NIH Clinical Alerts and Advisories
NLM began offering clinical alert notices online in January 1991. Clinical alerts are provided to expedite the release of findings from the NIH-funded clinical trials where such release could significantly affect morbidity and mortality. Links to clinical alerts are provided below.
- There are currently:
- 34 clinical alerts
- 8 clinical advisories
To subscribe to an RSS feed to notify you of a new clinical alert or advisory paste this URL into your Reader: http://www.nlm.nih.gov/rss/auto/ClinicalAlerts.rss
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- Commonly Used Three-drug Regimen for Idiopathic Pulmonary Fibrosis Found Harmful
NIH Stops One Treatment Arm of Trial; Other Two Treatments to Continue - National Heart, Lung, and Blood Institute (NHLBI)
- October 21, 2011
- Angioplasty Combined with Stenting Plus Aggressive Medical Therapy vs. Aggressive Medical Therapy Alone for Intracranial Arterial Stenosis: NINDS Stops Trial Enrollment Due to a Higher Risk of Stroke and Death in the Stented Group
- National Institute of Neurological Disorders and Stroke (NINDS)
- April 11, 2011
- NHLBI Stops Study of Treatment for Pulmonary Hypertension in Patients with Sickle Cell Disease Due to Safety Concerns
- National Heart, Lung, and Blood Institute (NHLBI)
- July 28, 2009
- Immunizations Are Discontinued in Two HIV Vaccine Trials
- National Institute of Allergy and Infectious Diseases (NIAID)
- September 21, 2007
- International HIV/AIDS Trial Finds Continuous Antiretroviral Therapy Superior to Episodic Therapy
- National Institute of Allergy and Infectious Diseases (NIAID)
- January 18, 2006
- Use of Non-Steroidal Anti-Inflammatory Drugs Suspended in Large Alzheimer's Disease Prevention Trial
- National Institute on Aging (NIA)
- December 22, 2004
- NHLBI Stops Study Testing How Long Children with Sickle Cell Anemia Should Have Blood Transfusions to Prevent Stroke
- National Heart, Lung, and Blood Institute (NHLBI)
- December 6, 2004
- NIH Asks Participants in Women’s Health Initiative Estrogen-Alone Study to Stop Study Pills, Begin Follow-up Phase
- National Heart, Lung, and Blood Institute (NHLBI)
- March 2, 2004
- New Treatment Significantly Improves Long-term Outlook For Breast Cancer Survivors:
International clinical trial concludes women should consider taking letrozole after five years of tamoxifen treatment to continue to reduce risk of recurrence - National Cancer Institute (NCI)
- October 9, 2003
- Low Dose Warfarin Prevents Recurrence of Blood Clots - NHLBI Stops Study
- National Heart, Lung, and Blood Institute (NHLBI)
- February 24, 2003
- NHLBI Stops Trial of Estrogen Plus Progestin Due to Increased Breast Cancer Risk, Lack of Overall Benefit
- National Heart, Lung, and Blood Institute (NHLBI)
- July 09, 2002
- NHLBI-Funded Emphysema Study Finds Certain Patients at High Risk for Death Following Lung Surgery
- National Heart, Lung, and Blood Institute (NHLBI)
- August 15, 2001
- Diet and Exercise Dramatically Delay Type 2 Diabetes; Diabetes Medication Metformin Also Effective
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- August 8, 2001
- Chronic Lyme Disease Symptoms Not Helped by Intensive Antibiotic Treatment
- National Institute of Allergy and Infectious Disease (NIAID)
- June 12, 2001
- Enbrel® Shown Safe, Effective in Children and Teenagers with Juvenile Rheumatoid Arthritis
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- March 17, 2000
- NHLBI Stops Part of Study - High Blood Pressure Drug Performs No Better Than Standard Treatment
- National Heart, Lung, and Blood Institute (NHLBI)
- March 8, 2000
- Periodic Transfusions Lower Stroke Risk in Children with Sickle Cell Anemia
- National Heart, Lung, and Blood Institute (NHLBI)
- September 18, 1997
- Adjuvant Therapy of Breast Cancer - Tamoxifen Update.
- National Cancer Institute (NCI)
- November 30, 1995
- To Ophthalmologists -- Findings from the Endophthalmitis Vitrectomy Study (EVS).
