* |
Summary:
Description:
Additional Technical Details:
Urine-based SRMs for drugs of abuse were first developed in the late 1980s and early 1990s with materials intended for 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-9-COOH) (the primary marijuana metabolite) (SRM 1507), cotinine (a nicotine metabolite) (RM 8444), cocaine and cocaine metabolite (SRM 1508), morphine and codeine (SRM 2381), and morphine glucuronide (SRM 2382). All the SRMs were certified using multiple analytical methods, primarily isotope dilution GC/MS methods. In 1992 the first hair matrix RMs for drugs of abuse were prepared by soaking hair in dimethylsulfoxide (DMSO) solutions with four target drugs. The two hair RMs were replaced in 2002 by SRM 2379 and 2380 Drugs of Abuse in Hair, which were again prepared by soaking in DMSO with nine drugs (different drugs in each material), but were assigned certified values based on measurements by using ID GC/MS and ID LC/MS. A third matrix for drugs of abuse, serum, will be issued in early 2009 with values for seven drugs, including two (methadone and nordiazepam) that have not been measured in previous matrices. The SRMs and RMs for drugs of abuse in urine, hair, and serum are summarized in Table 1. In recent years the Division has been providing support to DHS in the general area of standards development for chemical measurements primarily in the area of trace explosives detection. The first explosives material issued in 2004, RM 8107 Additives in Smokeless Powder, was developed to help assure the quality of ‘low explosives’ type measurements. The first SRM for high explosives, SRM 2905 Trace Particulate Explosives, will be available in early 2009. These explosives reference materials, and others in progress, are intended for use in calibrating and evaluating the sensitivity and reliability of trace explosive detection equipment. A beryllium oxide SRM have also been developed in collaboration with DoE and NIOSH to support measurements for assessment of potential aerospace and defense industry worker exposure to beryllium. A new project, in conjunction with the CPSC, will develop tools for the validation of test methods for lead in paint on children’s products, with the eventual goal of providing an SRM to validate test methods for both product screening and compliance enforcement testing. The Analytical Chemistry Division is part of a larger DoD-supported program within CSTL to provide analytical methods development, quality assurance of measurements, and analysis of high-priority samples to support the mission of this DoD agency. |
End Date:OngoingLead Organizational Unit:mmlRelated Programs and Projects:Determination of Traces of Fissionable Materials using Delayed Neutron Activation Analysis Associated Products:SRMs 1507, 1508, 2382 Individual Drugs of Abuse in Urine - THC-9-COOOH, benzoylecgonine, morphine glucuronide SRM 1511 Multi-Drugs of Abuse in Urine - Benzoylecgonine, morphine, codeine, THC-9-COOH, phencyclidine SRM 2381 Morphine and Codeine in Urine - Morphine, codeine RM 8444 Cotinine in Urine - Cotinine SRMs 2379, 2380 Multi-Drugs of Abuse in Hair - Amphetamine, benzoylecgonine, cocaethylene, cocaine, codeine, methamphetamine, G-monoacetymorphine, morphine, phencyclidine, THC SRMs 1828, 1847, 2891-2900 Ethanol-Water Solutions - Ethanol SRM 2285 Arson Test Mixture in Methylene Chloride - Aliphatic hydrocarbons, p-xylene, 2-ethyltoluene, 3-ethyltoluene, 1,2,4-trimethylbenzene RM 8107 Additives in Smokeless Powder - Nitroglycerin, diphenylamine, N-nitroso-diphenylamine, ethyl centralite SRM 2905 Trace Particulate Explosive Simulants - TNT, RDX, HMX SRM 2906 Trace Explosives Calibration Solutions – values assigned for RDX, PETN, TNT SRMs 1878, 1879 Respirable Alpha Quartz and Cristobalite - Alpha quartz, cristobalite SRM 1877 Beryllium Oxide Powder - Beryllium SRM 2570-2582 Lead Paint Film and Lead in Powdered Paint - Lead Contact
Stephen A. Wise Lane C. Sander Gregory C. Turk |