Rita Z. Goldstein Scientist Telephone:  (631) 344-2657 e-mail:  rgoldstein@bnl.gov See Also:Neuropsychoimaging web site

Recent News

Gray Matter in Brain’s Control Center Linked to Ability to Process Reward

Cocaine Images Capture Motivated Attention Among Users

Research Interests

• Neuroimaging, drug addiction, neuropsychology,cognitive neuroscience
• My primary research interest lies in studying the interplay between the cognitive-emotional-behavioral and neurobiological changes that accompany cocaine addiction with the goal of understanding the mechanisms that underlie the recurring nature of addiction to drugs (intoxication, withdrawal, craving, relapse).
• In this study of the brain-behavior mechanisms that underlie drug addiction, I place a special emphasis on the role of the prefrontal cortex and the mesocortical and mesolimbic dopamine brain circuits in the impaired ability to change ongoing behavior (willed-behavior) in response to an emotionally salient feedback.
• This intricate study of the interaction between brain and behavior incorporates the interrelated yet distinct research disciplines of neuroimaging, cognitive neuroscience, and neuropsychology. My research embraces this multidisciplinary approach, translating into patient-oriented clinical research settings the principles of non-invasive techniques to measure brain function such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), event-related potential (ERP) recordings, and neuropsychology.

Current Projects

Also see Neuropsychoimaging web site: Subjects are currently being recruited for all projects.


• Does salience of money change for drug addicted individuals?
  This is an ongoing fMRI and ERP protocol where subjects are scanned in our 4 T scanner or ERPs are recorded while performing cognitive tasks under varying monetary conditions.
• How does salience of drug cues affect attentional processes and inhibitory control in drug addiction?
  Here we use cognitive tasks modified to include a salient drug-related context. Both fMRI and ERP results have been published.
• Applying computer science approaches to the study of I-RISA in addiction.
  Here we apply newly designed machine learning techniques to enhance our study of addiction and other problem behavior (e.g., aggression). This is accomplished in collaboration with Dimitris Samaras, Ph.D., at SUNY Stony Brook.
• The neuropsychology of drug addiction.
  In this project, we use neuropsychological assessment techniques to probe into the cognitive-behavioral and personality-emotional correlates of drug addiction. We use instruments such as the Stroop and Multidimensional Personality Questionnaire (MPQ) in combination with data from functional neuroimaging studies to learn about cognition (e.g., attention and working memory, inhibitory control, planning and organization, decision-making, salience attribution) and emotion (fear, anger) in drug addiction. We also modify standard neuropsychological tests for their optimal use in understanding drug addiction (drug fluency).
• Prediction of relapse in drug addiction.
  Here we use neuropsychological, fMRI and ERP results collected at a drug-free baseline to predict relapse status at follow-up in cocaine addicted individuals. Collaborations: Efrat Aharonovich, Ph.D., at Columbia University; Rajita Sinha, Ph.D., at Yale University School of Medicine.
• Extinction learning and emotional regulation in drug addiction.
  This is a project we have initiated in collaboration with Elizabeth Phelps, Ph.D., at New York University, and Mauricio Delgado, at Rutgers University, to study the neurobiological mechanisms underlying resistance to reward extinction in cocaine addicted individuals.
• Choice and insight in drug addiction.
  Here we measure choice between drug-related cues and other stimuli in addicted individuals, and its modulation by self awareness. Results have been published.

