Principal Officers and Chiefs of Mission, by year: 1845
Note: Career Foreign Service appointees are asterisked.
- Wise, Henry Alexander (1806-1876)
- Envoy Extraordinary and Minister Plenipotentiary, Brazil (1844-1847)
- Envoy Extraordinary and Minister Plenipotentiary, France (Not commissioned; nomination rejected by the Senate.)
- Bidlack, Benjamin A. (1804-1849)
- Chargé d'Affaires, Colombia (1845-1849)
- Boulware, William (?-?)
- Chargé d'Affaires, Two Sicilies (1841-1845)
- Clemson, Thomas Green (1807-1888)
- Chargé d'Affaires, Belgium (1844-1851)
- Brent, William (1783-1848)
- Chargé d'Affaires, Argentina (1844-1846)
- Bryan, John Alexander (?-?)
- Chargé d'Affaires, Peru (1844-1845)
- Buchanan, James (1791-1868)
- Envoy Extraordinary and Minister Plenipotentiary, Russia (1832-1833)
- Secretary of State (1845-1849)
- Envoy Extraordinary and Minister Plenipotentiary, United Kingdom (1853-1856)
- Calhoun, John Caldwell (1782-1850)
- Secretary of State (1844-1845)
- Carr, Dabney Smith (1802-1854)
- Minister Resident, Turkey (1843-1849)
- Crump, William Wood (1819-1897)
- Chargé d'Affaires, Chile (1844-1847)
- Davezac (D'Avezac), Auguste Genevieve Valentin (1780-1851)
- Chargé d'Affaires, Netherlands (1831-1839)
- Chargé d'Affaires, Netherlands (1845-1850)
- Cralle, Richard K. (?-?)
- Donelson, Andrew Jackson (1799-1871)
- Chargé d'Affaires, Texas (1844-1845)
- Envoy Extraordinary and Minister Plenipotentiary, Germany (1846-1849)
- Envoy Extraordinary and Minister Plenipotentiary, Germany (1848-1849)
- Derrick, William S. (?-1852)
- Secretary of State ad interim (1843)
- Chief Clerk (1843-1844)
- Chief Clerk (1845)
- Chief Clerk (1847-1848)
- Chief Clerk (1848-1852)
- Ellis, Vespasian (?-?)
- Chargé d'Affaires, Venezuela (1844-1845)
- Ellsworth, Henry William (1814-1864)
- Chargé d'Affaires, Sweden (1845-1861)
- Everett, Alexander Hill (1790-1847)
- Chargé d'Affaires, Netherlands (1818-1824)
- Envoy Extraordinary and Minister Plenipotentiary, Spain (1825-1829)
- Commissioner, China (1845-1847)
- Everett, Edward (1794-1865)
- Envoy Extraordinary and Minister Plenipotentiary, United Kingdom (1841-1845)
- Commissioner, China (1843)
- Secretary of State (1852-1853)
- Hughes, Christopher (1786-1849)
- Chargé d'Affaires, no se (1819-1825)
- Chargé d'Affaires, Netherlands (1825-1830)
- Chargé d'Affaires, Sweden (1830-1841)
- Chargé d'Affaires, Netherlands (1842-1845)
- Jewett, Albert Gallatin (1802-1885)
- Chargé d'Affaires, Peru (1845)
- Irving, Washington (1783-1859)
- Envoy Extraordinary and Minister Plenipotentiary, Spain (1842-1846)
- Irwin, William Wallace (1803-1856)
- Chargé d'Affaires, Denmark (1843-1847)
- King, William Rufus de Vane (1786-1853)
- Envoy Extraordinary and Minister Plenipotentiary, France (1844-1846)
- McLane, Louis (1786-1857)
- Envoy Extraordinary and Minister Plenipotentiary, United Kingdom (1829-1831)
- Secretary of State (1833-1834)
- Envoy Extraordinary and Minister Plenipotentiary, United Kingdom (1845-1849)
- Lay, George Washington (1798-1860)
- Chargé d'Affaires, Sweden (1842-1845)
- Pickett, James Chamberlayne (1793-1872)
- Chargé d'Affaires, Peru (1838-1845)
- Polk, William Hawkins (1815-1862)
- Chargé d'Affaires, Two Sicilies (1845-1847)
- Rencher, Abraham (1798-1883)
- Chargé d'Affaires, Portugal (1843-1847)
- Shields, Benjamin Glover (1808-?)
- Chargé d'Affaires, Venezuela (1845-1850)
- Slidell, John (1793-1871)
- Envoy Extraordinary and Minister Plenipotentiary, Mexico (1845)
- Envoy Extraordinary and Minister Plenipotentiary, Costa Rica (1853)
- Envoy Extraordinary and Minister Plenipotentiary, El Salvador (1853)
- Envoy Extraordinary and Minister Plenipotentiary, Guatemala (1853)
- Envoy Extraordinary and Minister Plenipotentiary, Honduras (1853)
- Envoy Extraordinary and Minister Plenipotentiary, Nicaragua (1853)
- Stiles, William Henry (1808-1865)
- Chargé d'Affaires, Austria (1845-1849)
- Todd, Charles Stewart (1791-1871)
- Envoy Extraordinary and Minister Plenipotentiary, Russia (1841-1846)
- Trist, Nicholas Philip (1800-1874)
- Wheaton, Henry (1785-1848)
- Chargé d'Affaires, Denmark (1827-1835)
- Chargé d'Affaires, Germany (1835)
- Envoy Extraordinary and Minister Plenipotentiary, Germany (1837-1846)