- National Eye Institute (NEI)
- October 13, 1995
- Bypass Over Angioplasty for Patients With Diabetes.
- National Heart, Lung, and Blood Institute (NHLBI)
- September 21, 1995
- Drug Treatment for Sickle Cell Anemia Announced January 30, 1995.
- National Heart, Lung, and Blood Institute (NHLBI)
- January 30, 1995
- National Eye Institute Announces Ischemic Optic Neuropathy Decompression Trial (IONDT) Findings.
- National Eye Institute (NEI)
- January 3, 1995
- Clinical Advisory on Carotid Endarterectomy for Patients With Asymptomatic Carotid Artery Stenosis.
- National Institute of Neurological Disorders and Stroke (NINDS)
- September 28, 1994
- Important Therapeutic Information on the Benefit of Zidovudine (AZT) for the Prevention of the Transmission of HIV from Mother to Infant.
- National Institute of Allergy and Infectious Diseases (NIAID)
- February 22, 1994
- Important Therapeutic Information on Treatment of HIV Infection in HIV-Infected Patients Who Are Intolerant of or Have Failed Zidovudine Therapy.
- National Institute of Allergy and Infectious Diseases (NIAID)
- February 1, 1993
- Findings from the Optic Neuritis Treatment Trial.
- National Eye Institute (NEI)
- February 28, 1992
- Findings of the Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial.
- National Eye Institute (NEI)
- October 29, 1991
- Important Therapeutic Information on Prevention of Recurrent Pneumocystis Carinii Pneumonia in Persons with AIDS.
- National Institute of Allergy and Infectious Diseases (NIAID)
- October 21, 1991
- Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.
- National Heart, Lung, and Blood Institute (NHLBI)
- July 31, 1991
- Results of the NHLBI and NIA clinical trial of the efficacy of antihypertensive treatment for isolated systolic hypertension in those aged 60 years and older.
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institute on Aging (NIA)
- June 26, 1991
- Benefits of adjuvant therapy for rectal cancer.
- National Cancer Institute (NCI)
- March 13, 1991
- Benefit of carotid endarterectomy for patients with high-grade stenosis of the internal carotid artery.
- National Institute of Neurological Disorders and Stroke (NINDS)
- February 26, 1991
- Results of the NICHD clinical trial of the efficacy of intravenous immunoglobulin (IVIG) for the prophylaxis of serious bacterial infections in symptomatic HIV-infected children.
- National Institute of Child Health and Human Development (NICHD)
- January 18, 1991
- Secondary Prevention of Small Subcortical Strokes Trial: NINDS Stops Treatment with Combination Antiplatelet Therapy (Clopidogrel plus Aspirin) Due to Higher Risk of Major Hemorrhage and Death
- National Institute of Neurological Disorders and Stroke (NINDS)
- September 19, 2011
- NCI Issues Clinical Announcement for Preferred Method of Treatment for Advanced Ovarian Cancer
- National Cancer Institute (NCI)
- January 4, 2006
- Important Interim Results from a Phase III, Randomized, Double-Blind Comparison of Three Protease-Inhibitor-Sparing Regimens for the Initial Treatment of HIV Infection (AACTG Protocol A5095)
- National Institute of Allergy and Infectious Diseases (NIAID)
- March 13, 2003
- Women with Rare Lung Disease Found to Also Have High Prevalence of Meningiomas, First Study to Document Tumor Connection; Possible Hormonal Cause
- National Heart, Lung, and Blood Institute (NHLBI)
- October 18, 2001
- Antioxidant Vitamins and Zinc Reduce Risk of Vision Loss from Age-Related Macular Degeneration
Same Nutrients Have No Effect on the Development of Cataract - National Eye Institute (NEI)
- October 15, 2001
- NIDCD/VA Clinical Trial Finding Can Benefit Millions with Hearing Loss
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- October 10, 2000
- Treating Hypertension in the Patient with Type 2 Diabetes
- National Heart, Lung, and Blood Institute (NHLBI)
- May 30, 2000
- NHLBI Issues New Clinical Advisory on Systolic Blood Pressure
- National Heart, Lung, and Blood Institute (NHLBI)
- May 4, 2000
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