Education & Concurrent Positions

• B.A., Tel Aviv University, Tel Aviv, Israel, 1992.
• Intern, Clinical Neuropsychology, Long Island Jewish Medical Center and Hillside Hospital, NY, 1998-1999.
• Ph.D., Dept. of Psychology, Health Clinical track, University of Miami, FL (Award of Academic Merit), 1999.
• Post-doctorate research associate, training fellowship on Brain Imaging and Alcohol Abuse from the NIH, SUNY Stony Brook and Brookhaven National Laboratory, 1999-2002.
• New York State Psychology License, 2001
• Assistant Scientist, Medical Research, Brookhaven National Laboratory, Upton, NY, 2002.
• Affiliate, Department of Psychology, State University of NY at Stony Brook, 2002.
• Affiliate, Department of Biomedical Engineering, State University of NY at Stony Brook, 2003.
• Associate Scientist, Medical Research, Brookhaven National Laboratory, NY, 2004.
• Scientist, Medical Research, Brookhaven National Laboratory, 2006-2008.
• Tenured Scientist, Medical Research, Brookhaven National Laboratory, 2008-present.

Honors and Awards

• Member, American College of Neuropsychopharmacology, 01/2010.
• Outstanding Mentor Award, BNL, 06/01/2009.
• Mentored Patient-Oriented Research Career Development Award (K-23), NIDA, 2002–2007.
• Young Investigator Award, National Alliance for Research on Schizophrenia and Depression, 2003–2005.
• Woman of the Year in Science, Brookhaven Town Award, 3/22/2005.

