Awards in Aging (BCDA) program are:

• To encourage and assist the development of future leaders in the field of aging by supporting clinically trained (primarily physician) faculty members early in their careers to gain additional research training and to establish independent programs in aging research.

• To deepen the commitment of research institutions to academic research in aging and to translating research outcomes to geriatric medicine by involving mentor and recipient in establishing and advancing the recipient's career in aging research.

The broad fields of research appropriate for this K08 announcement include work in the basic sciences including animal models of aging or the use of secondary data analyses where there is apparent clinical relevance. Other examples include but are not limited to:

• The elucidation of basic biochemical, genetic, and physiological mechanisms underlying aging and age-related changes in humans and in appropriate animal models;

• Investigations focused on basic social and behavioral influences on the aging process, both at the individual and societal levels; models of transplantation in older patients; the utility and challenges of Medicare

• Research on the neural and behavioral processes associated with the aging brain, including brain-behavior biomarkers and behavior in models of Alzheimer's disease

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=203133

The purpose of this Funding Opportunity Announcement is to encourage new ideas for eliminating cellular reservoirs of HIV that continue to actively produce virus in tissue compartments despite suppression of plasma viremia with antiretroviral therapy. New approaches to delivering antiretrovirals or other anti-HIV agents to these tissues or to specific cell types are needed to block virus production, limit inflammation, and facilitate clearance of these reservoir cells.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=144294

The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, encourages grant applications from institutions/organizations that address the long term goal and objectives of increasing the safety and efficacy of non-vaccine biomedical prevention, such as microbicides and PrEP, through a better understanding of their interactions with the tissue micro- and macro-environments of the genital (male and female) and gastrointestinal mucosa.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=144014

Glycans play key roles in the transmission, antigenicity, and immunogenicity of the HIV-1 envelope protein. Glycans also modulate the immune response, playing an essential role in both innate and adaptive immunity.

The purpose of this Funding Opportunity Announcement (FOA) is to stimulate and foster multi-disciplinary investigator- initiated collaborative research to

1) investigate structural and conformational features of glycosylation that may lead to novel HIV vaccine design approaches, and

2) to elucidate the impact of differential glycosylation on the quality of the immune response to HIV.

Ultimately, the discovery of a safe, effective, prophylactic vaccine that provides long-term protection from HIV infection may depend on novel approaches that incorporate new knowledge of the key role glycans play in the elicitation and maturation of broadly neutralizing antibodies and effector immune responses.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=144013

The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research focused on the discovery of mechanisms that mediate the induction and maintenance of effective antigen-specific CD8+ memory T cells in the female reproductive tract (FRT).

The ultimate goal is to develop the knowledge base needed to facilitate the development of future vaccines that generate effective and persistent T lymphocyte responses against infection by HIV and other mucosal pathogens in the FRT. This program is not intended to support evaluation of mucosal vaccines or therapies, or research primarily focused on pathogens.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=143993

This ROSES program element for Astrophysics Explorer U.S. Participating Investigator (APEX USPI) is released in conjunction with the Second Stand Alone Mission of Opportunity Notice (SALMON-2) Announcement of Opportunity (AO) Program Element Amendment (PEA) L: Astrophysics Explorer Mission of Opportunity.

The purpose is to solicit potential Astrophysics Explorer Mission of Opportunity (MO) investigations in which investigators participate as a Co-I for an instrument, experiment, or technology demonstration that is being built and flown by a sponsor agency other than NASA.

The NASA Science Mission Directorate (SMD) addresses these strategic goals by conducting programs of astrophysics science designed to address the following science research objectives:

• Understand the origin and destiny of the universe and the nature of black holes, dark energy, dark matter, and gravity;

• Understand the many phenomena and processes associated with galaxy, stellar, and planetary system formation and evolution from the earliest epochs to today; and,

• Generate a census of extra-solar planets and measure their properties.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=204394

The Joint Center's goal is to accelerate the abilities of NOAA, DoD, and NASA to ingest and effectively use the large volumes of data from current satellite-based instruments and planned satellite missions.

The JCSDA supports scientific development work in the following priority areas (1) Radiative transfer, (2) Clouds and precipitation, (3) Advanced instruments data assimilation, (4) Land data assimilation, (5) Ocean data assimilation and (6) Air Composition data assimilation.

JCSDA research is performed internally (internal research) as well as externally using grants and/or contracts awarded via a competitive process open to the broader scientific community (external research). The overarching goal of JCSDA research is to accelerate the assimilation of satellite data in US operational numerical environment forecast models.

A primary measure of potential impact in this solicitation will be the acceleration of satellite data usage into NOAA, and DoD forecast systems, and the improvement of forecasts from those systems.

Link: http://www07.grants.gov/search/search.do?&mode=VIEW&oppId=204293