Genomics|Population Research|U.S. Genome Variation Estimates|Frequencies|NQO1

U.S. Genome Variation Estimates

NQO1 Allele and Genotype Frequencies

Available polymorphism(s)

rs number	Common Designations Nucleotide change Amino acid change		Genotyping method
rs10517	Ex6-457C>T		TaqMan
rs1800566	Ex6+40C>T 609C>T	Pro187Ser Pro149Ser Pro153Ser	TaqMan
rs34755915	IVS3+20G>A		TaqMan
rs689452	IVS1-27C>G		TaqMan
rs689453	Ex2+65G>A	Glu24Glu	TaqMan

Allele and Genotype Frequencies for Subpopulations

By Race/Ethnicity
By Age
By Sex
By Race/Ethnicity and Age
By Race/Ethnicity and Sex

BY RACE/ETHNICITY [top]

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs10517		C	T		CC	CT	TT
	Non-Hispanic White	86.8 (85.7, 87.9)	13.2 (12.1, 14.3)	<0.001	75.5 (73.5, 77.3)	22.8 (21.0, 24.7)	1.8 (1.2, 2.6)	0.001	0.65
	Non-Hispanic Black	86.1 (84.6, 87.5)	13.9 (12.5, 15.4)		73.9 (71.4, 76.3)	24.3 (22.2, 26.6)	1.7 (1.1, 2.7)		0.65
	Mexican American	93.5 (91.7, 94.9)	6.5 (5.1, 8.3)		87.2 (83.8, 90.0)	12.6 (9.8, 16.0)	0.2 (0.1, 0.5)		0.20
	Total*	86.4 (85.1, 87.7)	13.6 (12.3, 14.9)		75.0 (73.0, 77.0)	22.9 (21.4, 24.4)	2.1 (1.5, 3.0)
rs1800566		C	T		CC	CT	TT
	Non-Hispanic White	80.6 (78.7, 82.4)	19.4 (17.6, 21.3)	<0.001	64.7 (61.2, 68.0)	31.8 (28.7, 35.1)	3.5 (2.8, 4.3)	<0.001	0.51
	Non-Hispanic Black	81.2 (80.0, 82.3)	18.8 (17.7, 20.0)		65.8 (64.1, 67.5)	30.7 (29.1, 32.3)	3.5 (2.7, 4.6)		0.93
	Mexican American	63.2 (61.2, 65.1)	36.8 (34.9, 38.8)		40.4 (37.5, 43.4)	45.6 (42.8, 48.4)	14.0 (12.4, 15.8)		0.93
	Total*	78.5 (76.8, 80.2)	21.5 (19.8, 23.2)		61.8 (58.8, 64.7)	33.4 (30.8, 36.2)	4.8 (4.1, 5.6)
rs34755915		A	G		AA	AG	GG

	Non-Hispanic White	1.8 (1.5, 2.3)	98.2 (97.7, 98.5)	<0.001	0.0 (0.0, 0.4)	3.5 (2.9, 4.4)	96.4 (95.6, 97.1)	<0.001	0.81
	Non-Hispanic Black	0.4 (0.2, 0.8)	99.6 (99.2, 99.8)		0.0 (NA)	0.8 (0.4, 1.6)	99.2 (98.4, 99.6)		0.88
	Mexican American	0.5 (0.3, 0.9)	99.5 (99.1, 99.7)		0.0 (NA)	1.1 (0.6, 1.8)	98.9 (98.2, 99.4)		0.82
	Total*	1.4 (1.1, 1.8)	98.6 (98.2, 98.9)		0.0 (0.0, 0.3)	2.8 (2.2, 3.5)	97.2 (96.5, 97.8)
rs689452		C	G		CC	CG	GG
	Non-Hispanic White	88.1 (87.1, 89.0)	11.9 (11.0, 12.9)	<0.001	77.5 (75.7, 79.3)	21.1 (19.4, 23.0)	1.3 (0.9, 2.0)	<0.001	0.23
	Non-Hispanic Black	86.3 (84.7, 87.7)	13.7 (12.3, 15.3)		74.2 (71.7, 76.6)	24.1 (21.9, 26.4)	1.7 (1.1, 2.6)		0.63
	Mexican American	93.7 (91.8, 95.1)	6.3 (4.9, 8.2)		87.5 (83.9, 90.4)	12.3 (9.4, 15.8)	0.2 (0.1, 0.5)		0.25
	Total*	87.5 (86.3, 88.6)	12.5 (11.4, 13.7)		76.6 (74.8, 78.4)	21.6 (20.2, 23.2)	1.7 (1.2, 2.5)
rs689453		A	G		AA	AG	GG
	Non-Hispanic White	7.9 (6.7, 9.2)	92.1 (90.8, 93.3)	<0.001	0.5 (0.2, 1.1)	14.7 (12.7, 17.0)	84.8 (82.4, 86.9)	0.005	0.23
	Non-Hispanic Black	5.1 (4.2, 6.2)	94.9 (93.8, 95.8)		0.4 (0.1, 1.1)	9.5 (7.5, 11.9)	90.2 (87.9, 92.1)		0.25
	Mexican American	5.2 (3.8, 7.0)	94.8 (93.0, 96.2)		0.6 (0.3, 1.3)	9.2 (7.1, 12.0)	90.2 (87.0, 92.6)		0.21
	Total*	7.0 (6.1, 8.1)	93.0 (91.9, 93.9)		0.4 (0.2, 0.9)	13.2 (11.4, 15.1)	86.4 (84.4, 88.2)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

