Gain Analysis Workshop II
Agenda and Presentations
October 17-18, 2007
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Wednesday, October 17, 2007
7:00 - 8:30 a.m. |
Continental Breakfast and Registration |
Lecture Resources |
8:30 - 8:45 a.m. |
Welcome: Introduction and Agenda |
Francis Collins |
8:45 - 9:15 a.m. |
Overview: Status of GAIN
- Data available, presentation/publication plans
- GAIN 2.0
- Mental health disorders collaboration
|
Teri Manolio David Wholley Patrick Sullivan |
9:15 - 10:30 a.m. |
GAIN Genotyping
- Broad genotyping center update
- Review of genotyping QA pipeline
- QA process and results to date
|
Stacey Gabriel
Finny Kuruvilla
Justin Paschall |
10:30 a.m. |
Discussion |
|
10:45 - 11:15 a.m. |
Break |
|
11:15 - 11:45 a.m. |
GAIN Genotyping (continued)
- Groups whose genotypes are completed describe their experience with working through
QC issues
|
Ben Neale
James Warram
Patrick Sullivan |
11:45 a.m. - Noon |
GAIN Datasets
- Updating and versioning data releases beyond the initial one
|
James Ostell |
12:00 - 12:30 p.m. |
Discussion |
|
12:30 - 1:30 p.m. |
Lunch |
|
|
Afternoon Session |
|
1:30 - 2:30 p.m. |
Imputation
- IMPUTE Method
- MACH Method
- TUNA Method
- GAIN progress to date
|
Jonathan Marchini
Gonçalo Abecasis Dan Nicolae Itsik Pe'er |
2:30 - 3:00 p.m. |
Bayes Factors
- Meaning and use
- Comparison to p-values in GAIN
|
Jonathan Marchini |
3:00 - 3:30 p.m. |
Discussion |
|
3:30 - 4:00 p.m. |
Break |
|
4:00 - 5:00 p.m. |
Assessing and analyzing copy number variants in GAIN platforms |
Steve McCarroll |
5:00 - 5:45 p.m. |
Analysis of and adjustment for population structure |
Paul de Bakker
Gilles Thomas |
5:45 - 6:00 p.m. |
Discussion |
|
6:00 p.m. |
Adjorn |
|
6:30 p.m. |
Reception |
|
|
Thursday, October 18, 2007
7:00 - 8:00 a.m. |
Continental Breakfast |
|
8:00 - 9:00 a.m. |
GAIN Data Access Experience and Ongoing Issues
- Brief review of access process, status of distribution, use
- GAIN human subjects protections: view from external review committees/IOM panel
- NIH GWAS Policy
|
Emily Harris
Wylie Burke
Laura RodrÃguez |
9:00 - 9:15 a.m. |
Discussion |
|
9:15 - 10:00 a.m. |
WTCCC Bipolar Disorder
- Genotype QC filtering
- Population structure
- Initial GWA findings, replication
- Cross-study analyses
- Follow-up of initial findings
|
Nick Craddock |
10:00 - 10:15 a.m. |
Break |
|
10:15 - 11:00 a.m. |
FUSION Type II Diabetes
- Genotype QC filtering
- Population structure
- Initial GWA findings, replication
- Cross-study analyses, including CAD and obesity
- Follow-up of initial findings
|
Mike Boehnke |
11:00 - 11:45 a.m. |
Prostate Cancer
- Genotype QC filtering
- Population structure
- Initial GWA findings, replication
- Cross-study analyses, including breast and colon cancer
- Follow-up of initial findings
|
Matthew Freedman |
11:45 a.m. - 12:30 p.m. |
Breast Cancer
- Genotype QC filtering
- Population structure
- Initial GWA findings, replication
- Cross-study analyses
- Follow-up of initial findings
|
Steve Chanock |
12:30 - 1:30 p.m. |
Lunch |
|
1:30 - 2:15 p.m. |
Crohn's Disease
- Genotype QC filtering
- Population structure
- Initial GWA findings, replication
- Cross-study analyses
- Follow-up of initial findings
|
Dan Nicolae |
2:15 - 3:00 p.m |
Panel discussion (all five speakers) |
Moderator: Francis Collins |
3:00 - 3:30 p.m. |
Conclusion and next steps |
John Kelsoe
Teri Manolio |
3:00 - 3:30 p.m. |
Adjournment |
Francis Collins |
|
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Last Updated: November 21, 2010