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<title>Genomics|Population Research|U.S. Genome Variation Estimates|Frequencies

U.S. Genome Variation Estimates

TNF Allele and Genotype Frequencies
 Available polymorphism(s)
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rs number

Common Designations

             Nucleotide change               Amino acid change

Genotyping method

rs1800629

-487G>A
-308G>A

 

TaqMan

rs1800750

-555G>A

 

TaqMan

rs361525

-417G>A
 -238G>A

 

TaqMan

 


 Allele and Genotype Frequencies for Subpopulations

 

BY RACE/ETHNICITY    [top]

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs1800629 A G   AA AG GG    
  Non-Hispanic White 17.2 (15.6, 19.0) 82.8 (81.0, 84.4) <0.001 2.9 (2.1, 4.0) 28.7 (26.1, 31.5) 68.4 (65.4, 71.3) <0.001 0.78
  Non-Hispanic Black 13.1 (11.9, 14.5) 86.9 (85.5, 88.1) 1.8 (1.3, 2.5) 22.7 (20.8, 24.6) 75.5 (73.2, 77.7) 0.87
  Mexican American 7.3 (5.9, 9.1) 92.7 (90.9, 94.1) 0.5 (0.3, 0.8) 13.6 (10.8, 16.9) 85.9 (82.5, 88.7) 0.88
  Total* 15.3 (14.0, 16.8) 84.7 (83.2, 86.0)   2.4 (1.8, 3.2) 25.9 (23.7, 28.2) 71.7 (69.2, 74.1)    
rs1800750 A G   AA AG GG    
  Non-Hispanic White 1.3 (0.9, 2.0) 98.7 (98.0, 99.1) 0.007 0.1 (0.0, 0.2) 2.5 (1.6, 3.9) 97.4 (96.0, 98.3) <0.001 <0.01
  Non-Hispanic Black 2.3 (1.9, 2.9) 97.7 (97.1, 98.1) 0.1 (0.0, 0.3) 4.5 (3.6, 5.6) 95.4 (94.3, 96.3) 0.41
  Mexican American 2.5 (2.1, 2.9) 97.5 (97.1, 97.9) 0.0 (NA) 5.0 (4.3, 5.7) 95.0 (94.3, 95.7) 0.22
  Total* 1.6 (1.2, 2.1) 98.4 (97.9, 98.8)   0.1 (0.0, 0.2) 3.0 (2.3, 4.1) 96.9 (95.8, 97.7)    
rs361525 A G   AA AG GG    
  Non-Hispanic White 5.8 (5.0, 6.6) 94.2 (93.4, 95.0) 0.005 0.7 (0.4, 1.1) 10.1 (8.9, 11.4) 89.2 (87.7, 90.5) 0.022 0.06
  Non-Hispanic Black 4.1 (3.3, 5.2) 95.9 (94.8, 96.7) 0.1 (0.0, 0.6) 8.0 (6.4, 9.8) 91.9 (89.9, 93.5) 0.53
  Mexican American 5.8 (5.2, 6.5) 94.2 (93.5, 94.8) 0.2 (0.1, 0.5) 11.2 (9.9, 12.6) 88.6 (87.2, 89.8) 0.20
  Total* 5.5 (4.9, 6.2) 94.5 (93.8, 95.1)   0.5 (0.4, 0.8) 10.0 (8.8, 11.2) 89.5 (88.2, 90.7)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

 

BY AGE*  [top]

