Population Architecture using Genomics and Epidemiology (PAGE) Consortium
- Background
- Investigators
- Project Structure
- Study Design, Participants and Genotyping Characteristics of PAGE Cohorts
- Resources
- Published Manuscripts
- Steering Committee Meeting Minutes
- Contacts
Background
Genome-wide association studies have identified many genetic variants related to disease and have highlighted the need to further explore initial findings in non-European populations. The Population Architecture using Genomics and Epidemiology (PAGE) Consortium (RFA HG-07-014 and RFA HG-07-015) was formed in July 2008.
PAGE aims to examine putative causal genetic variants across approximately 100,000 African Americans, Asian Americans, American Indians, European Americans, Hispanic Americans, and Native Hawaiians from 4 groups representing 9 large U.S.-based cohorts. By coordinating genotyping and phenotype harmonization across groups, PAGE is defining the epidemiological architecture of cross-population allele frequencies, relative risks, and distribution of phenotypes associated with particular variants and their environmental modifiers.
PAGE Investigators
![Map of PAGE Investigators](https://webarchive.library.unt.edu/web/20121017011343im_/http://www.genome.gov/images/content/PAGE_investigators.gif)
Study Investigators
- Atherosclerosis Risk In Communities (ARIC)
- Coronary Artery Risk In Young Adults (CARDIA)
- Cardiovascular Health Study (CHS)
- Hispanic Community Health Study
- Strong Heart Cohort Study
- Strong Heart Family Study
Genetics Epidemiology of Causal Variants Across the Life Course (CALiCo Consortium)
Principal Investigator (PI): Kari North, Ph.D., University of North Carolina at Chapel Hill
Epidemiologic Architecture of Genes Linked to Environment (EAGLE)
Principal Investigator (PI): Dana Crawford, Ph.D., Vanderbilt University, Nashville, Tenn.
Multiethnic Cohort (MEC)
Principal Investigator (PI): Loic Le Marchand, M.D., Ph.D., University of Hawaii Cancer Research Center, Honolulu
Women's Health Initiative (WHI)
Principal Investigator (PI): Charles Kooperberg, Ph.D., Fred Hutchinson Cancer Research Center, Seattle, Wash.
Coordinating Center
Principal Investigator (PI): Tara C. Matise, Ph.D., Department of Genetics, Rutgers University, New Brunswick, N.J.Project Structure
![Diagram of project structure](https://webarchive.library.unt.edu/web/20121017011343im_/http://www.genome.gov/images/content/PAGE_structure.gif)
- The Steering Committee is the governing body for the consortium and is composed of the Principal Investigators from each institution and the NIH Project Scientist.
- The External Scientific Panel provides input to the NHGRI Director about the progress and direction of the Network.
Chair: Jonathan Haines, Ph.D., Vanderbilt University
- Mercedes Carnethon, Ph.D., Northwestern University
- Deborah Nickerson, Ph.D., University of Washington
- Christopher O'Donnell, M.D., National Heart, Lung, and Blood Institute, Harvard Medical School
- Gloria Petersen, Ph.D., Mayo Clinic
- PAGE Working Groups address issues related to phenotype harmonization (Diabetes/obesity, CVD, Cancer, Inflammation/autoimmunity, Exposures), SNP Selection and Quality Control, Ethnicity and Ancestry, Data Display and Dissemination and the Metabochip pilot.
- PAGE Standing Committees coordinate activities related to Statistical Analysis and Publications/Presentations.
- PAGE Project Groups perform cross-study analyses and write manuscripts. Current Project Groups are focused on cancer, cardiovascular disease, lipids, obesity, type 2 diabetes, menopause/menarche, the Metabochip and phenotype-wide association study (PheWAS).
Chair: Julie Buring, Sc.D., Harvard University
Study Design, Participant and Genotyping Characteristics of PAGE Cohorts
Cohort | Type of Study | Focus of Cohort | Years Collected | Length of Follow-Up | Mean Age Description | Age Range | % Women | Genotyping Platforms |
---|---|---|---|---|---|---|---|---|
EAGLE | Cross-sectional | N/A | 1991-1994, 1999-2002 |
N/A | 35 | 12-95 | 54 | Applied Biosystems TaqMan, OpenArrays TaqMan, Sequenom iPlex, Illumina BeadXpress |
MEC | Nested Case Control | Cancer | 1993-1998 | 17 years | 60 | 45-78 | 55 | Applied Biosystems TaqMan, OpenArrays TaqMan |
WHI | Cohort and Clinical Trials | Women's Health | 1993-1998 | 17 years | 63 | 50-79 | 100 | Illumina BeadXpress |
CALiCo-ARIC | Longitudinal | Cardiovascular Disease | 1987-2007 | 20 years | 54 | 45-64 | 55.1 | Applied Biosystems TaqMan |
CALiCo-CARDIA | Longitudinal | Cardiovascular Disease | 1986-2006 | 25 years | 25 | 18-30 | 54.4 | Applied Biosystems TaqMan |
CALiCo-CHS | Longitudinal | Cardiovascular Disease | 1988-1999 | 18 years | 73 | 65-100 | 57.6 | Applied Biosystems TaqMan |
CALiCo-SHS | Longitudinal | Cardiovascular Disease | 1988-Present | 22 years | 40 | 14-91 | 59.3 | Applied Biosystems TaqMan |
CALiCo-HCHS-SOL | Longitudinal | Cardiovascular Disease | 2008-Present | 2 years | 55 | 18-72 | 65 | Applied Biosystems TaqMan |
Resources
Population Architecture using Genomics and Epidemiology (PAGE) website
Published Manuscripts
Published Manuscripts related to Population Architecture using Genomics and Epidemiology (PAGE)
Steering Committee Meeting Minutes
PAGE Steering Committee Public Documents [pagestudy.org]
Contacts
Lucia Hindorff, Ph.D., M.P.H.
Project Scientist
Office of Population Genomics, NHGRI
Heather Junkins, M.S.
Health Science Analyst
Office of Population Genomics, NHGRI
Last Updated: June 18, 2012