Teri Manolio, M.D., Ph.D.

Director, Office of Population Genomics
Senior Advisor to the Director, NHGRI, on Population Genomics

Manolio TA, Collins R. Enhancing the feasibility of large cohort studies. Journal of the American Medical Association, 304:2290-91. 2010. [PubMed]

Laurie CC, Doheny KF, Mirel DB, Pugh EW, Bierut LJ, Bhangale T, Boehm F, Caporaso NE, Cornelis MC, Edenberg HJ, Gabriel SB, Harris EL Hu FB, Jacobs KB, Kraft P, Landi MT, Lumley T,. Manolio TA, McHugh C, Painter I, Paschall J, Rice JP, Rice KM, Zheng X, Weir BS, for the GENEVA Investigators. Quality control and quality assurance in genotypic data for genome-wide association studies.  Genetic Epidemiology, 34:591-602. 2010. [PubMed]

Manolio TA. Genome-wide association studies and disease risk assessment.  New England Journal of Medicine, 363:166-76. 2010. [PubMed]

Qi L, Cornelis MC, Kraft P, Stanya KJ, Kao WH, Pankow JS, Dupuis J, Florez JC, Fox CS, Paré G, Sun Q, Girman CJ, Laurie CC, Mirel DB, Manolio T, Chasman DI, Boerwinkle E, Ridker PM, Hunter D, Meigs JB, Lee CH, Meta-Analysis of Glucose and Insulin-related traits Consortium (MAGIC), Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, van Dam RM, Hu FB.  Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.  Human Molecular Genetics, 19:2706-15. 2010. [PubMed]

Cornelis MC, Agrawal A, Cole JW, Hansel NH, Barnes KC, Beaty TH, Bennett SN, Bierut LJ, Boerwinkle E, Doheny KF, Feenstra B, Feingold E, Fornage M, Haiman CA, Harris EL, Hayes MG, Heit JA, Hu FB, Kang JH, Laurie CC, Ling H, Manolio TA, Marazita ML, Matthias RA, Mirel DB, Paschall J, Pasquale LR, Pugh EW, Rice JP, Udren J, van Dam RM, Wang X, Wiggs JL, Williams K, Yu K for the GENEVA Consortium. The Gene, Environment Association Studies Consortium (GENEVA): Maximizing the knowledge obtained from GWAS by collaboration across multiple conditions. Genetic Epidemiology, 34(4):364-72. 2010. [PubMed]

Yanez ND, Burke GL, Manolio T, Gardin JM, Polak J, CHS Collaborative Research Group.  Sibling history of myocardial infarction or stroke and risk of cardiovascular disease in the elderly: The Cardiovascular Health Study. Annals of Epidemiology, 19:858-66. 2009. [PubMed]

Jacobs KB, Yeager M, Wacholder S, Craig D, Kraft P, Hunter DJ, Paschal J, Manolio TA, Tucker M, Hoover RN, Thomas GD, Chanock SJ, Chatterjee N. A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies. Nature Genetics, 41:1253-57. 2009. [PubMed]

Manolio TA, Collins FS. Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Feinberg AP, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark A, Eichler EE, Gibson G, Haines JL, Mackay TFC, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature, 461:747-53. 2009. [PubMed]

Biesecker LG, Mullikin JC, Facio FM, Turner C, Cherukuri PF, Blakesley RW, Bouffard GG, Chines PS, Cruz P, Hansen NF, Teer JK, Maskeri B, Young AC, NISC Comparative Sequencing Program, Manolio TA, Wilson AF, Finkel T, Hwang P, Arai A , Remaley AT, Sachdev V, Shamruek R, Cannon RO, Green ED. The ClinSeq Project: Piloting large-scale genome sequencing for research in genomic medicine. Genome Research, 19:1665-1674. 2009. [PubMed]

Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta J, Collins FS, Manolio TA. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proceedings of the National Academy of Sciences, 106:9362-9367. 2009. [PubMed]

Manolio TA. Collaborative genome-wide association studies of diverse diseases: Programs of the NHGRI's Office of Population Genomics. Pharmacogenomics, 10:235-241. 2009. [PubMed]

Burton PR, Hansell AL, Fortier I, Manolio TA, Khoury MJ, Little J, Elliott P. Size matters: realistic power calculations for genetic association studies in the genomics age. International Journal of Epidemiology, 38:263-73. 2009. [PubMed]

Manolio TA. Cohort studies and the genetics of complex disease. Nature Genetics, 41:5-6. 2009. [PubMed]

Manolio TA, Brooks LD, Collins FS. A HapMap harvest of insights into the genetics of common disease. Journal of Clinical Investigation, 118:1590-1625. 2008. [PubMed]

Manolio TA. Biorepositories-at the bleeding edge? International Journal of Epidemiology, 37:231-233. 2008. [PubMed]

Pearson TA, Manolio TA. How to Interpret a Genome-Wide Association Study JAMA, 299(11):1335-1344. 2008. [Full Text]

Manolio TA, Rodriguez LL, Brooks L, Abecasis G; the Collaborative Association Study of Psoriasis, Ballinger D, Daly M, Donnelly P, Faraone SV; the International Multi-Center ADHD Genetics Project, Frazer K, Gabriel S, Gejman P; the Molecular Genetics of Schizophrenia Collaboration, Guttmacher A, Harris EL, Insel T, Kelsoe JR; the Bipolar Genome Study, Lander E, McCowin N, Mailman MD, Nabel E, Ostell J, Pugh E, Sherry S, Sullivan PF; the Major Depression Stage 1 Genomewide Association in Population-Based Samples Study, Thompson JF, Warram J; the Genetics of Kidneys in Diabetes (GoKinD) Study, Wholley D, Milos PM, Collins FS. The GAIN Collaborative Research Group. New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nature Genetics, 39:1045-1051. 2007. [PubMed]

Campbell H, Manolio T. Commentary: Rare alleles, modest genetic effects, and the need for collaboration. International Journal of Epidemiology, 36:445-448. 2007. [PubMed]

Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF Jr, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM, Collins FS. NCI-NHGRI Working Group on Replication in Association Studies. Replicating genotype-phenotype associations. Nature, 447:655-660. 2007. [PubMed]

Manolio TA, Collins FS. Genes, environment, health, and disease: Facing up to complexity. Human Heredity, 63:63-66. 2007. [PubMed]

Collins FS, Manolio TA. Merging and emerging cohorts: necessary but not sufficient. Nature, 445:259. 2007. [PubMed]

Manolio TA. Taking our obligations to research participants seriously: Disclosing individual results of genetic research. American Journal of Bioethics, 6:32-34. 2006. [PubMed]

Manolio TA, Bailey-Wilson JE, Collins FS. Genes, environment, and the value of prospective cohort studies. Nature Reviews Genetics, 7:812-820. 2006. [PubMed]

Manolio TA, Boerwinkle E, O'Donnell CJ, and Wilson AF: Genetics of ultrasonographic carotid atherosclerosis. Arterioscler Thromb Vasc Biol, 24:1-10. 2004. [PubMed]

Manolio T. Novel risk markers and clinical practice. N Engl J Med 349:1587-1589. 2003. [PubMed]

Manolio TA and Bild DE. Coronary calcium, race, and genes. Arterioscler Thromb Vasc Biol, 22:359 360. 2002. [PubMed]

Top of page

Last Updated: December 8, 2010