Selected Publications

• Parvaz M.A., Konova A.B., Tomasi D., Volkow N.D., and Goldstein R.Z.
  Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward. J. Cogn. Neurosci., 24(7):1560-1570 Epub 2011 Nov 18 (July 2012).  PubMed  Full Text .pdf file
• Alia-Klein N., Parvaz M.A., Woicik P.A., Konova A.B., Maloney T., Shumay E., Wang R., Telang F., Biegon A., Wang G.J., Fowler J.S., Tomasi D., Volkow N.D., and Goldstein R.Z.
  Gene x Disease Interaction on Orbitofrontal Gray Matter in Cocaine Addiction.
  Arch Gen Psychiatry, 68(3):283-294 (2011).  PubMed  Full Text .pdf file
• Dunning J.P., Parvaz M.A., Hajcak G., Maloney T., Alia-Klein N., Woicik P.A., Telang F., Wang G.J., Volkow N.D., and Goldstein R.Z.
  Motivated attention to cocaine and emotional cues in abstinent and current cocaine users - an ERP study.
  Eur. J. Neurosci., 1-8 (2011).  PubMed  Full Text .pdf file
• Goldstein R.Z., and Volkow N.D.
  Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.
  Nat. Rev. Neurosci., 12(11):652-669. doi: 10.1038/nrn3119. (2011).  PubMed  Full Text .pdf file
• Goldstein R.Z., and Volkow N.D.
  Oral methylphenidate normalizes cingulate activity and decreases impulsivity in cocaine addiction during an emotionally salient cognitive task.
  Neuropsychopharmacology, 36(1):366-367 (2011).  PubMed  Full Text .pdf file
• Parvaz M.A., Alia-Klein N., Woicik P.A., Volkow N.D., and Goldstein R.Z.
  Neuroimaging for drug addiction and related behaviors.
  Rev. Neurosci., 22(6):609-624. Epub 2011 Nov 25. (2011).  PubMed  Full Text .pdf file
• Volkow N.D., Tomasi D., Wang G.J., Fowler J.S., Telang F., Goldstein R.Z., Alia-Klein N., Woicik P., Wong C., Logan J., Millard J., and Alexoff D.
  Positive emotionality is associated with baseline metabolism in orbitofrontal cortex and in regions of the default network.
  Molecular Psychiatry , 1–8 (2011).  PubMed  Full Text .pdf file
• Volkow N.D., Tomasi D., Wang G.J., Fowler J.S., Telang F., Goldstein R.Z., Alia-Klein N., and Wong C.
  Reduced Metabolism in Brain "Control Networks" following Cocaine-Cues Exposure in Female Cocaine Abusers.
  PLoS One, 6(2):e16573 (2011). PubMed  Full Text .pdf file
• Volkow N.D., Baler R.D., and Goldstein R.Z.
  Addiction: pulling at the neural threads of social behaviors.
  Neuron, 69(4):599-602 (2011). PubMed  Full Text .pdf file
• Woicik P.A., Urban C., Alia-Klein N., Henry A., Maloney T., Telang F., Wang G.J., Volkow N.D., and Goldstein R.Z.
  A pattern of perseveration in cocaine addiction may reveal neurocognitive processes implicit in the Wisconsin Card Sorting Test.
  Neuropsychologia, 49(7):1660-1669 (2011). Epub 2011 Mar 15. PubMed  Full Text .pdf file
• Asensio S., Romero M.J., Romero F.J., Wong C., Alia-Klein N., Tomasi D., Wang G.-J., Telang F., Volkow N.D., and Goldstein R.Z.
  Dopamine D2 receptor availability predicts thalamic and medial prefrontal response to reward in cocaine addiction.
  Synapse, 64(5):397-402 (2010). PubMed  Full Text .pdf file
• Caparelli E.C., Backus W., Telang F., Wang G.-J., Maloney T., Goldstein R.Z., Anschel D., Henn F.
  Simultaneous TMS-fMRI of the visual cortex reveals functional network, even in absence of phosphene sensation.
  The Open Neuroimaging Journal, 4:100-110 (2010). Full Text .pdf file
• Goldstein R.Z., Woicik P.A., Maloney T., Tomasi D., Alia-Klein N., Shan J., Carrillo J.H., Samaras D., Wang R., Telang F., Wang G.-J., Volkow N.D.
  Given with a cognitive task, methylphenidate corrects prefrontal dysfunction in cocaine addiction.
  PNAS, 107(38):16667-16672. Featured on MDLinx.com. Full Text .pdf file
• Goldstein R.Z., Woicik P.A., Maloney T., Tomasi D., Alia-Klein N., Shan J., Honorio J., Samaras D., Wang R., Telang F., Wang G.J., and Volkow N.D.
  Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task.
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (USA), 107(38):16667-16672 (2010).  PubMed 
• Goldstein R.Z., Woicik P.A., Moeller S.J., Telang F., Jayne M., Wong C., Wang G.-J., Fowler J.S., and Volkow N.D.
  Liking and Wanting of Drug and Non-Drug Rewards in Active Cocaine Users: the STRAP-R Questionnaire.
  Journal of Psychopharmacology, 24(2):257-266 (2010). PubMed  Full Text .pdf file
• Moeller S.J., Maloney T., Parvaz M.A., Alia-Klein N., Woicik P.A., Telang F., Wang G.J., Volkow N.D., and Goldstein R.Z.