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1800629 A G   AA AG GG  
  12-19 14.9 (12.1, 18.1) 85.1 (81.9, 87.9) 0.579 0.9 (0.3, 2.4) 27.9 (22.6, 33.8) 71.2 (65.1, 76.6) 0.004
  20-39 15.8 (13.5, 18.5) 84.2 (81.5, 86.5) 2.8 (1.7, 4.6) 26.1 (22.4, 30.1) 71.1 (66.7, 75.1)
  40-59 14.4 (12.4, 16.6) 85.6 (83.4, 87.6) 2.8 (2.0, 3.9) 23.1 (19.8, 26.9) 74.0 (70.1, 77.6)
  >=60 16.1 (14.3, 18.0) 83.9 (82.0, 85.7) 2.1 (1.3, 3.5) 27.9 (24.5, 31.6) 70.0 (66.4, 73.3)
  Total 15.3 (14.0, 16.8) 84.7 (83.2, 86.0)   2.4 (1.8, 3.2) 25.9 (23.7, 28.2) 71.7 (69.2, 74.1)  
rs1800750 A G   AA AG GG  
  12-19 1.2 (0.6, 2.2) 98.8 (97.8, 99.4) 0.743 0.0 (NA) 2.3 (1.2, 4.4) 97.7 (95.6, 98.8) 0.103
  20-39 1.6 (1.1, 2.3) 98.4 (97.7, 98.9) 0.1 (0.0, 0.5) 3.0 (2.1, 4.5) 96.9 (95.5, 97.8)
  40-59 1.6 (1.0, 2.6) 98.4 (97.4, 99.0) 0.0 (NA) 3.2 (2.0, 5.3) 96.8 (94.7, 98.0)
  >=60 1.8 (1.0, 3.4) 98.2 (96.6, 99.0) 0.2 (0.0, 0.9) 3.3 (1.7, 6.3) 96.5 (93.5, 98.2)
  Total 1.6 (1.2, 2.1) 98.4 (97.9, 98.8)   0.1 (0.0, 0.2) 3.0 (2.3, 4.1) 96.9 (95.8, 97.7)  
rs361525 A G   AA AG GG  
  12-19 5.2 (4.0, 6.7) 94.8 (93.3, 96.0) 0.277 0.0 (0.0, 0.3) 10.3 (7.9, 13.3) 89.7 (86.7, 92.0) <0.001
  20-39 6.3 (5.1, 7.7) 93.7 (92.3, 94.9) 1.0 (0.6, 1.6) 10.6 (8.6, 13.0) 88.4 (85.9, 90.6)
  40-59 4.8 (3.7, 6.2) 95.2 (93.8, 96.3) 0.4 (0.1, 1.3) 8.8 (6.8, 11.3) 90.8 (88.2, 92.9)
  >=60 5.3 (4.0, 6.9) 94.7 (93.1, 96.0) 0.3 (0.1, 0.9) 10.1 (7.5, 13.4) 89.7 (86.4, 92.2)
  Total 5.5 (4.9, 6.2) 94.5 (93.8, 95.1)   0.5 (0.4, 0.8) 10.0 (8.8, 11.2) 89.5 (88.2, 90.7)  

* Includes all participants, regardless of race/ethnicity.

 

BY SEX*  [top]

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1800629 A G   AA AG GG  
  Male 14.3 (12.5, 16.4) 85.7 (83.6, 87.5) 0.103 2.0 (1.3, 2.9) 24.7 (21.3, 28.5) 73.3 (69.5, 76.8) 0.233
  Female 16.3 (14.6, 18.2) 83.7 (81.8, 85.4) 2.8 (2.0, 4.1) 26.9 (24.3, 29.8) 70.2 (67.1, 73.1)
  Total 15.3 (14.0, 16.8) 84.7 (83.2, 86.0)   2.4 (1.8, 3.2) 25.9 (23.7, 28.2) 71.7 (69.2, 74.1)  
rs1800750 A G   AA AG GG  
  Male 1.6 (1.2, 2.3) 98.4 (97.7, 98.8) 0.762 0.1 (0.0, 0.5) 3.2 (2.2, 4.5) 96.8 (95.5, 97.7) 0.887
  Female 1.6 (1.1, 2.2) 98.4 (97.8, 98.9) 0.1 (0.0, 0.3) 2.9 (2.0, 4.2) 97.0 (95.7, 97.9)
  Total 1.6 (1.2, 2.1) 98.4 (97.9, 98.8)   0.1 (0.0, 0.2) 3.0 (2.3, 4.1) 96.9 (95.8, 97.7)  
rs361525 A G   AA AG GG  
  Male 5.0 (4.1, 6.0) 95.0 (94.0, 95.9) 0.050 0.3 (0.1, 0.9) 9.3 (7.8, 11.2) 90.4 (88.5, 92.0) 0.122
  Female 6.0 (5.3, 6.9) 94.0 (93.1, 94.7) 0.8 (0.5, 1.3) 10.5 (9.3, 11.9) 88.7 (87.2, 90.0)
  Total 5.5 (4.9, 6.2) 94.5 (93.8, 95.1)   0.5 (0.4, 0.8) 10.0 (8.8, 11.2) 89.5 (88.2, 90.7)  

