IXIARO® is an inactivated virus vaccine injected intramuscularly in a two-dose series. Doses are administered on day zero (the day of initial immunization) and on day twenty-eight. All patients receive 0.5 mL per dose. The IXIARO® series should be completed at least 1 week prior to potential exposure to JEV. The need for and timing of booster doses is not known at this time.

You cannot use IXIARO® as a booster dose for previously administered JE-Vax®. Explain to the patient that their previous doses of JE-Vax® are void and they will have to complete the two dose series of IXIARO® administration for protection against JE.

The most common side effects are headache, muscle pain and injection site reactions (e.g., pain, swelling, tenderness, redness). Nausea, skin rash, fatigue, flu-like illness, and fever may also occur. Contact your health care provider if you have any of the following problems because these may be signs of an allergic reaction:

• difficulty breathing
• hoarseness or wheezing
• hives
• dizziness, weakness or fast heart beat