  Impaired insight in cocaine addiction: laboratory evidence and effects on cocaine-seeking behaviour.
  Brain, 133(5):1484-1493. (May 2010);Epub 2010 Apr 15. PubMed  Full Text .pdf file
• Tomasi D., Volkow N.D., Wang R., Carrillo J.H., Maloney T., Alia-Klein N., Woicik P.A., Telang F., and Goldstein R.Z.
  Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers.
  PLoS One, 25;5(5):e10815 (May 2010). PubMed  Full Text .pdf file
• Volkow N.D., Wang G.-J., Newcorn J.H., Kollins S.H., Wigal T.L., Telang F., Fowler J.S., Goldstein R.Z., Klein N., Logan J., Wong C., Swanson J.M. Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Mol Psychiatry, (Sep 21), 1-8 (2010). PubMed  Full Text .pdf file
• Volkow N.D., Wang G.-J., Tomasi D., Telang F., Fowler J.S., Pradhan K., Jayne M., Logan J., Goldstein R.Z., Alia-Klein N., Wong C.
  Methylphenidate Attenuates Limbic Brain Inhibition After Cocaine-Cues Exposure In Cocaine Abusers.
  PLoS One, 5(7):e11509 (2010). PubMed  Full Text .pdf file
• Wang R., Wang G.-J., Goldstein R.Z., Caparelli E.C., Volkow N.D., Fowler J.S., and Tomasi D.
  Induced magnetic force in human heads exposed to 4-Tesla MRI.
  Journal of Magnetic Resonance Imaging, 31:815-820 (2010). PubMed  Full Text .pdf file
• Goldstein R.Z., Craig A.D., Bechara A., Garavan H., Childress A.R., Paulus M.P., and Volkow N.D.
  The Neurocircuitry of Impaired Insight in Drug Addiction.
  Trends Cogn Sci., 13:372-380 (2009). [Epub ahead of print]. PubMed  Full Text .pdf file
• Goldstein R.Z., Alia-Klein N., Tomasi D., Honorio Carrillo J., Maloney T., Woicik P.A., Wang R., Telang F., and Volkow N.D.
  Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction.
  PNAS, Published online before print May 28, 2009, doi: 10.1073/pnas.0900491106, (2009).   Full Text .pdf file
• Alia-Klein N., Goldstein R.Z., Tomasi D., Woicik P.A., Moeller S.J., Williams B., Craig I.W., Telang F., Biegon A., Wang G.-J., Fowler J.S., and Volkow N.D.
  Neural Mechanisms of Emotion Regulation as a Function of Genetic Risk for Violence.
  Emotion, 9(3):385-396 (2009).   PubMed  Full Text .pdf file
• Goldstein R.Z., Tomasi D., Alia-Klein N., Carrillo J.H., Maloney T., Woicik P.A., Wang R., Telang F., and Volkow N.D.
  Dopaminergic response to drug words in cocaine addiction.
  Journal of Neuroscience, 29(18):6001-6006 (2009).   Press Release  PubMed  Full Text .pdf file
• Moeller S.J., Maloney T., Parvaz M.A., Dunning J.P., Alia-Klein N., Woicik P.A., Hajcak G., Telang F., Wang G.-J., Volkow N.D., and Goldstein R.Z.
  Behavioral preference for cocaine pictures in cocaine addiction: results of two novel choice tasks.
  Biological Psychiatry, in press. Cited by Kent Berridge: Faculty of 1000 Biology, 5 May 2009,  (2009). Full Text .pd file
• Volkow N.D., Wang G.-J., Telang F., Fowler J.S., Goldstein R.Z., Alia-Klein N., Logan J., Wong C., Thanos P.K., Ma Y., and Pradhan K.
  Inverse Association between BMI and Prefrontal Metabolic Activity in Healthy Adults.
  Obesity, 17(1):60-65 (2009).  PubMed or Full Text .pdf file
• Woicik P.A., Moeller S.J., Alia-Klein N., Maloney T., Lukasik T., Yeliosof O., Wang G.-J., Volkow N.D., and Goldstein R.Z.
  The Neuropsychology of Cocaine Addiction: Recent Cocaine Use Masks Impairment.
  Neuropsychopharmacology, 34(5):1112-1122 (2009).  PubMed  Full Text .pdf file
• Alia-Klein N., Goldstein R.Z., Logan J., Tomasi D., Kriplani A., Telang F., Shumay E., Biegon A., Henn F., Wang G.-J., Volkow N.D. and Fowler J.S.
  Brain MAO A Activity Associated with Trait Aggression.
  Journal of Neuroscience, 28(19), 5099-5104 (2008).  PubMed or Full Text .pdf file
• Alia-Klein N., Kriplani A., Pradhan K., Ma J.-Y., Logan J., Williams B., Craig I.W., Telang F., Tomasi D., Goldstein R.Z., Wang G.-J., Volkow N.D. and Fowler J.S.
  The MAO A genotype does not modulate resting brain metabolism in adults.
  Psychiatry Research: Neuroimaging, in press (2008). Full Text .pdf file
• Goldstein R.Z., Parvaz M.A., Maloney T., Alia-Klein N., Woicik P.A., Telang F., Wang G.-J. and Volkow N.D.
  Compromised sensitivity to monetary reward in current cocaine users: an ERP study.
  Psychophysiology, May 29, 2008; [Epub ahead of print].  PubMed or Full Text .pdf file
 