BY AGE^* [top]

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs10517		C	T		CC	CT	TT
	12-19	85.7 (83.4, 87.8)	14.3 (12.2, 16.6)	0.894	74.3 (70.3, 77.8)	22.9 (19.2, 27.1)	2.8 (1.4, 5.4)	0.864
	20-39	86.7 (84.3, 88.7)	13.3 (11.3, 15.7)		75.2 (71.4, 78.7)	22.9 (20.0, 26.1)	1.9 (1.2, 3.0)
	40-59	86.3 (84.4, 88.1)	13.7 (11.9, 15.6)		74.7 (71.4, 77.8)	23.2 (20.2, 26.6)	2.0 (1.2, 3.6)
	>=60	86.6 (84.7, 88.3)	13.4 (11.7, 15.3)		75.5 (72.4, 78.4)	22.2 (19.5, 25.2)	2.3 (1.2, 4.1)
	Total	86.4 (85.1, 87.7)	13.6 (12.3, 14.9)		75.0 (73.0, 77.0)	22.9 (21.4, 24.4)	2.1 (1.5, 3.0)
rs1800566		C	T		CC	CT	TT
	12-19	76.1 (72.2, 79.5)	23.9 (20.5, 27.8)	0.108	57.5 (50.9, 63.9)	37.1 (31.0, 43.6)	5.4 (3.8, 7.6)	0.185
	20-39	77.9 (75.5, 80.1)	22.1 (19.9, 24.5)		61.1 (57.2, 65.0)	33.5 (30.1, 37.1)	5.4 (4.3, 6.7)
	40-59	80.1 (77.3, 82.6)	19.9 (17.4, 22.7)		64.2 (59.3, 68.7)	31.9 (27.5, 36.6)	4.0 (2.8, 5.6)
	>=60	79.3 (77.1, 81.4)	20.7 (18.6, 22.9)		62.9 (59.2, 66.5)	32.9 (29.5, 36.4)	4.2 (3.2, 5.6)
	Total	78.5 (76.8, 80.2)	21.5 (19.8, 23.2)		61.8 (58.8, 64.7)	33.4 (30.8, 36.2)	4.8 (4.1, 5.6)
rs34755915		A	G		AA	AG	GG
	12-19	1.4 (0.7, 2.8)	98.6 (97.2, 99.3)	0.969	0.0 (NA)	2.7 (1.3, 5.6)	97.3 (94.4, 98.7)	0.976
	20-39	1.4 (0.9, 2.2)	98.6 (97.8, 99.1)		0.0 (NA)	2.8 (1.8, 4.4)	97.2 (95.6, 98.2)
	40-59	1.4 (0.9, 2.1)	98.6 (97.9, 99.1)		0.0 (NA)	2.8 (1.8, 4.2)	97.2 (95.8, 98.2)
	>=60	1.5 (1.0, 2.4)	98.5 (97.6, 99.0)		0.2 (0.0, 1.5)	2.7 (1.9, 3.9)	97.1 (95.7, 98.0)
	Total	1.4 (1.1, 1.8)	98.6 (98.2, 98.9)		0.0 (0.0, 0.3)	2.8 (2.2, 3.5)	97.2 (96.5, 97.8)
rs689452		C	G		CC	CG	GG
	12-19	86.9 (84.9, 88.7)	13.1 (11.3, 15.1)	0.923	76.2 (72.8, 79.3)	21.3 (17.9, 25.2)	2.5 (1.2, 5.1)	0.867
	20-39	87.6 (85.5, 89.5)	12.4 (10.5, 14.5)		76.6 (73.2, 79.7)	22.0 (19.4, 24.7)	1.4 (0.8, 2.5)
	40-59	87.4 (85.7, 89.0)	12.6 (11.0, 14.3)		76.6 (73.4, 79.5)	21.7 (18.8, 25.0)	1.7 (0.9, 3.2)
	>=60	87.6 (85.7, 89.3)	12.4 (10.7, 14.3)		77.1 (73.8, 80.1)	21.1 (18.3, 24.3)	1.8 (1.0, 3.2)
	Total	87.5 (86.3, 88.6)	12.5 (11.4, 13.7)		76.6 (74.8, 78.4)	21.6 (20.2, 23.2)	1.7 (1.2, 2.5)
rs689453		A	G		AA	AG	GG
	12-19	7.4 (5.2, 10.3)	92.6 (89.7, 94.8)	0.205	0.8 (0.2, 2.5)	13.2 (9.2, 18.6)	86.0 (80.6, 90.1)	0.090
	20-39	6.2 (5.2, 7.5)	93.8 (92.5, 94.8)		0.3 (0.1, 1.0)	11.8 (9.7, 14.3)	87.9 (85.4, 89.9)
	40-59	7.6 (6.5, 9.0)	92.4 (91.0, 93.5)		0.3 (0.1, 1.0)	14.7 (12.6, 17.1)	85.0 (82.5, 87.2)
	>=60	7.5 (6.2, 9.0)	92.5 (91.0, 93.8)		0.7 (0.3, 1.4)	13.6 (11.1, 16.6)	85.7 (82.8, 88.2)
	Total	7.0 (6.1, 8.1)	93.0 (91.9, 93.9)		0.4 (0.2, 0.9)	13.2 (11.4, 15.1)	86.4 (84.4, 88.2)

