2006 National DNA Day Online Chatroom Transcript
This is just one question from an archive of the National DNA Day Moderated Chat held in April 2006. The NHGRI Director and many genomics experts from across NHGRI took questions from students, teachers and the general public on topics ranging from basic genomic research, to the genetic basis of disease, to ethical questions about genetic privacy.
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How do introns get spliced out from mRNA? How does the body detect whether a segment of mRNA is an intron or exon?
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Jennifer Pitrak, Ph.D.: This is a great question!
Introns get spliced out of pre-mRNAs by enyzmes in the cell nucleus. Introns are recognized by these enzymes because of specific sequences in the mRNA that delineate the intron (intron-specific sequences).
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