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tegafur
A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names: | Florafur Fluorofur | ||
Foreign brand names: | Citofur Coparogin Exonal Fental ftorafur Ftoral Ftoralon Fulaid Fulfeel Furafluor Furofutran Futraful Lamar Lifril Neberk Nitobanil Riol Sinoflurol Sunfural Tefsiel Utefos | ||
Abbreviation: | FT | ||
Code names: | FT-207 MJF-12264 WR-220066 | ||
Chemical structures: | 5-fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione 5-fluoro-1-(tetrahydro-2-furyl)-uracil N1-(2'-furanidyl)-5-fluorouracil | ||