The Office of Adolescent Health partners with many federal agencies on adolescent health initiatives. The following federal agencies or offices handle various issues related to adolescent health and well-being.

• Administration for Children and Families
• Administration for Children and Families-Administration for Native Americans
• Administration for Children and Families- Family Youth Services Bureau
• Agency for Healthcare Research and Quality-Office of Extramural Research, Education and Priority Populations
• Center for Faith-Based and Neighborhood Partnerships
• Centers for Disease Control and Prevention-Division of Adolescent and School Health
• Centers for Disease Control – Division of Reproductive Health
• Centers for Disease Control and Prevention-National Center for Health Statistics
• Centers for Disease Control and Prevention-National Center for Immunization and
• Respiratory Diseases, Office of Health Communication Science
• Centers for Medicare and Medicaid Services
• Food and Drug Administration-Office of Pediatric Therapeutics
• Health Resources and Services Administration- Maternal and Child Health Bureau
• Health Resources and Services Administration-Bullying Prevention Campaign
• Office of Disease Prevention and Health Promotion, HHS
• Office of HIV/AIDS Policy, HHS
• Office of Minority Health, HHS
• Office of Population Affairs, HHS
• Office of the Assistant Secretary for Financial Resources, HHS
• Office of the Assistant Secretary for Planning and Evaluation-Division of Children and Youth Policy, HHS
• Office on Disability, HHS
• Office on Women's Health, HHS
• Indian Health Service-Division of Behavioral Health
• National Institutes of Health-National Institute of Child Health and Human Development, Division of Special Populations
• National Institutes of Health-National Institute of Drug Abuse, Prevention Research Branch
• National Institutes of Health-National Institute of Mental Health, Division of Developmental and Translational Research
• Office of the Assistant Secretary for Health, HHS
• President's Council on Physical Fitness and Sports
• Keeping Youth Drug Free
• Substance Abuse and Mental Health Services Administration-Office of the Administrator
• Substance Abuse and Mental Health Services Administration-Too Smart to Start (SAMHSA underage drinking initiative)
• Regional Health Administrators
• United States Department of Agriculture-National 4-H Headquarters, Youth Development Research
• United States Department of Agriculture-National Children, Youth, and Families Risk Coordinator
• United States Department of Education