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- In exchange for a two or three-year (for Intramural General Research) commitment to your research career, NIH will repay up to $35,000 per year of your qualified educational debt. See NIH Loan Repayment Programs
Research in NIAMS Labs
Updated January 28, 2013
Welcome to NIAMS Labs from Dr. John O'Shea, NIAMS Scientific Director
As you will see, our program comprises scientists, physicians, nurses, trainees and administrators who work together to solve basic scientific problems and devise new treatments for arthritis, musculoskeletal and skin diseases.
Click here to read the welcome message from the Scientific Director
Casellas Group Develops a New DNA Damage Visualization Technique and Sheds Light on DNA Damage & Class Switching in Two Papers
The technique consists of detecting by immunoprecipitation and deep-sequencing recruitment of RPA to DNA breaks under conditions where homologous recombination is favored.
Cell Rep. 2013 Jan 1. doi:pii: S2211-1247(12)00431-7. 10.1016
Science. 2013 Jan 10.
Read the Cell Reports abstract and the Science abstract.
Dr. Steven Group Solves the Crystal Structure of Hepatitis B Virus e-antigen
The structure sheds light on a three-decades mystery and offers insight into how HBV e-antigen may establish immune tolerance for HBV core-antigen while evading its robust immunogenicity.
Structure . 2012 Dec 5. pii: S0969-2126(12)00414-5. doi: 10.1016/j.str.2012.10.017.
Read the abstract and the media availability.
Dr. O'Shea's Lab Shows Distinct Requirements for T-bet in Gut Innate Lymphoid Cells.
The study shows that the transcription facotr T-bet is important for innate lymphoid cells in the gut and plays a selective and critical role in the generation of a specific natural killer cells subset
J Exp Med . 2012 Dec 3.
Read the abstract.
Drs. O'Shea and Sartorelli Show a Critical Role of STATs as Environmental Sensors Shaping T Cell Populations
Signaling pathways are intimately involved in cellular differentiation, allowing cells to respond to their environment by regulating gene expression. The paper shows that STATs aare criticial for molding the specialized enhancer architecture of differentiating cells.
Cell. 2012 Nov 21;151(5):981-93. doi: 10.1016/j.cell.2012.09.044.
Read the abstract.
Clinical and Translational Research
- NIAMS Clinical Trials and Natural History Studies at the NIH Campus
- NIAMS Sponsored Clinical Trials
- For all clinical trials click here
IRP News and Events
- NIH scientists shed light on mystery surrounding Hepatitis B virus discovery is decades in the making. More..
- NIH scientists uncover how immune cells sense who they are. More...
- New rheumatoid arthritis drug targets NIH-discovered protein. More...
- Major cancer protein amplifies global gene expression, NIH study finds. More...