* Includes all participants, regardless of race/ethnicity.

BY SEX^* [top]

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs10517		C	T		CC	CT	TT
	Male	86.1 (84.2, 87.7)	13.9 (12.3, 15.8)	0.500	74.1 (71.2, 76.9)	23.8 (21.3, 26.5)	2.0 (1.1, 3.6)	0.696
	Female	86.8 (85.0, 88.4)	13.2 (11.6, 15.0)		75.8 (72.6, 78.8)	22.0 (19.2, 25.0)	2.2 (1.7, 2.9)
	Total	86.4 (85.1, 87.7)	13.6 (12.3, 14.9)		75.0 (73.0, 77.0)	22.9 (21.4, 24.4)	2.1 (1.5, 3.0)
rs1800566		C	T		CC	CT	TT
	Male	78.7 (76.2, 81.0)	21.3 (19.0, 23.8)	0.770	61.8 (57.5, 65.9)	33.8 (29.8, 38.1)	4.4 (3.2, 6.0)	0.694
	Female	78.4 (76.7, 79.9)	21.6 (20.1, 23.3)		61.9 (59.0, 64.7)	33.0 (30.3, 35.9)	5.1 (4.3, 6.0)
	Total	78.5 (76.8, 80.2)	21.5 (19.8, 23.2)		61.8 (58.8, 64.7)	33.4 (30.8, 36.2)	4.8 (4.1, 5.6)
rs34755915		A	G		AA	AG	GG
	Male	1.6 (1.2, 2.1)	98.4 (97.9, 98.8)	0.320	0.0 (NA)	3.1 (2.4, 4.2)	96.9 (95.8, 97.6)	0.206
	Female	1.3 (0.9, 1.8)	98.7 (98.2, 99.1)		0.1 (0.0, 0.5)	2.4 (1.8, 3.3)	97.5 (96.5, 98.2)
	Total	1.4 (1.1, 1.8)	98.6 (98.2, 98.9)		0.0 (0.0, 0.3)	2.8 (2.2, 3.5)	97.2 (96.5, 97.8)
rs689452		C	G		CC	CG	GG
	Male	87.2 (85.5, 88.7)	12.8 (11.3, 14.5)	0.545	76.0 (73.4, 78.5)	22.3 (20.1, 24.6)	1.7 (0.9, 3.1)	0.815
	Female	87.8 (86.2, 89.2)	12.2 (10.8, 13.8)		77.2 (74.4, 79.9)	21.1 (18.5, 23.9)	1.7 (1.2, 2.5)
	Total	87.5 (86.3, 88.6)	12.5 (11.4, 13.7)		76.6 (74.8, 78.4)	21.6 (20.2, 23.2)	1.7 (1.2, 2.5)
rs689453		A	G		AA	AG	GG
	Male	7.6 (6.2, 9.3)	92.4 (90.7, 93.8)	0.086	0.6 (0.3, 1.5)	13.9 (11.4, 16.9)	85.4 (82.3, 88.1)	0.252
	Female	6.5 (5.7, 7.3)	93.5 (92.7, 94.3)		0.3 (0.1, 0.6)	12.4 (10.9, 14.1)	87.3 (85.6, 88.9)
	Total	7.0 (6.1, 8.1)	93.0 (91.9, 93.9)		0.4 (0.2, 0.9)	13.2 (11.4, 15.1)	86.4 (84.4, 88.2)

* Includes all participants, regardless of race/ethnicity.

BY RACE/ETHNICITY AND AGE [top]