* Includes all participants, regardless of race/ethnicity.

 

BY RACE/ETHNICITY AND AGE    [top]

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs1800629 A G AA AG GG
  Non-Hispanic White 12-19 16.8 (13.1, 21.3) 83.2 (78.7, 86.9) 0.7 (0.1, 4.8) 32.2 (25.1, 40.2) 67.1 (58.9, 74.3)
  20-39 18.3 (15.3, 21.7) 81.7 (78.3, 84.7) 3.7 (2.1, 6.4) 29.2 (24.3, 34.6) 67.1 (61.5, 72.3)
  40-59 16.4 (14.2, 18.7) 83.6 (81.3, 85.8) 3.3 (2.3, 4.6) 26.2 (22.6, 30.2) 70.5 (66.4, 74.4)
  >=60 17.0 (15.0, 19.1) 83.0 (80.9, 85.0) 2.3 (1.3, 4.0) 29.3 (25.4, 33.4) 68.4 (64.5, 72.1)
  Non-Hispanic Black 12-19 14.1 (11.5, 17.2) 85.9 (82.8, 88.5) 2.5 (1.2, 5.2) 23.3 (18.2, 29.3) 74.2 (68.6, 79.2)
  20-39 14.1 (12.2, 16.3) 85.9 (83.7, 87.8) 1.8 (1.1, 2.9) 24.7 (21.8, 28.0) 73.5 (69.8, 76.9)
  40-59 11.9 (10.2, 13.8) 88.1 (86.2, 89.8) 2.1 (1.1, 4.0) 19.6 (16.8, 22.8) 78.3 (75.1, 81.1)
  >=60 11.0 (8.4, 14.3) 89.0 (85.7, 91.6) 0.6 (0.1, 2.7) 20.8 (16.3, 26.1) 78.6 (72.8, 83.4)
  Mexican American 12-19 8.5 (5.2, 13.6) 91.5 (86.4, 94.8) 0.6 (0.1, 2.9) 15.8 (10.2, 23.6) 83.6 (74.9, 89.7)
  20-39 6.8 (5.4, 8.7) 93.2 (91.3, 94.6) 0.1 (0.0, 1.0) 13.4 (10.5, 17.0) 86.5 (82.9, 89.4)
  40-59 6.8 (4.9, 9.4) 93.2 (90.6, 95.1) 1.1 (0.6, 2.2) 11.3 (7.7, 16.3) 87.6 (82.6, 91.3)
  >=60 8.6 (5.9, 12.2) 91.4 (87.8, 94.1) 0.9 (0.3, 2.9) 15.4 (10.6, 21.8) 83.8 (77.1, 88.8)
rs1800750 A G AA AG GG
  Non-Hispanic White 12-19 1.0 (0.3, 2.8) 99.0 (97.2, 99.7) 0.0 (NA) 1.9 (0.7, 5.6) 98.1 (94.4, 99.3)
  20-39 1.5 (0.9, 2.6) 98.5 (97.4, 99.1) 0.1 (0.0, 0.8) 2.8 (1.5, 5.1) 97.1 (94.9, 98.4)
  40-59 1.2 (0.6, 2.6) 98.8 (97.4, 99.4) 0.0 (NA) 2.4 (1.1, 5.3) 97.6 (94.7, 98.9)
  >=60 1.4 (0.8, 2.6) 98.6 (97.4, 99.2) 0.2 (0.1, 1.1) 2.3 (1.2, 4.5) 97.4 (95.3, 98.6)