• Tomer R., Goldstein R.Z., Wang G.-J., Wong C. and Volkow N.D.
  Incentive motivation is associated with asymmetry in striatal markers of dopamine neurotransmission.
  Biol. Psychol., 77(1):98-101 (2008).  PubMed or Full Text .pdf file
• Alia-Klein N., Goldstein R.Z., Tomasi D., Zhang L., Telang F., Wang G.-J., Fowler J.S. and Volkow N.D.
  What is in a word? No versus Yes differentially activate the lateral orbitofrontal cortex.
  Emotion, 7(3):649-659 (2007).  PubMed or Full Text .pdf file
• Alia-Klein N., O'Rourke T., Goldstein R.Z. and Malaspina D.
  Insight into illness and adherence to psychotropic medications predict violence severity in a forensic sample.
  Aggressive Behavior, 33(1):86-96 (2007).  PubMed or Full Text .pdf file
• Fowler J.S., Alia-Klein N., Kriplani A., Logan J., Williams B., Zhu W., Craig I.W., Telang F., Goldstein R., Volkow N.D., Vaska P. and Wang G.-J.
  Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects.
  Biological Psychiatry, 62(4):355-358 (2007). PubMed or Full Text .pdf file
• Goldstein R.Z., Alia-Klein N., Tomasi D., Zhang L., Cottone L.A., Maloney T., Telang F., Caparelli E.C., Chang L., Ernst T., Samaras D., Squires N.K. and Volkow N.D.
  Is decreased prefrontal cortical sensitivity to monetary reward is associated with impaired motivation and self-control in cocaine addiction.
  American Journal of Psychiatry, 164(1):43-51 (2007).  PubMed or Full Text .pdf file
• Goldstein R.Z., Tomasi D., Alia-Klein N., Zhang L., Telang F. and Volkow N.D.
  The effect of practice on a sustained attention task in cocaine abusers.
  Neuroimage, 35(1):194-206 (2007).  PubMed or Full Text .pdf file
• Goldstein R.Z., Tomasi D., Rajaram S., Cottone L.A., Zhang L., Maloney T., Telang F., Alia-Klein N. and Volkow N.D.
  Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction.
  Neuroscience, 144(4):1153-1159 (2007).  PubMed or Full Text .pdf file
• Goldstein R.Z., Woicik P.A., Lukasik T., Maloney T. and Volkow N.D.
  Drug Fluency: A Potential Marker for Current Cocaine Abuse.
  Drug and Alcohol Dependence, 89(1):97-101 (2007).  PubMed or Full Text .pdf file
• Tomasi D., Goldstein R.Z., Telang F., Maloney T., Alia-Klein N., Caparelli E.C. and Volkow N.D.
  Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception.
  Psychiatry Research: Neuroimaging, 155(3):189-201 (2007). PubMed or Full Text .pdf file
• Tomasi D., Goldstein R.Z., Telang F., Maloney T., Alia-Klein N., Caparelli E.C. and Volkow N.D.
  Widespread disruption in brain activation patterns to a working memory task during cocaine abstinence.
  Brain Research, 1171:83-92 (2007).  PubMed or Full Text .pdf file
• Goldstein R.Z., Cottone L.A., Jia Z., Maloney T., Volkow N.D. and Squires N.K.
  The effect of graded monetary reward on cognitive event-related potentials and behavior in young healthy adults.
  International Journal of Psychophysiology, 62(2):272-279 (2006).  PubMed or Full Text .pdf file
• Goldstein R.Z., Tomasi D., Alia-Klein N., Cottone L.A., Zhang L., Telang F. and Volkow N.D.
  Subjective sensitivity to gradients in monetary reward in cocaine abusers are associated with the orbitofrontal cortex.
  Drug and Alcohol Dependence, 87(2-3):233-240 (2006). PubMed or Full Text .pdf file
• Volkow N.D., Wang G.-J., Begleiter H., Porjesz B., Fowler J.S., Telang F., Ma Y., Wong C., Logan J., Goldstein R.Z., Thanos P.K. and Alexoff D.
  High Dopamine D2 Receptors in Unaffected Members of Alcoholic Families: Possible Protective Factors. Archives of General Psychiatry, 63:999-1008 (2006).  PubMed or Full Text .pdf file
• Goldstein R.Z., Alia-Klein N., Leskovjan A.C., Fowler J.S., Wang G.-J., Gur R.C., Hitzemann R. and Volkow N.D.
  Anger and depression in cocaine addiction: association with the orbitofrontal cortex.
  Psychiatry Research: Neuroimaging, 138(1):13-22 (2005).  PubMed or Full Text .pdf file
• Goldstein R.Z., Leskovjan A.C., Hoff A.L., Hitzemann R., Bashan F., Khalsa S.S., Wang G.-J., Fowler J.S. and Volkow N.D.
  Severity of neuropsychological impairment in drug addiction: association with metabolism in the brain reward circuit.
  Neuropsychologia, 42(11):1447-1458 (2004). *5th most heavily downloaded, 7/05. PubMed or Full Text .pdf file
• Giovannetti T., Goldstein R.Z., Schullery T.M., Barr W.B. and Bilder R.M.
  Category fluency in first episode schizophrenia.
  Journal of the International Neuropsychological Society, 9(3):384-393 (2003).  PubMed or Full Text .pdf file
• Goldstein R.Z., Giovannetti T., Schullery T.M., Zuffante P., Lieberman J.A., Robinson D.G., Barr W.B. and Bilder R.M.
  Neurocognitive correlates of response to treatment in formal thought disorder in first-episode schizophrenia.
  Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 15(2):88-98 (2002). PubMed or Full Text .pdf file
• Goldstein R.Z. and Volkow N.D.
  Drug Addiction and its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex.
  American Journal of Psychiatry, 159(10):1642-1652 (2002).  *Cited >200 times. PubMed or Full Text .pdf file
 
