Ivanov, A.A., Barak, D., Jacobson, K.A. Evaluation of homology modeling of G protein-coupled receptors in light of the A2A adenosine receptor crystallographic structure. J. Med. Chem., 2009, doi: 10.1021/jm801533x. [Full Text/Abstract]
Ivanov, A.A., Jacobson, K.A. Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer. Bioorg. Med. Chem. Lett., 2008, 18:4312-4315 [Full Text/Abstract]
Klutz, A.M., Gao, Z.G., Lloyd, J., Shainberg, A., Jacobson, K.A. Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates. J. Nanobiotechnol., 2008, 6:12. [Full Text/Abstract]
Kim, Y., Klutz, A.M., Jacobson, K.A. Systematic investigation of polyamidoamine dendrimers surface-modified with poly(ethylene glycol) for drug delivery applications: Synthesis, characterization, and evaluation of cytotoxicity. Bioconjugate Chem., 2008, 19:1660-1672. [Full Text/Abstract]
Ko, H., Fricks, I., Ivanov, A.A., Harden, T.K., Jacobson, K.A. Structure activity relationship of uridine 5¢-diphosphoglucose (UDP-glucose) analogues as agonists of the human P2Y14 receptor. J. Med. Chem., 2007, 50:2030-2039. [Full Text/Abstract]
Jacobson, K.A., Gao, Z.G., Liang, B.T. Neoceptors: Reengineering GPCRs to recognize tailored ligands. Trends Pharmacol. Sci., 2007, 28:111-116. [Full Text/Abstract]
Jacobson, K.A., Gao, Z.G. Adenosine receptors as therapeutic targets. Nature Rev. Drug Disc., 2006, 5:247-264. [Full Text/Abstract]
Gao, Z.G., Jacobson, K.A. Allosterism in membrane receptors. Drug Disc. Today, 2006, 11:191-202. [Full Text/Abstract]
Gao ZG, Jacobson KA Emerging adenosine receptor agonists. Expert Opin Emerg Drugs(12): 479-92, 2007. [Full Text/Abstract]
Jacobson KA, Gao ZG, Liang BT Neoceptors: reengineering GPCRs to recognize tailored ligands. Trends Pharmacol Sci(28): 111-6, 2007. [Full Text/Abstract]
Ko H, Fricks I, Ivanov AA, Harden TK, Jacobson KA Structure-activity relationship of uridine 5''-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J Med Chem(50): 2030-9, 2007. [Full Text/Abstract]
Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, Joshi BV, Jacobson KA, Kohsaka S, Inoue K UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature(446): 1091-5, 2007. [Full Text/Abstract]
Jacobson KA, Gao ZG Adenosine receptors as therapeutic targets. Nat Rev Drug Discov (5): 247-64, 2006. [Full Text/Abstract]
Jacobson KA, Ohno M, Duong HT, Kim SK, Tchilibon S, C esnek M, Holy A, Gao ZG A Neoceptor Approach to Unraveling Microscopic Interactions between the Human A(2A) Adenosine Receptor and Its Agonists. Chem Biol (12): 237-247, 2005. [Full Text/Abstract]
Joshi BV, Moon HR, Fettinger JC, Marquez VE, Jacobson KA A New Synthetic Route to (North)-Methanocarba Nucleosides Designed as A(3) Adenosine Receptor Agonists. J Org Chem (70): 439-447, 2005. [Full Text/Abstract]
Gao ZG, Kim SK, Ijzerman AP, Jacobson KA Allosteric modulation of the adenosine family of receptors. Mini Rev Med Chem (5): 545-53, 2005. [Full Text/Abstract]
Kim HS Ohno M Xu B Kim HO Choi Y Ji XD Maddileti S Marquez VE Harden TK Jacobson KA 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. J Med Chem (46): 4974-87, 2003. [Full Text/Abstract]
Jacobson KA Jarvis MF Williams M Purine and pyrimidine (P2) receptors as drug targets. J Med Chem (45): 4057-93, 2002. [Full Text/Abstract]