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gemcitabine hydrochloride
The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | difluorodeoxycytidine hydrochloride gemcitabine | |
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| US brand name: | | Gemzar | |
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| Abbreviations: | | dFdC dFdCyd | |
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| Code name: | | LY-188011 | |
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| Chemical structures: | | 1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose hydrochloride 2'-deoxy-2',2'-difluorocytidine hydrochloride 2'deoxy-2',2'-difluorocytidine hydrochloride | |
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