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Bioanalytical Science Group
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Welcome
We provide the measurement science, standards, technology, and data required to support the nation's needs in determining the composition, structure, quantity, and function of proteins, peptides, post-translational modifications such as glycosylation and phosphorylation, and related biomolecules such as metabolites. In partnership with U.S. industry, government agencies, and scientific institutions, the group performs fundamental and applied research on the characterization and quantitation of proteins, peptides, and their mixtures using techniques such as mass spectrometry, liquid chromatography, electrophoresis, and immunoassays. The Group provides measurement science, reference materials, reference data, and technologies to support accuracy and comparability of measurements needed to advance biotechnology, biomedical and bioscience research, biomanufacturing, and health care. Specific areas of interest include measurements and standards for clinical diagnostics and biotherapeutics. Programs/Projects
Reference Measurement Procedures and Materials for Creatinine— Chronic kidney disease (CKD) is a growing problem in the U.S., and current estimates suggest that more than 20 million Americans are affected by this disease. If left untreated, kidney disease can … Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum— Hormones are chemical messengers that regulate many life functions, and deviations from normal levels can indicate serious health problems. Measurement of levels of steroid and/or thyroid hormones … Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers — The accuracy of clinical diagnostic measurements is essential for reliable diagnosis and cost-effective treatment of disease. NIST's involvement in reference methods and reference materials to … Development of a Standard Reference Material for Metabolites in Plasma — Metabolomics is a relatively new field that builds upon work in genomics and proteomics. Metabolomics can provide a unique perspective on the biochemical status of an organism through broad … Development of Proteomics-Based Methods for Protein Quantification— NIST is developing methods for the quantification of clinically-relevant protein biomarkers by mass spectrometry. Some methods are intended to establish reference measurement procedures for the … Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum— Cardiac troponin I (cTnI) is considered the 'gold standard' for the diagnosis of myocardial infarction and the assessment of cardiac damage. Yet this clinical measurement is plagued with … Development of Standard Reference Materials for Vitamins B6 and B12 in Human Serum— Vitamins are essential to normal functioning of the human body because they serve as co-factors for important biological processes. Deficiencies in vitamins B6 and B12 can lead to problems such as … Development of Reference Methods and Reference Materials for Proteins — A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For example, measurement of the protein cardiac troponin … Improving Measurement Quality in Clinical Proteomics— Through collaboration with academic and government institutes, NIST is critically evaluating and attempting to improve measurement quality in clinical mass spectrometric proteomic investigations. … Development of Methods for Measurement of Vitamin D in Foods, Fortified Foods, and Dietary Supplements— Vitamin D is a fat-soluble vitamin that is essential for bone health. Vitamin D deficiency is associated with muscle weakness and osteoporosis and can contribute to an increased risk of falls and … Development of an Amino Acid (in Solution) Standard Reference Material— Amino acids are the sequential components of proteins and many are essential to our physiological well-being. Their quantification by the scientific community varies in technique and application. … Development of a Standard Reference Material for Vitamin D in Human Serum— The prevalence of vitamin D deficiency/insufficiency within the general population is an area of concern. Vitamin D status is generally assessed by measuring levels of the metabolite … Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum— C-reactive protein (CRP) levels in serum or plasma have been used as an indicator of inflammation and infection. Recent evidence also suggests that CRP levels may have value in identifying … Chromatographic Separation of Unfolded Proteins for Protein Quantification— NIST is developing methods for the quantification of protein biomarkers by mass spectrometry (MS). Stable isotope labeling of proteins/peptides followed by MS analysis allows relative … |
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