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U.S. Department of Health and Human Services

Drugs

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Cytochrome P450 3A

  • Responsible for metabolism of:
    • Most calcium channel blockers
    • Most benzodiazepines
    • Most HIV protease inhibitors
    • Most HMG-CoA-reductase inhibitors
    • Cyclosporine
    • Most non-sedating antihistamines
    • Cisapride
  • Present in GI tract and liver

 

 

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