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<title>Genomics|Population Research|U.S. Genome Variation Estimates|Frequencies

U.S. Genome Variation Estimates

CAT Allele and Genotype Frequencies
 Available polymorphism(s)
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rs number

Common Designations

           Nucleotide change                  Amino acid change

Genotyping method

rs769214

-843A>G 

 

TaqMan

 


 Allele and Genotype Frequencies for Subpopulations

 

BY RACE/ETHNICITY    [top]

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs769214 A G   AA AG GG    
  Non-Hispanic White 66.1 (63.4, 68.7) 33.9 (31.3, 36.6) <0.001 43.6 (40.0, 47.2) 45.0 (42.5, 47.6) 11.4 (9.4, 13.7) <0.001 0.68
  Non-Hispanic Black 58.8 (57.0, 60.6) 41.2 (39.4, 43.0) 35.0 (32.5, 37.6) 47.6 (44.8, 50.3) 17.4 (15.6, 19.4) 0.82
  Mexican American 49.7 (48.8, 50.6) 50.3 (49.4, 51.2) 24.0 (22.0, 26.1) 51.5 (47.4, 55.5) 24.6 (22.3, 27.0) 0.32
  Total* 62.4 (60.0, 64.7) 37.6 (35.3, 40.0)   39.5 (36.3, 42.7) 45.8 (43.4, 48.2) 14.8 (13.0, 16.7)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

 

BY AGE*  [top]

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs769214 A G   AA AG GG  
  12-19 63.4 (59.0, 67.5) 36.6 (32.5, 41.0) 0.498 39.5 (34.3, 44.9) 47.8 (43.7, 51.9) 12.7 (9.2, 17.2) 0.145
  20-39 61.0 (57.6, 64.3) 39.0 (35.7, 42.4) 38.4 (33.0, 44.2) 45.1 (39.9, 50.5) 16.4 (14.3, 18.8)
  40-59 62.6 (57.6, 67.3) 37.4 (32.7, 42.4) 39.1 (33.0, 45.6) 46.9 (42.3, 51.6) 14.0 (10.3, 18.7)
  >=60 64.0 (62.1, 65.9) 36.0 (34.1, 37.9) 42.0 (39.2, 44.9) 44.0 (41.5, 46.6) 14.0 (12.5, 15.6)
  Total 62.4 (60.0, 64.7) 37.6 (35.3, 40.0)   39.5 (36.3, 42.7) 45.8 (43.4, 48.2) 14.8 (13.0, 16.7)  

* Includes all participants, regardless of race/ethnicity.

 

BY SEX*  [top]

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs769214 A G   AA AG GG  
  Male 63.0 (59.2, 66.7) 37.0 (33.3, 40.8) 0.471 40.4 (35.5, 45.5) 45.2 (41.1, 49.4) 14.4 (11.3, 18.1) 0.747
  Female 61.8 (59.8, 63.6) 38.2 (36.4, 40.2) 38.6 (35.9, 41.4) 46.3 (43.7, 48.9) 15.1 (13.4, 16.9)
  Total 62.4 (60.0, 64.7) 37.6 (35.3, 40.0)   39.5 (36.3, 42.7) 45.8 (43.4, 48.2) 14.8 (13.0, 16.7)  

* Includes all participants, regardless of race/ethnicity.

 

BY RACE/ETHNICITY AND AGE    [top]

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs769214 A G AA AG GG
  Non-Hispanic White 12-19 67.9 (61.6, 73.5) 32.1 (26.5, 38.4) 44.8 (37.2, 52.7) 46.1 (40.8, 51.5) 9.1 (5.2, 15.4)
  20-39 65.8 (61.2, 70.2) 34.2 (29.8, 38.8) 43.8 (36.7, 51.2) 44.0 (37.5, 50.8) 12.2 (9.4, 15.6)
  40-59 65.0 (58.9, 70.7) 35.0 (29.3, 41.1) 41.6 (33.9, 49.7) 46.9 (41.1, 52.7) 11.6 (7.5, 17.3)
  >=60 67.1 (65.2, 68.8) 32.9 (31.2, 34.8) 45.2 (42.5, 47.9) 43.8 (41.1, 46.5) 11.1 (9.5, 12.8)
  Non-Hispanic Black 12-19 58.3 (55.7, 60.8) 41.7 (39.2, 44.3) 31.8 (27.1, 36.8) 53.0 (46.0, 59.8) 15.2 (11.9, 19.3)
  20-39 58.2 (55.4, 61.0) 41.8 (39.0, 44.6) 34.9 (31.9, 37.9) 46.7 (43.0, 50.5) 18.4 (15.0, 22.4)
  40-59 60.6 (56.8, 64.2) 39.4 (35.8, 43.2) 36.7 (31.6, 42.2) 47.7 (42.5, 52.9) 15.6 (12.2, 19.6)
  >=60 58.1 (52.9, 63.2) 41.9 (36.8, 47.1) 36.8 (30.1, 44.1) 42.6 (36.0, 49.6) 20.5 (15.8, 26.2)
  Mexican American 12-19 51.5 (48.0, 55.1) 48.5 (44.9, 52.0) 23.6 (17.6, 30.8) 55.9 (47.8, 63.7) 20.5 (17.1, 24.4)
  20-39 49.6 (47.5, 51.7) 50.4 (48.3, 52.5) 23.6 (20.0, 27.5) 52.1 (46.4, 57.7) 24.3 (21.2, 27.8)
  40-59 48.1 (43.8, 52.4) 51.9 (47.6, 56.2) 24.6 (19.5, 30.4) 47.0 (40.4, 53.8) 28.4 (23.2, 34.3)
  >=60 50.1 (45.6, 54.7) 49.9 (45.3, 54.4) 25.9 (19.8, 33.2) 48.3 (42.0, 54.7) 25.7 (21.9, 30.0)

 

 

BY RACE/ETHNICITY AND SEX    [top]

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs769214 A G AA AG GG
  Non-Hispanic White Male 66.8 (62.7, 70.8) 33.2 (29.2, 37.3) 44.3 (38.7, 50.1) 45.1 (40.1, 50.1) 10.6 (7.6, 14.8)
  Female 65.4 (63.1, 67.7) 34.6 (32.3, 36.9) 42.9 (39.5, 46.4) 45.0 (42.1, 47.9) 12.1 (10.4, 14.0)
  Non-Hispanic Black Male 60.3 (56.9, 63.7) 39.7 (36.3, 43.1) 38.0 (33.8, 42.4) 44.7 (41.4, 48.0) 17.4 (14.4, 20.7)
  Female 57.6 (55.2, 59.9) 42.4 (40.1, 44.8) 32.6 (29.9, 35.4) 50.0 (47.0, 53.0) 17.4 (14.8, 20.5)
  Mexican American Male 49.5 (47.8, 51.2) 50.5 (48.8, 52.2) 24.5 (22.9, 26.2) 50.0 (47.0, 53.0) 25.5 (22.9, 28.3)
  Female 49.9 (48.1, 51.7) 50.1 (48.3, 51.9) 23.4 (19.6, 27.7) 53.0 (46.9, 59.1) 23.6 (20.7, 26.6)
Page last reviewed: October 21, 2008 (archived document)
Page last updated: October 21, 2008
Content Source: National Office of Public Health Genomics