• Goldstein R.Z., Volkow N.D., Chang L., Wang G.-J., Fowler J.S., Depue R.A. and Gur R.C.
  The Orbitofrontal Cortex in Methamphetamine Addiction: Involvement in Fear.
  NeuroReport, 13(17):1-5 (2002).  PubMed or Full Text .pdf file
• Volkow N.D., Fowler J.S., Wang G.-J. and Goldstein R.Z.
  Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies.
  Neurobiology of Learning and Memory, 2002; 78(3):610-624.  PubMed or Full Text .pdf file
• Goldstein R.Z., Hurwitz B.E., Llabre M.M., Schneiderman N., Gutt M., Skyler J.S., Prineas R.J. and Donahue R.P.
  Modeling preclinical cardiovascular risk for use in epidemiologic studies: Miami community health study.
  American Journal of Epidemiology, 154(8):765-776 (2001).  PubMed or Full Text .pdf file
• Goldstein R.Z., Volkow N.D., Wang G.-J., Fowler J.S. and Rajaram S.
  Addiction changes orbitofrontal gyrus function: involvement in response inhibition.
  NeuroReport, 12(11):2595-2599 (2001).  PubMed or Full Text .pdf file
• Goldstein R., Harvey A.S., Duchowny M., Jayakar P., Altman N., Resnick T., Levin B., Dean P. and Alvarez L.
  Preoperative clinical, EEG, and imaging findings do not predict seizure outcome following temporal lobectomy in childhood.
  Journal of Child Neurology, 1(6):445-450 (1996).  PubMed or Full Text .pdf file
• Raz S., Goldstein R., Hopkins T.L., Lauterbach M.D., Shah F., Porter C.L., Riggs W.W., MaGill L.H. and Sander C.J.
  Sex differences in early vulnerability to cerebral injury and their neurodevelopmental implications.
  Psychobiology, 22(3):244-253 (1994).  Full Text .pdf file