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs10517			C	T	CC	CT	TT
	Non-Hispanic White	12-19	85.9 (82.3, 88.9)	14.1 (11.1, 17.7)	74.5 (68.6, 79.5)	23.0 (18.6, 28.1)	2.6 (1.3, 5.0)
		20-39	86.7 (84.1, 89.0)	13.3 (11.0, 15.9)	74.8 (70.0, 79.1)	23.8 (19.7, 28.5)	1.4 (0.9, 2.1)
		40-59	87.0 (84.4, 89.2)	13.0 (10.8, 15.6)	76.0 (72.1, 79.6)	22.0 (18.9, 25.4)	2.0 (0.9, 4.4)
		>=60	87.3 (85.7, 88.8)	12.7 (11.2, 14.3)	76.4 (73.4, 79.1)	22.0 (19.2, 24.9)	1.7 (0.9, 3.1)
	Non-Hispanic Black	12-19	85.9 (82.8, 88.5)	14.1 (11.5, 17.2)	73.9 (68.6, 78.5)	24.0 (19.3, 29.4)	2.1 (0.8, 5.6)
		20-39	86.2 (84.1, 88.1)	13.8 (11.9, 15.9)	74.1 (70.4, 77.5)	24.2 (20.8, 28.0)	1.7 (0.8, 3.6)
		40-59	86.5 (84.2, 88.5)	13.5 (11.5, 15.8)	73.9 (69.7, 77.7)	25.3 (21.7, 29.3)	0.8 (0.3, 2.1)
		>=60	85.4 (81.5, 88.7)	14.6 (11.3, 18.5)	73.7 (66.5, 79.7)	23.6 (17.6, 30.8)	2.8 (1.4, 5.2)
	Mexican American	12-19	94.5 (90.5, 96.8)	5.5 (3.2, 9.5)	89.5 (82.3, 94.0)	9.9 (5.6, 16.8)	0.6 (0.1, 2.6)
		20-39	93.8 (92.3, 95.1)	6.2 (4.9, 7.7)	87.7 (84.7, 90.1)	12.3 (9.9, 15.3)	0.0 (NA)
		40-59	92.2 (89.6, 94.2)	7.8 (5.8, 10.4)	84.5 (79.4, 88.4)	15.4 (11.4, 20.5)	0.1 (0.0, 1.0)
		>=60	92.5 (90.1, 94.4)	7.5 (5.6, 9.9)	85.9 (82.0, 89.1)	13.2 (10.3, 16.8)	0.8 (0.2, 3.4)
rs1800566			C	T	CC	CT	TT
	Non-Hispanic White	12-19	78.1 (73.4, 82.1)	21.9 (17.9, 26.6)	60.2 (52.4, 67.5)	35.7 (28.9, 43.2)	4.1 (2.1, 7.6)
		20-39	80.9 (78.1, 83.3)	19.1 (16.7, 21.9)	64.6 (59.6, 69.3)	32.5 (28.1, 37.2)	2.9 (2.2, 3.9)
		40-59	81.4 (78.0, 84.4)	18.6 (15.6, 22.0)	66.8 (60.8, 72.3)	29.1 (23.8, 35.0)	4.1 (2.7, 6.1)
		>=60	80.6 (78.0, 83.0)	19.4 (17.0, 22.0)	64.5 (60.0, 68.7)	32.2 (28.5, 36.2)	3.3 (2.4, 4.6)
	Non-Hispanic Black	12-19	82.5 (80.2, 84.5)	17.5 (15.5, 19.8)	67.8 (63.6, 71.8)	29.2 (24.6, 34.3)	2.9 (1.5, 5.6)
		20-39	79.4 (77.6, 81.2)	20.6 (18.8, 22.4)	63.1 (59.7, 66.3)	32.7 (29.2, 36.4)	4.2 (3.0, 6.0)
		40-59	82.8 (79.5, 85.7)	17.2 (14.3, 20.5)	68.1 (62.2, 73.4)	29.5 (24.4, 35.1)	2.5 (1.4, 4.4)
