Drugs
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Cytochrome P450 2D6
Aklillu E et al. J Pharmacol Exp Ther 1996;278(1):441– 446
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Absent in 7% of Caucasians, 1–2% non-Caucasians
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Hyperactive in up to 30% of East Africans
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Catalyzes primary metabolism of:
- Codeine
- Many ?-blockers
- Many tricyclic antidepressants
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Inhibited by:
- Fluoxetine
- Haloperidol
- Paroxetine
- Quinidine
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