Full Length Proceedings

• Honorio J.C., Ortiz L., Samaras D., Paragios N., and Goldstein R.Z.
  Sparse and Locally Constant Gaussian Graphical Models.
  In Advances in NIPS, accepted (2009).
• Honorio J.C., Samaras D., Tomasi D., and Goldstein R.Z.
  Simple fully automated group classification brain fMRI.
  International Symposium on Biomedical Imaging (ISBI), accepted.
• Langs G., Samaras D., Paragios N., Honorio J., Alia-Klein N., Tomasi D., Volkow N.D., and Goldstein R.Z.
  Task-Specific Functional Brain Geometry from Model Maps.
  In Proc Medical Image Computing and Computer Assisted Intervention, pp. 925-933 (2008).
• Zhang L., Samaras D., Alia-Klein N., Volkow N.D. and Goldstein R.
  Modeling Neuronal Interactivity using Dynamic Bayesian Networks.
  In Advances in Neural Information Processing Systems 18, Y. Weiss, B. Scholkopf, and J. Platt, Eds. MIT Press, Cambridge, MA., (2006).
• Zhang L., Samaras D., Volkow N.D. and Goldstein R.
  Machine Learning for Clinical Diagnosis from Functional Magnetic Resonance Imaging (#169).
  In IEEE Proc. of Computer Vision and Pattern Recognition, I:1211-1217, (2005).
• Zhang L., Samaras D., Tomasi D., Alia-Klein N., Cottone L.A., Leskovjan L.C., Volkow N.D. and Goldstein R.
  Exploiting Temporal Information in Functional Magnetic Resonance Imaging Brain Data.
  Medical Image Computing and Computer Assisted Intervention, pp.679-687, (2005).

Book Chapters

• Goldstein RZ, Moeller SJ, and Volkow ND.
  Cognitive disruptions in drug addiction: a focus on the prefrontal cortex.
  In B Adinoff and E Stein (Eds.), Neuroimaging in the Addictions. Weily, in press. (2011).
• Woicik P.A., Alia-Klein N., Volkow N.D., and Goldstein R.Z.
  Neuroimaging in Human Drug Addiction.
  In D Borsook, L Becerra, E Bullmore & R Hargreaves (Eds.), Imaging in Drug Development. Springer, New York, pp. 263-289 (2010).
• Goldstein R.Z.
  Abnormalities in monetary and other non-drug reward processing in drug addiction.
  In E Phelps, MR Delgado, TW Robbins (Eds.), Attention and Performance: Decision Making. Oxford University Press, in press.
• Goldstein R.Z., Alia-Klein N. and Volkow N.D.
  Drugs of Addiction: Neuroimaging.
  In Larry R Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, (2008).
• Goldstein R.Z., Alia-Klein N., Cottone L.A. and Volkow N.D.
  Addiction and the Orbitofrontal Cortex.
  In D Zald & S Rauch (Eds.), The Orbitofrontal Cortex. Oxford University Press, (2006).
• Volkow N.D., Wang G.-J., Fowler J.S. and Goldstein R.Z.
  Imaging the Addicted Brain.
  In BK Madras, CM Colvis, JD Pollock, JL Rutter, D Shurtleff, & MV Zastrow (Eds.), Cell Biology of Addiction. The Cold Spring Harbor Laboratory Press, (2006).
• Hurwitz B.E., Goldstein R., Massie C.A., Llabre M.M. and Schneiderman N.
  Low-flow circulatory state and the pathophysiological development of cardiovascular disease: A model of autonomic mediation of cardiovascular regulation.
  In P.M. McCabe, N. Schneiderman, T. Field, & A. R. Wellens (Eds.), Stress, Coping, and Cardiovascular Disease. Lawrence Erlbaum Associates. Mahwah, NJ, pp. 85-122, (2000).  