		>=60	81.9 (78.6, 84.7)	18.1 (15.3, 21.4)	67.6 (62.6, 72.3)	28.5 (24.1, 33.3)	3.9 (2.1, 7.0)
	Mexican American	12-19	60.6 (56.1, 64.9)	39.4 (35.1, 43.9)	39.4 (32.9, 46.3)	42.3 (35.5, 49.4)	18.3 (14.4, 22.9)
		20-39	64.5 (62.3, 66.7)	35.5 (33.3, 37.7)	42.4 (39.3, 45.6)	44.3 (41.5, 47.2)	13.3 (11.5, 15.3)
		40-59	61.9 (58.8, 64.8)	38.1 (35.2, 41.2)	36.2 (31.6, 41.1)	51.4 (45.4, 57.2)	12.4 (9.3, 16.5)
		>=60	64.7 (60.8, 68.4)	35.3 (31.6, 39.2)	41.5 (35.7, 47.6)	46.4 (40.5, 52.4)	12.1 (9.2, 15.9)
rs34755915			A	G	AA	AG	GG
	Non-Hispanic White	12-19	2.0 (0.9, 4.2)	98.0 (95.8, 99.1)	0.0 (NA)	4.0 (1.9, 8.4)	96.0 (91.6, 98.1)
		20-39	1.8 (1.2, 2.8)	98.2 (97.2, 98.8)	0.0 (NA)	3.7 (2.4, 5.6)	96.3 (94.4, 97.6)
		40-59	1.7 (1.1, 2.6)	98.3 (97.4, 98.9)	0.0 (NA)	3.4 (2.2, 5.3)	96.6 (94.7, 97.8)
		>=60	1.8 (1.2, 2.8)	98.2 (97.2, 98.8)	0.2 (0.0, 1.8)	3.2 (2.3, 4.5)	96.6 (95.0, 97.7)
	Non-Hispanic Black	12-19	0.1 (0.0, 0.7)	99.9 (99.3, 100.0)	0.0 (NA)	0.2 (0.0, 1.4)	99.8 (98.6, 100.0)
		20-39	0.6 (0.2, 1.7)	99.4 (98.3, 99.8)	0.0 (NA)	1.2 (0.4, 3.3)	98.8 (96.7, 99.6)
		40-59	0.3 (0.1, 1.0)	99.7 (99.0, 99.9)	0.0 (NA)	0.7 (0.2, 2.0)	99.3 (98.0, 99.8)
		>=60	0.3 (0.1, 1.4)	99.7 (98.6, 99.9)	0.0 (NA)	0.6 (0.2, 2.7)	99.4 (97.3, 99.8)
	Mexican American	12-19	0.5 (0.1, 2.2)	99.5 (97.8, 99.9)	0.0 (NA)	1.0 (0.2, 4.3)	99.0 (95.7, 99.8)
		20-39	0.6 (0.3, 1.2)	99.4 (98.8, 99.7)	0.0 (NA)	1.2 (0.6, 2.3)	98.8 (97.7, 99.4)
		40-59	0.5 (0.2, 1.6)	99.5 (98.4, 99.8)	0.0 (NA)	1.0 (0.3, 3.2)	99.0 (96.8, 99.7)
		>=60	0.5 (0.2, 1.3)	99.5 (98.7, 99.8)	0.0 (NA)	0.9 (0.3, 2.7)	99.1 (97.3, 99.7)
rs689452			C	G	CC	CG	GG
	Non-Hispanic White	12-19	87.3 (84.0, 90.0)	12.7 (10.0, 16.0)	76.6 (71.3, 81.2)	21.3 (17.2, 26.1)	2.0 (0.9, 4.5)
		20-39	88.0 (85.5, 90.1)	12.0 (9.9, 14.5)	77.0 (72.4, 80.9)	22.1 (18.3, 26.3)	1.0 (0.5, 1.8)
		40-59	88.3 (86.0, 90.2)	11.7 (9.8, 14.0)	78.1 (74.5, 81.4)	20.3 (17.3, 23.7)	1.6 (0.6, 4.1)
		>=60	88.5 (86.8, 90.0)	11.5 (10.0, 13.2)	78.2 (75.0, 81.1)	20.5 (17.7, 23.7)	1.2 (0.7, 2.3)
