Association of the number of risk alleles in sentinel SNPs with type 2 diabetes (A), percent body fat (B), insulin sensitivity (C), and AIR (D). Sentinel SNPs are defined as SNPs in CDKAL1 (rs7756992), SLC30A8 (rs13266634), HHEX (rs1111875), IGF2BP2 (rs4402960), CDKN2B (rs10811661), FTO (rs8050136), and TCF7L2 (rs7903146). Risk alleles are defined from studies in Caucasians (see Table 1). Numbers of individuals in each of the allelic groups (≤3, 4, 5, 6, 7, 8, and ≥9) are 55, 295, 668, 795, 524, 329, and 77, respectively, for type 2 diabetes; 9, 43, 82, 85, 49, 21, and 11 for percent body fat and insulin sensitivity; and 5, 32, 60, 59, 35, 14, and 8 for insulin secretion.