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![DIR-header](https://webarchive.library.unt.edu/web/20121010064150im_/https://intramural.nhlbi.nih.gov/SiteCollectionImages/dir-homepage/DIR-header.jpg)
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High quality and innovative research form the foundation for the DIR research portfolio. Principal investigators in the DIR are pursuing a variety of basic and clinical research to understand better both fundamental biology and clinical pathology.
Learn more about our subject areas.
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![DIR-investigators](https://webarchive.library.unt.edu/web/20121010064150im_/https://intramural.nhlbi.nih.gov/SiteCollectionImages/dir-homepage/DIR-investigators.jpg) The DIR at NHLBI is home to over 60 basic, translational and clinical principal investigators who work independently and collaboratively to make new discoveries, translate findings, develop novel technologies, and conduct clinical research. Learn more about our principal investigators.
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We conduct a large number of research studies with patients who have diseases of the heart and blood vessels, lungs, blood cells and bone marrow, or cholesterol.
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The Office of Education supports provides training opportunities at many educational levels with an emphasis on mentoring. Providing state-of-the-art training in basic, translational, and clinical research for the next generation of scientific and clinical leaders is a high priority. Learn more about training opportunities goes here.
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Title: Mouse Hippocampus stained for NeuN and Fox-3
Date Image Taken: 8/3/2009
Image by: Dr. Keekwang Kim
Description: Co-staining (yellow) of neuronal cell nuclei in the hippocampus with anti-neuronal nuclei (NeuN, green), anti-Fox-3 (red) and DAPI (blue).
Cover of Journal of Biological Chemistry, November 2009. Kim, KK et al. LMC, NHLBI
Read more about the Laboratory of Molecular Cardiology
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Title: Mouse Hippocampus stained for NeuN and Fox-3
Date Image Taken: 8/3/2009
Image by: Dr. Keekwang Kim
Description: Co-staining (yellow) of neuronal cell nuclei in the hippocampus with anti-neuronal nuclei (NeuN, green), anti-Fox-3 (red) and DAPI (blue).
Cover of Journal of Biological Chemistry, November 2009. Kim, KK et al. LMC, NHLBI
Read more about the Laboratory of Molecular Cardiology
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Title: High fat levels in teenager with genetic orphan disorder
Date Image Taken: 09/24/2010
Image by: Dr Robert D. Shamburek and Dr. Andrew E. Arai
Description: Blood from teenager with genetic orphan disorder resulting in high triglyceride levels and pancreatitis. High levels of fat (triglyceride) in the blood separate as soon the blood is drawn from the patient.
Read more about the Advanced Cardiovascular Imaging Group.
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Title: Neuronal Cell
Date Image Taken: 04/29/2008
Image Taken By: Dr. Mathew P. Daniels
Description: Electron micrograph showing the cell skeleton of the growing end of a neuronal cell. The cell skeleton consists of dynamic filaments and tubules that control cell shape, directional growth and intracellular transport.
Read more about the Electron Microscopy Core.
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The mission of the NHLBI DIR is to perform robust scientific and clinical research leading to a better understanding of biology and clinical pathology. To attain this goal, the NHLBI DIR has a strong basic science foundation, coupled closely with innovative technology development and outstanding clinical investigators performing research both at the NIH Clinical Research Center and in partnership with local hospitals. The Office of the Scientific Director is responsible for programmatic oversight, review, and administration of the intramural research program at NHLBI.
Learn more about the Offices of the Scientific Director.
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High quality and innovative research form the foundation for the DIR research portfolio and are fundamental elements of research philosophy. Innovative, concept-based clinical research trials that are applicable to the prevention or treatment of various diseases are a focus of intramural clinical studies and partnerships with area hospitals. The DIR recruits patients from across the U.S. to enroll in innovative clinical trials at no cost to them.
Learn more about the labs and branches.
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DIR Core Facilities provide scientific resources, cutting-edge technologies and novel approaches to support the outstanding research program of its scientists. Availability of specialized expertise creates a robust environment for conducting a wide range of studies and accelerates the pace at which science discovery can take place.
Learn more about the cores.
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