	Non-Hispanic Black	12-19	85.7 (82.6, 88.3)	14.3 (11.7, 17.4)	73.6 (68.3, 78.2)	24.3 (19.6, 29.7)	2.1 (0.8, 5.7)
		20-39	86.3 (84.4, 87.9)	13.7 (12.1, 15.6)	74.2 (70.8, 77.3)	24.2 (20.9, 27.8)	1.6 (0.8, 3.5)
		40-59	86.9 (84.5, 89.0)	13.1 (11.0, 15.5)	74.7 (70.3, 78.6)	24.5 (20.7, 28.6)	0.8 (0.3, 2.1)
		>=60	85.8 (81.8, 89.1)	14.2 (10.9, 18.2)	74.4 (67.0, 80.5)	22.9 (16.9, 30.2)	2.8 (1.4, 5.2)
	Mexican American	12-19	94.6 (90.8, 96.9)	5.4 (3.1, 9.2)	89.9 (82.9, 94.2)	9.5 (5.4, 16.1)	0.6 (0.1, 2.6)
		20-39	93.9 (92.2, 95.3)	6.1 (4.7, 7.8)	87.8 (84.4, 90.6)	12.2 (9.4, 15.6)	0.0 (NA)
		40-59	92.4 (89.9, 94.4)	7.6 (5.6, 10.1)	85.0 (80.1, 88.9)	14.9 (11.0, 19.8)	0.1 (0.0, 1.0)
		>=60	92.8 (90.0, 94.8)	7.2 (5.2, 10.0)	86.4 (81.7, 90.1)	12.7 (9.3, 17.1)	0.8 (0.2, 3.4)
rs689453			A	G	AA	AG	GG
	Non-Hispanic White	12-19	8.6 (5.5, 13.0)	91.4 (87.0, 94.5)	1.1 (0.3, 3.8)	14.9 (9.3, 23.0)	84.0 (75.8, 89.8)
		20-39	6.9 (5.6, 8.5)	93.1 (91.5, 94.4)	0.4 (0.1, 1.3)	13.1 (10.5, 16.2)	86.5 (83.5, 89.1)
		40-59	8.5 (7.0, 10.4)	91.5 (89.6, 93.0)	0.3 (0.1, 1.5)	16.5 (13.8, 19.8)	83.2 (79.8, 86.1)
		>=60	8.2 (6.7, 10.0)	91.8 (90.0, 93.3)	0.7 (0.3, 1.6)	15.0 (12.0, 18.5)	84.3 (80.9, 87.2)
	Non-Hispanic Black	12-19	5.5 (4.1, 7.3)	94.5 (92.7, 95.9)	0.3 (0.1, 1.1)	10.4 (7.6, 14.0)	89.3 (85.8, 92.1)
		20-39	4.3 (3.3, 5.5)	95.7 (94.5, 96.7)	0.2 (0.0, 0.7)	8.2 (6.3, 10.8)	91.6 (89.1, 93.6)
		40-59	5.3 (3.8, 7.5)	94.7 (92.5, 96.2)	0.5 (0.1, 3.6)	9.7 (6.6, 14.1)	89.8 (85.7, 92.9)
		>=60	6.6 (4.7, 9.2)	93.4 (90.8, 95.3)	0.8 (0.2, 3.4)	11.5 (7.5, 17.1)	87.7 (82.5, 91.5)
	Mexican American	12-19	5.0 (2.7, 9.1)	95.0 (90.9, 97.3)	0.0 (NA)	10.1 (5.4, 18.0)	89.9 (82.0, 94.6)
		20-39	5.5 (4.0, 7.5)	94.5 (92.5, 96.0)	0.7 (0.3, 1.8)	9.5 (7.1, 12.6)	89.8 (86.3, 92.5)
		40-59	5.6 (4.0, 7.8)	94.4 (92.2, 96.0)	0.8 (0.2, 3.1)	9.5 (6.6, 13.6)	89.7 (85.7, 92.6)
		>=60	3.1 (2.5, 3.9)	96.9 (96.1, 97.5)	0.6 (0.1, 3.8)	5.0 (3.2, 7.8)	94.4 (92.7, 95.7)