  Non-Hispanic Black 12-19 2.0 (1.2, 3.5) 98.0 (96.5, 98.8) 0.0 (NA) 4.1 (2.4, 6.9) 95.9 (93.1, 97.6)
  20-39 3.0 (2.3, 4.1) 97.0 (95.9, 97.7) 0.2 (0.0, 0.8) 5.7 (4.3, 7.6) 94.1 (92.1, 95.6)
  40-59 1.5 (0.8, 2.6) 98.5 (97.4, 99.2) 0.0 (NA) 2.9 (1.6, 5.3) 97.1 (94.7, 98.4)
  >=60 2.1 (1.0, 4.5) 97.9 (95.5, 99.0) 0.0 (NA) 4.2 (1.9, 8.9) 95.8 (91.1, 98.1)
  Mexican American 12-19 1.9 (1.3, 2.9) 98.1 (97.1, 98.7) 0.0 (NA) 3.9 (2.6, 5.7) 96.1 (94.3, 97.4)
  20-39 2.2 (1.6, 3.2) 97.8 (96.8, 98.4) 0.0 (NA) 4.4 (3.1, 6.3) 95.6 (93.7, 96.9)
  40-59 3.1 (1.9, 4.9) 96.9 (95.1, 98.1) 0.0 (NA) 6.1 (3.8, 9.8) 93.9 (90.2, 96.2)
  >=60 3.9 (2.5, 6.0) 96.1 (94.0, 97.5) 0.0 (NA) 7.7 (4.9, 12.0) 92.3 (88.0, 95.1)
rs361525 A G AA AG GG
  Non-Hispanic White 12-19 5.4 (3.9, 7.6) 94.6 (92.4, 96.1) 0.0 (NA) 10.9 (7.7, 15.2) 89.1 (84.8, 92.3)
  20-39 7.1 (5.6, 8.9) 92.9 (91.1, 94.4) 1.4 (0.8, 2.4) 11.4 (9.0, 14.2) 87.3 (84.1, 89.9)
  40-59 4.6 (3.4, 6.1) 95.4 (93.9, 96.6) 0.4 (0.1, 1.8) 8.4 (6.2, 11.2) 91.2 (88.4, 93.4)
  >=60 5.3 (4.3, 6.5) 94.7 (93.5, 95.7) 0.3 (0.1, 1.1) 10.0 (7.9, 12.5) 89.7 (87.3, 91.8)
  Non-Hispanic Black 12-19 5.1 (3.5, 7.4) 94.9 (92.6, 96.5) 0.0 (NA) 10.2 (7.0, 14.7) 89.8 (85.3, 93.0)
  20-39 4.7 (3.6, 6.1) 95.3 (93.9, 96.4) 0.0 (NA) 9.3 (7.1, 12.1) 90.7 (87.9, 92.9)
  40-59 3.1 (1.9, 5.0) 96.9 (95.0, 98.1) 0.5 (0.1, 2.5) 5.1 (3.1, 8.2) 94.4 (91.1, 96.4)
  >=60 3.0 (1.7, 5.2) 97.0 (94.8, 98.3) 0.0 (NA) 6.0 (3.4, 10.3) 94.0 (89.7, 96.6)
  Mexican American 12-19 5.5 (4.2, 7.0) 94.5 (93.0, 95.8) 0.4 (0.0, 2.9) 10.2 (7.9, 13.1) 89.4 (86.6, 91.7)
  20-39 6.2 (5.2, 7.4) 93.8 (92.6, 94.8) 0.0 (NA) 12.4 (10.4, 14.8) 87.6 (85.2, 89.6)
  40-59 5.1 (3.2, 8.1) 94.9 (91.9, 96.8) 0.6 (0.1, 2.5) 9.1 (5.9, 13.8) 90.4 (85.1, 93.9)
  >=60 6.3 (4.6, 8.6) 93.7 (91.4, 95.4) 0.5 (0.1, 3.4) 11.6 (8.8, 15.0) 87.9 (84.1, 90.9)

