(A) Hazard ratio of ESRD, adjusted for age, gender, and duration of diabetes and categorized by albuminuria and estimated GFR (eGFR) in Pima Indians with type 2 diabetes mellitus (T2DM). [n=2420, 287 of whom developed diabetic ESRD] Individuals with normoalbuminuria and eGFR 90 to 119 ml/min per 1.73 m2 were the referent group m. The hazard ratios (95% confidence intervals) compared with the referent group are 1.2 (0.8 to 2.0) for normoalbuminuria and eGFR ≥ 120 ml/min per 1.73 m2, 1.5 (0.6 to 4.0) for normoalbuminuria and eGFR 60 to 89 ml/min per 1.73 m2, 5.7 (0.8 to 42.1) for normoalbuminuria and eGFR 30 to 59 ml/min per 1.73 m2, 1.3 (0.7 to 2.4) for microalbuminuria and eGFR ≥ 120 ml/min per 1.73 m2, 3.1 (2.0 to 4.8) for microalbuminuria and eGFR 90 to 119 ml/min per 1.73 m2, 6.0 (3.0 to 11.0) for microalbuminuria and eGFR 60 to 89 ml/min per 1.73 m2, 3.8 (0.5 to 28.1) for microalbuminuria and eGFR 30 to 59 ml/min per 1.73 m2, 6.9 (3.6 to 13.1) for macroalbuminuria and eGFR ≥ 120 ml/min per 1.73 m2, 8.7 (5.6 to 13.6) for macroalbuminuria and eGFR 90 to 119 ml/min per 1.73 m2, 14.6 (8.7 to 24.4) for macroalbuminuria and eGFR 60 to 89 ml/min per 1.73 m2, 56.6 (31.8 to 100.7) for macroalbuminuria and eGFR 30 to 59 ml/min per 1.73 m2, and 290.9 (130.0 to 650.8) for macroalbuminuria and eGFR 15 to 29 ml/min per 1.73 m2. (B) Cumulative incidence of ESRD at 10-year follow-up for categories of albuminuria and eGFR. Cumulative incidence is calculated from the proportional hazards model and the baseline hazard rate, adjusted for age, gender, and duration of diabetes. (C) Hazard ratio of mortality adjusted for age, gender, and duration of diabetes and categorized by albuminuria and eGFR in Pima Indians with T2DM [n=2420, 570 of whom died during follow-up]. Individuals with normoalbuminuria and eGFR 90 to 119 ml/min per 1.73 m2 were the referent group m. The hazard ratios (95% confidence intervals) compared with the referent group are 1.2 (0.9 to 1.7) for normoalbuminuria and eGFR ≥ 120 ml/min per 1.73 m2, 1.6 (1.1 to 2.3) for normoalbuminuria and eGFR 60 to 89 ml/min per 1.73 m2, 2.3 (0.8 to 6.1) for normoalbuminuria and eGFR 30 to 59 ml/min per 1.73 m2, 1.0 (0.6 to 1.7) for microalbuminuria and eGFR ≥ 120 ml/min per 1.73 m2, 1.5 (1.1 to 1.9) for microalbuminuria and eGFR 90 to 119 ml/min per 1.73 m2, 2.0 (1.3 to 3.0) for microalbuminuria and eGFR 60 to 89 ml/min per 1.73 m2, 4.3 (2.1 to 8.9) for microalbuminuria and eGFR 30 to 59 ml/min per 1.73 m2, 2.9 (1.7 to 5.1) for macroalbuminuria and eGFR ≥ 120 ml/min per 1.73 m2, 2.0 (1.4 to 2.7) for macroalbuminuria and eGFR 90 to 119 ml/min per 1.73 m2, 2.5 (1.8 to 3.6) for macroalbuminuria and eGFR 60 to 89 ml/min per 1.73 m2, 6.5 (4.4 to 9.8) for macroalbuminuria and eGFR 30 to 59 ml/min per 1.73 m2, and 7.5 (4.2 to 13.5) for macroalbuminuria and eGFR 15 to 29 ml/min per 1.73 m2. (D) Cumulative mortality at 10-year follow-up for categories of albuminuria and eGFR. Cumulative mortality is calculated from the proportional hazards model and the baseline hazard rate, adjusted for age, gender, and duration of diabetes.