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Recent News
Drinking Alcohol Shrinks Critical Brain Regions in Genetically Vulnerable Mice
Research Interests
- CNS mechanisms of addiction including alcohol, drugs and obesity.
- In-Vivo Imaging: MicroPET, MicroMRI , MicroCT, MRI, PET.
- In-Vitro Imaging: Autoradiography (Beta-Imager).
- Gene therapy techniques in preclinical models of addiction.
- Behavioral Neuropharmacology of dopamine. ADHD behavioral genetics.
- ADHD behavioral genetics.
- CNS mechanisms of stress and depression Neuronal injury, regeneration, growth factors.
- Neuronal injury, regeneration, growth factors.
- Our laboratory's main areas of interest are geared towards better understanding the mechanisms of
addiction, including: alcohol, drug abuse and obesity. Understanding these mechanisms will help us
develop better therapeutic tools for addictive disorders that amount to billions of dollars
per year in health costs and lost productivity. Based on previous findings at BNL, we focused on the
role of the dopamine D2 family of receptors (D2, D3 and D4) in alcohol abuse, by training animals to
drink alcohol. Once the animals were trained and displayed a clear preference for ethanol versus
water, a viral vector carrying the D2cDNA was strereotaxically microinfused into the brain. This resulted
in a significant decrease in alcohol intake to half the initial levels (Thanos et al. 2001). These findings
provided evidence that overexpression of D2 receptors reduced alcohol intake, and suggested that high levels
of D2 receptors may be protective against alcohol abuse (Thanos et al., 2001). These results were recently
supported in Inbred strains of alcohol preferring (P) rats (Thanos et al. 2004) and in D2R transgenic mice
(Thanos et al 2004b). Current research is utilizing various techniques (microPET brain imaging,
autoradiography, immunohistochemistry, gene transfer vectors, microdialysis, microMRI and microCT and
transgenic mouse models) to better study the neurochemistry, genetics and behavioral aspects of addiction.
Ongoing studies will help further elucidate the complex role of the D2 family of receptors in alcoholism,
drug abuse and obesity. (Figure 1)
Last Modified: September 21, 2012 Please forward all questions about this site to:
Denise Monteleone
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