BY RACE/ETHNICITY AND SEX [top]

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs10517			C	T	CC	CT	TT
	Non-Hispanic White	Male	86.6 (84.8, 88.1)	13.4 (11.9, 15.2)	74.5 (71.0, 77.8)	24.1 (20.6, 28.0)	1.4 (0.8, 2.5)
		Female	87.1 (85.1, 88.8)	12.9 (11.2, 14.9)	76.3 (73.0, 79.4)	21.5 (18.8, 24.5)	2.1 (1.4, 3.2)
	Non-Hispanic Black	Male	85.2 (82.9, 87.2)	14.8 (12.8, 17.1)	72.0 (67.9, 75.8)	26.3 (22.7, 30.3)	1.7 (0.9, 3.2)
		Female	86.9 (84.5, 89.0)	13.1 (11.0, 15.5)	75.5 (71.6, 79.1)	22.7 (19.5, 26.3)	1.7 (0.8, 3.7)
	Mexican American	Male	93.8 (91.2, 95.7)	6.2 (4.3, 8.8)	87.7 (82.6, 91.5)	12.2 (8.4, 17.3)	0.1 (0.0, 0.7)
		Female	93.2 (91.5, 94.5)	6.8 (5.5, 8.5)	86.7 (83.5, 89.3)	13.0 (10.4, 16.1)	0.3 (0.1, 0.8)
rs1800566			C	T	CC	CT	TT
	Non-Hispanic White	Male	81.2 (78.7, 83.4)	18.8 (16.6, 21.3)	65.1 (60.3, 69.6)	32.2 (27.6, 37.3)	2.7 (1.8, 4.2)
		Female	80.1 (78.0, 82.0)	19.9 (18.0, 22.0)	64.3 (60.8, 67.7)	31.5 (28.2, 35.0)	4.2 (3.1, 5.7)
	Non-Hispanic Black	Male	80.6 (78.0, 82.9)	19.4 (17.1, 22.0)	65.2 (61.6, 68.5)	30.9 (28.0, 33.9)	4.0 (2.3, 6.8)
		Female	81.6 (80.4, 82.8)	18.4 (17.2, 19.6)	66.4 (64.3, 68.5)	30.5 (28.5, 32.6)	3.1 (2.5, 3.9)
	Mexican American	Male	62.1 (59.6, 64.6)	37.9 (35.4, 40.4)	38.8 (35.6, 42.1)	46.7 (43.7, 49.7)	14.5 (12.1, 17.3)
		Female	64.3 (61.8, 66.7)	35.7 (33.3, 38.2)	42.1 (38.2, 46.0)	44.4 (40.8, 48.2)	13.5 (11.7, 15.5)
rs34755915			A	G	AA	AG	GG
	Non-Hispanic White	Male	2.0 (1.5, 2.6)	98.0 (97.4, 98.5)	0.0 (NA)	4.0 (3.0, 5.3)	96.0 (94.7, 97.0)
		Female	1.7 (1.2, 2.3)	98.3 (97.7, 98.8)	0.1 (0.0, 0.7)	3.1 (2.3, 4.2)	96.8 (95.6, 97.6)
	Non-Hispanic Black	Male	0.5 (0.2, 1.3)	99.5 (98.7, 99.8)	0.0 (NA)	0.9 (0.4, 2.5)	99.1 (97.5, 99.6)
