Military taking steps to limit use of antipsychotics for PTSD

May 14, 2012|By David Sell, INQUIRER STAFF WRITER
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  • Stan and Shirley White of W.Va., whose son Andrew, a Marine, suffered from PTSD. When he died in 2008 at 23, they blamed a “lethal cocktail” of drugs. They were in Phila. fighting the use of antipsychotics for service people. DAVID SELL / Staff
  • Stan and Shirley White of W.Va., whose son Andrew, a Marine, suffered from PTSD. When he died in 2008 at 23, they blamed a “lethal cocktail” of drugs. They were in Phila. fighting the use of antipsychotics for service people. DAVID SELL / Staff
  • Stan and Shirley White’s three sons: (from left) William, Navy; Andrew R, Marines; and Robert, Army. The family photo was taken at Christmas 2004, the last time the brothers were together. Andrew, who was discharged with PTSD, died in 2008.
  • Marine corporal Andrew White (right) and Cpl. Seth Montgomery near some of the mines they helped defuse while serving in Iraq with the Marines in 2005. COURTESY OF THE WHITE FAMILY
  • At the American Psychiatric Association convention this month in Philadelphia, drugmaker AstraZeneca had a product display of Seroquel XR, its antipsychotic drug. DAVID SELL / Staff

Concerned about “suspicions” of overprescribing antipsychotic drugs, the Pentagon took steps in the last few weeks to limit the use of those powerful medicines to treat the growing legion of war fighters suffering from post-traumatic stress disorder.

For Stan and Shirley White, the limits can’t go into effect soon enough because, in their case, it’s already too late.

The retired educators’ youngest son, Andrew, was an Eagle scout, a baseball player, and an honor student in high school near the family home in Cross Lanes, W.Va.

Following his brothers into the military, Andrew joined the Marine Corps Reserve. His unit went to Iraq in January 2005.

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During about 300 missions, Andrew had a steady diet of death and destruction.

A combat engineer, Andrew cleared mines and improvised explosive devices from roads before they blew up his fellow Marines, soldiers, and civilians. After nine months, White was sent home and eventually received a medical discharge for PTSD.

“It changed him,” Stan White said of combat. “He became a recluse. In the last four months of his life, he ate two meals with the family. He would take his food to his room.”

On Feb. 12, 2008, when Andrew had failed to meet her for a planned lunch at a restaurant, Shirley White went home. She found him dead in his bed. He was 23.

The problem, Stan White said, is that Andrew had been taking what the father called a “lethal cocktail” of Paxil, Klonopin, and Seroquel, prescribed by the doctor treating Andrew at a nearby Veterans Administration hospital. Paxil is an antidepressant. Klonopin, generally prescribed for panic disorder, is in a group of drugs that military officials now discourage using.

Seroquel, an antipsychotic, is made by AstraZeneca P.L.C., a global drugmaker with U.S. headquarters in Wilmington. After initially taking 25 milligrams of Seroquel per day, Andrew was taking 1,600 mg per day when he died, his father said.

Andrew had episodes of problem drinking, but the coroner found no alcohol in his system and attributed his death to an accidental intoxication of drugs, Stan White said.

The 40 pounds that Andrew gained is one of the known side effects of antipsychotic drugs like Seroquel.

“We don’t think they should be given to troops in the field,” Stan White said. “It’s worth asking whether they should be given to anybody anytime, civilian or military.”

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