Media Interviews

• BNL (“Cocaine Images Capture Motivated Attention Among Users But recent drug use diminishes response to drug images and other emotional stimuli over time”) 04/04/11.
• BNL (“Genetic Makeup and Duration of Abuse Reduce the Brain's Neurons in Drug Addiction”), consequently, press releases in: Science Daily, Bloomberg Businessweek, U.S. News & World Report, Yahoo! News, Eureka Science News 03/07/11.
• BNL (“Ritalin Improves Brain Function, Task Performance in Cocaine Abusers”, press release) 09/06/10
• BNL (“Brain-Behavior Disconnect in Cocaine Addiction: Impaired ability to monitor behavior, emotions may underlie vulnerability to drugs; suggests new targets for treatment”, a press release) 05/25/09.
• Neurology Today, published by Lippincott Williams & Wilkins for members of the American Academy of Neurology (“Brain Mechanisms Needed to Overcome Addiction are Impaired, New Studies Suggest” by Tom Valeo). 2/19/09
• Reuters Health (“Addicts prefer drug imagery to pleasant scenes” by A. Harding) 11/18/08
• UPI.com (“Preference for cocaine extends to images”) 11/18/08
• A press conference on ‘Why Can't I Forget My Last Fix?’ at the SFN 2008 Annual Meeting, Washington DC.
  Consequently: BNL press release ("Insight Deficit May Explain Denial in Drug Addiction") 11/16/08
• BNL (“Cocaine abuse blunts sensitivity to monetary reward”, a press release), featured in Join Together, an online source for understanding addiction. 11/15/07
• Society for Nuclear Medicine featured our research as 2007 Image of the Year.
• Something of Substance, interview and TV documentary on alcoholism, substance abuse and mental health, Suffolk County Dept. of  Health Services, by M. Myers, aired April, 2007.
• Conversations with six leading neuroscientists on timely topics in brain research: Addiction and the +Prefrontal Cortex, Dana Foundation Press: featured in the 2007 Advances in Brain Research: Brain Work, by B. Patoine, 2/28/07.
• Riddle of addiction lures researchers: complex network of brain mechanisms underlies cravings, San Francisco Chronicle, by C. Hall, 2/11/07.
• Combating Addiction, Congressional Quarterly Research, by M. Clemmitt, 2/9/07.
• The Leonard Lopate Show on WNYC, New York Public Radio: Brief Histories, Please Explain: Cocaine, 01/12/07. Listen or download from: http://www.wnyc.org/shows/lopate/episodes/2007/01.
• Cocaine alters brain cells, impairs impulse control, Reuters Health, by M. Kerr, 10/18/06.
• How drug skews values, Newsday, by J. Talan, 10/17/06.
• A press conference by the Society for Neuroscience in 2006.
• Altered Perception of Reward in Human Cocaine Addiction, Press release by Brookhaven National Laboratory, 10/15/06. Appeared also on: http://www.medicalnewstoday.com.
• A documentary of drug addiction for the RAI Italian National TV Channel, by Marco Rosi of DocLab Productions, 2006.
• Addicts' Brains Work Harder to Control Behavior, Press release by Brookhaven National Laboratory, 12/3/02.
• Brain Matter, North Shore Sun, by A. Clancy, 10/25/02.

Brookhaven Lectures

• Rita Goldstein, Ph.D., Medical Department, "Self-Control in Cocaine Addiction", October 1, 2008.

Full Length CV

Last Modified: September 21, 2012
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One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE's Office of Science by Brookhaven Science Associates, a limited-liability company founded by the Research Foundation for the State University of New York on behalf of Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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