BackgroundHead and neck cancer including oral cancer is considered to develop by accumulated genetic alterations and the major pathway is cancerization from lesions such as intraepithelial dysplasia in oral leukoplakia and erythroplakia. The relationship of proliferation markers with the grading of dysplasia is uncertain. The involvement of EBV in oral carcinogenesis is not fully understood.AimThe ...

Salvicine is a novel diterpenoid quinone compound obtained by structural modification of a natural product lead isolated from a Chinese herb with potent growth inhibitory activity against a wide spectrum of human tumor cells in vitro and in mice bearing human tumor xenografts. Salvicine has also been found to have a profound cytotoxic effect on multidrug-resisitant (MDR) cells. Moreover, Salvicine ...

Topoisomerase II? (topo II?) is exported from the nucleus of human myeloma cells by a CRM1-dependent mechanism at cellular densities similar to those found in patient bone marrow. When topo II? is trafficked to the cytoplasm, it is not in contact with the DNA; thus topo II? inhibitors are unable to induce ...

As a result of the recurring translocation t(11;16) (q23;p13.3), MLL (mixed-lineage leukemia) is fused in frame to CBP (CREB binding protein). This translocation has been documented almost exclusively in cases of acute leukemia or myelodysplasia secondary to therapy with drugs that target DNA topo isomerase�II. The minimal chimeric ...

Etoposide (VP-16), a topoisomerase II (Topo II) inhibitor, has been widely used to treat malignancies. Its clinical application, however, has been hindered by the rise of acquired multidrug resistance (MDR). Here, we report that 4?-{[4-(pyrrolidin-1-ylmethyl)phenyl]amino}-4'-O-Demethyl-4-Epipodophyllotoxin (5k), a novel ?-O-demethyl-epipodophyllotoxin ...

Topoisomerase IV (Topo IV), an essential ATP-dependent bacterial type II topoisomerase, transports one segment of DNA through a transient double-strand break in a second segment of DNA. In vivo, Topo IV unlinks catenated chromosomes before cell division and relaxes positive supercoils generated during DNA replication. In vitro, Topo IV relaxes positive supercoils at least ...

Riccardin D is a novel macrocyclic bisbibenzyl compound extracted from Chinese liverwort plant Dumortiera hirsuta. Our previous studies showed that riccardin D is a DNA topo II inhibitor and has therapeutic potential for treatment of cancers. In this combined in vitro and in vivo study, we examined the inhibitory effects of riccardin D ...

... samples of single crystalline and polycrystalline alpha-alumina have been neutron-irradiated in the Experimental Breeder Reactor-II (EBR-II) to ...

Radiative transfer of Ly-alpha, Ly-beta, and H-alpha in a hydrogen gas containing dust is considered

... Title : LYMAN ALPHA RADIATION IN THE NIGHT-TIME MESOPAUSE AND LOWER THERMOSPHERE-II, IN: JOURNAL OF ATMOSPHERIC AND ...

An eruptive prominence and coronal transient was observed in H-alpha, He II 304-A, and coronal white

A phenomenological analysis of the energetics of the beta-to-alpha transformation in polycrystalline

Blue Dashed Line on Flow Diagram. Alpha Magnetic Spectrometer 02. Ground Operations ..... Hurricane Plan. Power down safe without services. ...

... Abstract : A frost-point hygrometer for use on W-47 aircraft has been designed utilizing alpha radiation techniques to measure the condensate ...

Purpose: Topoisomerase II{alpha} (Topo II{alpha}) plays a role in DNA replication and is the molecular target for anthracyline-based chemotherapy. The purpose of this study was to evaluate the relationship between Topo II{alpha} expression and survival in patients with invasive breast cancer. Methods and Materials: Formalin-fixed, ...

The research described in the thesis concerns the study of the formation, stabilization and reactivity of homo- and heteronuclear metal carbonyl alpha-diimine complexes containing metal-metal bonds. In Chapters I and II the reactions of alpha-diimines wit...

Results are presented from studies of the inclusive photon spectra in hadronic decays of the UPSILON' and UPSILON and the exclusive channel UPSILON' implies gamma gamma UPSILON implies alpha alpha l exp + l exp - , by the Crystal Ball detector at DORIS II...

