Jak-2 mRNA expression levels in human diabetic nephropathy: correlation with renal function.
A: Increased expression of Jak-2 mRNA in the glomeruli of early diabetic nephropathy patients and in the tubulointerstitium of progressive diabetic nephropathy patients compared with control subjects (
n = 6–9 in the control group,
n = 11–12 in the early diabetic nephropathy group, and
n = 10–12 in the progressive diabetic nephropathy group). □, control;
, early diabetic nephropathy; ▪, progressive diabetic nephropathy.
B: Correlation of tubulointerstitial Jak-2 mRNA expression (as measured by real-time RT-PCR) with eGFR in patients with early (×,
n = 11) and progressive (•,
n = 12) diabetic nephropathy.
C: Representative Jak-2 immunohistographs of kidney biopsies from patients with no kidney disease (Control), progressive diabetic nephropathy (Prog. DN), hypertensive nephropathy (HTN), IgA nephropathy (IgAN), or lupus nephritis (LN). Jak-2 expression was substantially and significantly increased in the proximal tubular cells and glomeruli of the patients with diabetic nephropathy compared with the control and not in other progressive kidney diseases. (Please see http://dx.doi.org/10.2337/db08-1328 for a high-quality digital representation of this figure.)