Resources for Researchers : Urological Diseases
- Urological Diseases Databases, Registries and Information
- Urological Diseases Multicenter Clinical Research
- Urological Diseases Basic Research Networks
- Urological Diseases Reagents
- Urological Diseases Services
- Urological Diseases Standardization Programs
- Urological Diseases Tissues, Cells, Animals
- Urological Diseases Useful Tools
back to top
|
Central NIDDK Repository for Biosamples and Data
http://www.niddkrepository.org On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.
For more information, contact Dr. Rebekah Rasooly, KUH, Program Director, Genetics and Genomics; Basic PKD.
|
Murine Atlas of Genitourinary Development (GUDMAP)
http://www.gudmap.org/ The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is a consortium of laboratories working to provide the scientific and medical community with tools to facilitate research. The key components are: - a molecular atlas of gene expression for the developing organs of the GenitoUrinary (GU) tract
- a high resolution molecular anatomy that highlights development of the GU system
- mouse strains to facilitate developmental and functional studies within the GU system
- tutorials describing GU organogenesis
- rapid access to primary data via the GUDMAP database
For more information, contact Dr. Deborah Hoshizaki, KUH, Program Director, Kidney and Urogenital Development; Kidney and Urology Regeneration and Repair; Urology Centers.
|
National Gene Vector Laboratories (NGVL)
http://www.ngvl.org/ The National Gene Vector Laboratories (NGVL) are composed of an interactive group of academic production and pharm/tox laboratories whose primary goal is to provide eligible investigators with clinical grade vectors for phase I/II gene therapy clinical trials and to provide support for relevant pharmacology/toxicology studies leading up to clinical gene transfer protocols. If the application is approved, clinical grade material will be produced at no cost to the investigator.
For more information, contact Dr. Catherine McKeon, DEM, Senior Advisor for Genetic Research in Diabetes, Endocrinology and Metabolic Diseases.
|
National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC)
http://kidney.niddk.nih.gov or http://www.urologic.niddk.nih.gov The kidney and urologic diseases clearinghouse provides comprehensive information about bladder and renal health and disease for the public: online, in booklets and fact sheets, by email, and over the phone.
For more information, contact Ms. Kathy Kranzfelder, OCPL, Director, NIDDK Information Clearinghouses.
|
Urologic Diseases in America Compendium (UDA)
http://kidney.niddk.nih.gov/statistics/uda/ Urologic diseases cover a wide range of conditions, symptoms, and problems that include such diverse diagnoses as cancer, pelvic pain, sexual dysfunction, urinary incontinence, kidney stones, and benign prostatic hyperplasia (BPH). To remedy this lack of information, NIDDK initiated the Urologic Disease in America (UDA) project. The UDA compendium delineates the changes in the epidemiology, health economic impact, and practice patterns for the diseases currently included within the scope of practice of the specialty of urology, analyzed retrospectively over a ten-year period. The UDA compendium consists of data tables annotated in chapters that amplify the data analyses. The objectives of the UDA project include secondary data analyses of the following topics: (1) changes in the overall health care burden for individual urologic diseases; (2) changes in physician practice patterns for each urologic disease; (3) changes in demographics of persons with urologic disease; (4) the impact of specific urologic diseases, especially diseases of the prostate, on the minority populations of the U.S.; (5) documentation of new and evolving therapies for urologic disease and their potential impact on treatment outcomes and health care costs. The resultant compendium can be found at the above web address. In addition to updating the original compendium, the second phase of the UDA is to focus less on descriptive analyses and more on analytical outcomes analyses, and it will also attempt to increase involvement of the urologic community in analytical activities.
