Principal Officers and Chiefs of Mission, by year: 1860
Note: Career Foreign Service appointees are asterisked.
- Wright, Joseph Albert (1810-1867)
- Envoy Extraordinary and Minister Plenipotentiary, Germany (1857-1861)
- Envoy Extraordinary and Minister Plenipotentiary, Germany (1865-1867)
- Williams, James (1796-1869)
- Minister Resident, Turkey (1858-1861)
- Angel, Benjamin Franklin (1815-1894)
- Minister Resident, Sweden (1857-1861)
- Appleton, John (1815-1864)
- Chief Clerk (1848)
- Chargé d'Affaires, Bolivia (1848-1849)
- Assistant Secretary of State (1857-1860)
- Envoy Extraordinary and Minister Plenipotentiary, Russia (1860-1861)
- Bigler, John (1805-1871)
- Envoy Extraordinary and Minister Plenipotentiary, Chile (1857-1861)
- Black, Jeremiah Sullivan (1810-1883)
- Secretary of State (1860-1861)
- Borden, James Wallace (1810-?)
- Commissioner, Hawaii (1858-1861)
- Clarke, Beverly Leonidas (1809-1860)
- Minister Resident, Guatemala (1858-1860)
- Minister Resident, Honduras (1858-1860)
- Buchanan, James M. (1803-1876)
- Minister Resident, Denmark (1858-1861)
- Buckalew, Charles Rollin (1821-1899)
- Minister Resident, Ecuador (1858-1861)
- Cass, Lewis (1782-1866)
- Envoy Extraordinary and Minister Plenipotentiary, France (1836-1842)
- Secretary of State (1857-1860)
- Cushman, John Franklin (?-1862)
- Minister Resident, Argentina (1859-1861)
- Dallas, George Mifflin (1792-1864)
- Envoy Extraordinary and Minister Plenipotentiary, Russia (1837-1839)
- Envoy Extraordinary and Minister Plenipotentiary, United Kingdom (1856-1861)
- De Leon, Edwin (1818-1891)
- Agent/Consul General, Egypt (1853-1861)
- Dimitry, Alexander (1805-1883)
- Minister Resident, Costa Rica (1859-1861)
- Minister Resident, Nicaragua (1859-1861)
- Ellsworth, Henry William (1814-1864)
- Chargé d'Affaires, Sweden (1845-1861)
- Fair, Elisha Young (1809-1886)
- Minister Resident, Belgium (1858-1861)
- Faulkner, Charles James (1806-1884)
- Envoy Extraordinary and Minister Plenipotentiary, France (1860-1861)
- Fay, Theodore Sedgwick (1807-1898)
- Ambassador Extraordinary and Plenipotentiary, Switzerland (1853-1861)
- Harris, Townsend (1804-1878)
- Minister Resident, Japan (1859-1862)
- Jones, George Wallace (1804-1896)
- Minister Resident, Colombia (1859-1861)
- Jones, Jehu Glancy (1811-1878)
- Minister Resident, Austria (1858)
- Envoy Extraordinary and Minister Plenipotentiary, Austria (1858-1861)
- Hunter, William (1805-1886)
- Chief Clerk (1852-1855)
- Secretary of State ad interim (1853)
- Assistant Secretary of State (1855)
- Secretary of State ad interim (1860)
- Second Assistant Secretary of State (1866-1886)
- McLane, Robert Milligan (1815-1898)
- Commissioner, China (1853-1854)
- Envoy Extraordinary and Minister Plenipotentiary, Mexico (1859-1860)
- Envoy Extraordinary and Minister Plenipotentiary, France (1885-1889)
- Meade, Richard Kidder (1803-1862)
- Chargé d'Affaires, Italy (1853)
- Envoy Extraordinary and Minister Plenipotentiary, Brazil (1857-1861)
- Morgan, George Washington (1820-1893)
- Minister Resident, Portugal (1858-1861)
- Murphy, Henry Cruse (1810-1882)
- Minister Resident, Netherlands (1857-1861)
- Pickens, Francis Wilkinson (1805-1869)
- Envoy Extraordinary and Minister Plenipotentiary, Russia (1858-1860)
- Preston, William (1861-1887)
- Envoy Extraordinary and Minister Plenipotentiary, Spain (1858-1861)
- Smith, John Cotton (1810-1879)
- Minister Resident, Bolivia (1858-1861)
- Stockton, John Potter (1826-1900)
- Minister Resident, Holy See (1858-1861)
- Envoy Extraordinary and Minister Plenipotentiary, Austria (Not commissioned; nomination rejected by the Senate.)
- Trescot, William Henry (1822-1898)
- Assistant Secretary of State (1860)
- Turpin, Edward A. (?-?)
- Minister Resident, Venezuela (1858-1861)
- Ward, John Elliott (1814-1902)
- Envoy Extraordinary and Minister Plenipotentiary, China (1858-1860)
- Weller, John B. (1812-1875)
- Envoy Extraordinary and Minister Plenipotentiary, Mexico (1860-1861)