		Female	0.3 (0.2, 0.7)	99.7 (99.3, 99.8)	0.0 (NA)	0.7 (0.3, 1.4)	99.3 (98.6, 99.7)
	Mexican American	Male	0.6 (0.3, 1.3)	99.4 (98.7, 99.7)	0.0 (NA)	1.3 (0.6, 2.5)	98.7 (97.5, 99.4)
		Female	0.4 (0.3, 0.7)	99.6 (99.3, 99.7)	0.0 (NA)	0.9 (0.5, 1.4)	99.1 (98.6, 99.5)
rs689452			C	G	CC	CG	GG
	Non-Hispanic White	Male	87.9 (86.1, 89.4)	12.1 (10.6, 13.9)	76.9 (73.4, 80.0)	22.0 (18.8, 25.5)	1.2 (0.7, 2.0)
		Female	88.3 (86.6, 89.8)	11.7 (10.2, 13.4)	78.2 (75.2, 80.9)	20.3 (17.8, 23.1)	1.5 (0.9, 2.6)
	Non-Hispanic Black	Male	85.1 (82.7, 87.3)	14.9 (12.7, 17.3)	72.0 (67.6, 75.9)	26.4 (22.5, 30.6)	1.7 (0.9, 3.2)
		Female	87.2 (84.8, 89.3)	12.8 (10.7, 15.2)	76.1 (72.2, 79.6)	22.2 (19.1, 25.7)	1.7 (0.8, 3.6)
	Mexican American	Male	93.8 (91.2, 95.7)	6.2 (4.3, 8.8)	87.8 (82.6, 91.6)	12.1 (8.4, 17.3)	0.1 (0.0, 0.7)
		Female	93.5 (91.7, 94.9)	6.5 (5.1, 8.3)	87.3 (83.8, 90.1)	12.4 (9.6, 15.9)	0.3 (0.1, 0.8)
rs689453			A	G	AA	AG	GG
	Non-Hispanic White	Male	8.7 (7.0, 10.8)	91.3 (89.2, 93.0)	0.8 (0.3, 1.8)	15.9 (12.9, 19.5)	83.3 (79.5, 86.5)
		Female	7.0 (6.2, 8.0)	93.0 (92.0, 93.8)	0.3 (0.1, 0.7)	13.6 (11.8, 15.5)	86.2 (84.2, 87.9)
	Non-Hispanic Black	Male	4.5 (3.4, 5.9)	95.5 (94.1, 96.6)	0.2 (0.0, 1.0)	8.5 (6.2, 11.6)	91.3 (88.3, 93.6)
		Female	5.6 (4.4, 7.0)	94.4 (93.0, 95.6)	0.5 (0.1, 1.4)	10.2 (7.8, 13.3)	89.3 (86.4, 91.6)
	Mexican American	Male	5.3 (3.6, 7.6)	94.7 (92.4, 96.4)	0.9 (0.3, 2.4)	8.7 (6.2, 12.1)	90.4 (86.5, 93.3)
		Female	5.2 (3.9, 6.7)	94.8 (93.3, 96.1)	0.3 (0.1, 1.1)	9.8 (7.5, 12.7)	89.9 (87.0, 92.3)

Page last reviewed: October 21, 2008 (archived document)
Page last updated: October 21, 2008
Content Source: National Office of Public Health Genomics