The search textbox has an autosuggest feature. When you enter three or more characters,
a list of up to 10 suggestions will popup under the textbox. Use the arrow keys
to move through the suggestions. To select a suggestion, hit the enter key. Using
the escape key closes the listbox and puts you back at the textbox. The radio buttons
allow you to toggle between having all search items start with or contain the text
you entered in the search box.
![](https://webarchive.library.unt.edu/web/20120927143041im_/http://www.cancer.gov/images/spacer.gif)
crizotinib
![Patient Information Patient Information](https://webarchive.library.unt.edu/web/20120927143041im_/http://www.cancer.gov/images/btn-patient-info.gif)
An orally available aminopyridine-based inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the c-Met/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Crizotinib, in an ATP-competitive manner, binds to and inhibits ALK kinase and ALK fusion proteins. In addition, crizotinib inhibits c-Met kinase, and disrupts the c-Met signaling pathway. Altogether, this agent inhibits tumor cell growth. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/web/20120927143041im_/http://www.cancer.gov/images/spacer.gif)
Synonyms: | ![]() | c-met/hepatocyte growth factor receptor tyrosine kinase inhibitor PF-02341066 c-met/HGFR tyrosine kinase inhibitor PF-02341066 MET Tyrosine Kinase Inhibitor PF-02341066 | |
![]() | |||
US brand name: | ![]() | Xalkori | |
![]() | |||
Code name: | ![]() | PF-02341066 | |
![]() | |||
Chemical structures: | ![]() | 2-Pyridinamine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H- pyrazol-4-yl] 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4- yl)pyridin-2-amine | |
![]() |