 

BY RACE/ETHNICITY AND SEX    [top]

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs1800629 A G AA AG GG
  Non-Hispanic White Male 16.2 (13.9, 18.7) 83.8 (81.3, 86.1) 2.4 (1.6, 3.6) 27.5 (23.4, 32.1) 70.1 (65.4, 74.4)
  Female 18.3 (16.0, 20.8) 81.7 (79.2, 84.0) 3.4 (2.2, 5.2) 29.8 (26.4, 33.5) 66.8 (62.8, 70.6)
  Non-Hispanic Black Male 11.7 (9.9, 13.8) 88.3 (86.2, 90.1) 1.1 (0.5, 2.2) 21.3 (18.3, 24.6) 77.6 (74.0, 80.9)
  Female 14.3 (12.8, 16.0) 85.7 (84.0, 87.2) 2.4 (1.8, 3.3) 23.8 (21.6, 26.1) 73.8 (71.1, 76.3)
  Mexican American Male 6.5 (4.8, 8.7) 93.5 (91.3, 95.2) 0.3 (0.1, 0.9) 12.3 (8.7, 17.0) 87.4 (82.8, 90.9)
  Female 8.2 (6.7, 9.9) 91.8 (90.1, 93.3) 0.7 (0.3, 1.4) 15.0 (12.3, 18.2) 84.3 (81.0, 87.1)
rs1800750 A G AA AG GG
  Non-Hispanic White Male 1.3 (0.9, 2.0) 98.7 (98.0, 99.1) 0.1 (0.0, 0.7) 2.5 (1.6, 3.8) 97.4 (96.1, 98.3)
  Female 1.3 (0.7, 2.4) 98.7 (97.6, 99.3) 0.1 (0.0, 0.5) 2.5 (1.3, 4.6) 97.4 (95.4, 98.6)
  Non-Hispanic Black Male 2.4 (1.7, 3.5) 97.6 (96.5, 98.3) 0.0 (NA) 4.9 (3.4, 7.0) 95.1 (93.0, 96.6)
  Female 2.3 (1.7, 3.0) 97.7 (97.0, 98.3) 0.1 (0.0, 0.6) 4.2 (3.1, 5.7) 95.6 (94.1, 96.8)
  Mexican American Male 2.6 (2.0, 3.2) 97.4 (96.8, 98.0) 0.0 (NA) 5.1 (4.0, 6.4) 94.9 (93.6, 96.0)
  Female 2.4 (1.8, 3.2) 97.6 (96.8, 98.2) 0.0 (NA) 4.8 (3.6, 6.4) 95.2 (93.6, 96.4)
rs361525 A G AA AG GG
  Non-Hispanic White Male 5.1 (4.2, 6.2) 94.9 (93.8, 95.8) 0.4 (0.1, 1.3) 9.5 (8.0, 11.3) 90.1 (88.2, 91.7)
  Female 6.3 (5.4, 7.4) 93.7 (92.6, 94.6) 1.0 (0.6, 1.7) 10.7 (9.3, 12.2) 88.3 (86.6, 89.8)
  Non-Hispanic Black Male 3.9 (3.0, 5.1) 96.1 (94.9, 97.0) 0.1 (0.0, 1.0) 7.6 (5.8, 10.0) 92.3 (89.9, 94.1)
  Female 4.3 (3.2, 5.7) 95.7 (94.3, 96.8) 0.1 (0.0, 1.2) 8.3 (6.2, 10.9) 91.6 (88.9, 93.7)
  Mexican American Male 5.2 (4.2, 6.5) 94.8 (93.5, 95.8) 0.1 (0.0, 0.8) 10.2 (8.1, 12.7) 89.7 (87.2, 91.8)
  Female 6.5 (5.7, 7.4) 93.5 (92.6, 94.3) 0.4 (0.2, 0.7) 12.2 (10.6, 14.0) 87.4 (85.7, 89.0)
Page last reviewed: October 21, 2008 (archived document)
Page last updated: October 21, 2008
Content Source: National Office of Public Health Genomics