Immunohistochemical cell proliferation analyses have come into wide use for evaluation of tumor malignancy. Topoisomerase II{alpha} (topo II{alpha}), an essential nuclear enzyme, has been known to have cell cycle coupled expression. We here show the usefulness of quantitative analysis of topo II{alpha} mRNA to rapidly evaluate cell ...

... TITLE: Phase I/II Trial of 13-Cis Retinoic Acid, Alpha Interferon, Taxotere, and Estramustine (RITE) for the Treatment of Hormone Refractory Prostate ...

... I/II Trial of 13-Cis Retinoic Acid, Alpha Interferon, Taxotere, and Estramustine (RITE) for the Treatment of Hormone Refractory Prostate Cancer. ...

... BAXJECT II Hi-Flow device packaged with ARALAST NP [Alpha1-Proteinase Inhibitor (Human)]. DATE CORRECTION INITIATED: May 9, 2011. ...

... Title : Unusual Magnetic Properties in Two Copper(II) Chelates of Schiff Bases Derived from Alpha-Amino Acids: A Dimeric Interaction in a ...

The solar O III spectrum above 900 A is analyzed, including several visible and infrared lines which

CAMK2A, also known as A0011, is the alpha subunit of the calcium/calmodulin-dependent protein kinase II (CaM kinase II).

... Title : ALUMINUM-LITHIUM ALLOYS II; THE EFFECT OF TERNARY ADDITIONS ON THE DELTA/ALPHA MISFIT AND THE DELTA SOLVUS LINE ...

The organization of the alpha-globin genes was studied by restriction endonuclease mapping, in subjects carrying the alpha variant Hb J Mexico. A subject homozygous for Hb J synthesized both Hb J (about 55%) and Hb A and had two alpha loci per chromosome. His restriction site map was found to be identical to that obtained with a normal ...

Ion-pair return from the ion-pair intermediate(s) common to trans-alpha-phenyl-gamma-methylallyl and trans-alpha-methyl-gamma-phenylallyl p-nitrobenzoates (I and II) gives the gamma-phenylallylisomer (II). In aqueous acetone the alpha-phenylallyl isomer (...

Autocorrelation and cross-correlation functions as well as power spectra are derived for 20 photometric scans of concurrent H..cap alpha.. and Ca II K interference-filter photographs of the solar chromosphere. The chromospheric network cells in the two lines differ, with the cell diameter in H..cap alpha.. approximately half that in Ca ...

... II. ... and photolytic decomposition of the lithium salts reveals ... Descriptors : *Carbenes, *Hydrazones, *Chemical reactions, Unsaturated hydrocarbons ...

>Acid dissociation constants of some BETA -keto esters, viz. ethyl acetoacetate, ethyl alpha -phenyl acetoacetate, ethyl alpha - gamma -diphenyl acetoacetate, ethyl alpha -phenyl)phenylpropioloylacetate, ethyl alpha ( alpha -naphthyl)phenylpropioloylacetate, have been ...

Resistance to anticancer drugs that target DNA topoisomerase II (topo II) isoforms {alpha} and/or {beta} is associated with decreased nuclear and increased cytoplasmic topo II{alpha}. Earlier studies have confirmed that functional nuclear localization and export signal sequences (NLS and NES) are present in both ...

The pure evaporation model program was run for the $sup 27$Al($alpha$, 2$alpha$) and $sup 27$Al($alpha$, 3$alpha$) reactions to determine the yield. Limitations of the program are discussed. (BJG)

The turkey sperm glycocalyx is known to contain residues of sialic acid, alpha-mannose/alpha-glucose, alpha- and beta-galactose, alpha-fucose, alpha- and beta-N-acetyl-galactosamine, monomers and dimers of N-acetyl-glucosamine and N-acetyl-lactosamine. Potential changes in these carbohydrates during...

The drug-binding properties of human alpha-foetoprotein (alpha FP) were investigated by a fluorescence-spectral method. Human alpha FP was shown to bind to albumin's site I marker (warfarin, phenylbutazone), site II marker (L-tryptophan), but not site III marker (cholic acid, digoxin). The binding of human ...

The adsorption of NO on Co(II)-exchanged chabazite (CHA), mordenite (MOR), and ferrierite (FER) has been investigated by periodic density functional theory calculations. The most stable configurations of Co(II) in alpha and beta sites of the zeolites with two framework Al/Si substitutions at short distances and Al-(Si)(n>1)-Al ...

Hemoglobin A (HbA), the oxygen delivery system in humans, comprises two alpha and two beta subunits. Free alpha-hemoglobin (alphaHb) is unstable, and its precipitation contributes to the pathophysiology of beta thalassemia. In erythrocytes, the alpha-hemoglobin stabilizing protein (AHSP) binds ...

We have examined trafficking of major histocompatibility complex (MHC) class II molecules in human B cells exposed to concanamycin B, a highly specific inhibitor of the vacuolar H(+)-ATPases required for acidification of the vacuolar system and for early to late endosomal transport. Neutralization of vacuolar compartments prevents breakdown of the invariant chain ...

Australian aborigines exhibit a number of alpha-globin cluster rearrangements involving both alpha- and zeta-globin genes. alpha+-Thalassemia (-alpha/) in this population is heterogeneous and includes the 3.7 types I, II, and III gene deletions. The alpha ...

The existence of two forms of the chicken estrogen receptor-alpha protein (ER-alpha) in chicken tissues is demonstrated: the previously reported receptor (cER-alpha form I), which has a size of 66 kDa, and a new form (cER-alpha form II), which lacks the N-terminal 41 amino acids present in form ...

A study of H alpha , STAN II!, and STAO III! line profiles was made in M8 and M20 using a Fabry-- Perot interferometer. Temperatures were estimated from both the relatlve widths and the relative intensities of H alpha and STAN II!. The two methods often showed large discrepancies. After removal of thermal ...

We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice. The Zn(II) complex showed strong alpha-glucosidase inhibitory ...

Golgi alpha-mannosidase II is essential for the efficient formation of complex-type glycosylation. Here, we demonstrate that the disruption of Golgi alpha-mannosidase II activity by swainsonine in human embryonic kidney cells is capable of inducing a novel class of hybrid-type glycosylation containing a partially ...

Invariant chain (Ii) is a nonpolymorphic, non-major histocompatibility complex (MHC)-encoded glycoprotein that rapidly associates with newly synthesized class II MHC alpha and beta chains in the rough endoplasmic reticulum. This oligomerization of Ii, alpha, and beta and their cotransport ...

We investigated whether transforming growth factor-alpha (TGF-alpha) regulates mouse placental lactogen-II (mPL-II) secretion by cells from day 12 of pregnancy. TGF-alpha significantly inhibited mPL-II secretion by the third and fourth day of culture, and then stimulated ...

Golgi alpha-mannosidase II (alpha-MII) is an enzyme involved in the processing of N-linked glycans. Using a previously isolated murine cDNA clone as a probe, we have isolated cDNA clones encompassing the human alpha-MII cDNA open reading frame and initiated isolation of human genomic clones. During the isolation of ...

Dihydrotestosterone (DHT) is the most potent male hormone that causes androgenetic alopecia. The type II 5alpha-reductase is an enzyme that catalyzes the conversion of testosterone (T) to DHT, therefore it can be expected that specific inhibitors for type II 5alpha-reductase may improve the pathophysiologic status ...

Four B stars, ..cap alpha.. Vir, ..beta.. Cen, ..cap alpha.. Gru, and ..beta.. Lib, were observed with the Copernicus Princeton Telescope Spectrometer at a resolution of 0.1 A in order to investigate the presence of chromospheric emission. Emission was observed in ..beta.. Cen and ..cap alpha.. Gru, while the results for ..cap ...

For alpha sources there is often the problem of determining, sometimes simultaneously, both the source activity and the spectral distribution of the alpha emitted. In the Laboratory for the Measurement of Artificial Radioelements ionization chambers are generally utilized. The characteristics of several types of ionization chambers are given, ...

alpha-Cyano-alpha-ferrocenylethoxytrimethylsilame was prepared by the addition of trimethysilyl cyanide to acetylferrocene. 2-Hydroxy-2-ferrocenylpropylamine(FcA) was synthesized by the reduction of alpha-cyano-alpha-ferrocenylethoxytrimethylsilame with lithium aluminum hydride. A series of coordinate complexes--FcA-Ni(II), ...