For more information, contact Dr. Paul Eggers, KUH, Program Director, Epidemiology and U.S. Renal Data System; End-Stage Renal Disease.
|
back to top
|
Behavior Enhances Drug Reduction of Incontinence (BE-DRI)
http://www.uitn.net/ This study by the Urinary Incontinence Treatment Network (UITN) will determine if the addition of behavioral treatment to drug therapy for the treatment of urge incontinence will make it possible to discontinue the drug and still maintain a reduced number of accidents. The most popular treatments for urge incontinence are drug therapy and behavior therapy, each with its own limitations. In this clinical study, the UITN aims to determine differences with the addition of behavioral treatment to drug therapy alone.
|
Boston Area Community Health (BACH) Survey
http://www.niddkrepository.org ![EXIT Disclaimer](https://webarchive.library.unt.edu/web/20121002030108im_/http://www2.niddk.nih.gov/NR/rdonlyres/5017C85D-83EB-455D-82A4-62757DD6C7E0/0/exit_small.gif) The Boston Area Community Health (BACH) Survey is an epidemiologic study being conducted in the Boston metropolitan area to examine the prevalence of symptoms for health problems such as interstitial cystitis, urinary incontinence, benign prostatic hyperplasia, prostatitis, hypogonadism, and sexual function. Of interest to the survey are health disparities and inequalities. BACH is especially concerned with lack of adequate health insurance, lack of access to adequate medical care, and how these problems influence patterns of disease. The study also focuses on social determinants of disease that are over and above the contribution of individual characteristics and risk factors. To achieve a randomly sampled population, four neighborhoods were divided into 12 strata and from them investigators selected census blocks. Households were then randomly selected from the census blocks and sampled to identify eligible study participants. BACH data is available through the NIDDK Central Repositories (www.niddkrepository.org).
For more information, contact Dr. Paul Eggers, KUH, Program Director, Epidemiology and U.S. Renal Data System; End-Stage Renal Disease, or Dr. John Kusek, KUH, Program Director, Kidney and Urology Clinical Trials.
|
Chronic Prostatitis Collaborative Research Network Alpha Blocker Trial
http://porter.cceb.upenn.edu:7778/servlet/page?_pageid=243,245&_dad=portal30&_schema=PORTAL30 The purpose of this randomized clinical trial is to evaluate the efficacy and safety of the alpha adrenergic blocker Alfuzosin (Uroxatral) in men with relatively new onset of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
For more information, contact Dr. John Kusek, KUH, Program Director, Kidney and Urology Clinical Trials.
|
Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Clinical Trial
http://www.camus.uab.edu/camus/html/index.htm The Complementary and Alternative Medicine for Urological Symptoms (CAMUS) is a randomized, placebo controlled trial of phytotherapy for benign prostate symptoms among men.
For more information, contact Dr. John Kusek, KUH, Program Director, Kidney and Urology Clinical Trials.
|
|
|
Maryland Genetics of Interstitial Cystitis (MaGIC)
The MaGIC study investigated several hundred families with two or more blood relatives with interstitial cystitis in order to understand the molecular genetic basis of this condition.
For more information, contact Dr. Rebekah Rasooly, KUH, Program Director, Genetics and Genomics; Basic PKD.
|
Minimally Invasive Surgical Therapies (MIST) Treatment Consortium for Benign Prostatic Hyperplasia (BPH)
The primary objective of this randomized clinical trial is to determine the efficacy and safety of three treatments for benign prostatic hyperplasia (BPH): transurethral needle ablation (TUNA), transurethral microwave therapy (TUMT), and medical therapy with alfuzosin and finasteride.
For more information, contact Dr. John Kusek, KUH, Program Director, Kidney and Urology Clinical Trials.
|
Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network is designed to conduct collaborative studies of urologic chronic pelvic pain disorders by looking for clues outside the bladder and prostate. The MAPP Research Network includes six Discovery Sites that conduct research studies and two Core Sites that coordinate data collection, analyze tissue samples, and provide technical support. This initiative is unique and includes novel approaches and highly collaborative research on the two most prominent urologic chronic pelvic pain disorders, interstitial cystitis/painful bladder syndrome (IC/PBS), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The MAPP Network represents a major shift in research direction from the traditional organ-specific view to a broadened systemic perspective of disease.
Scientists at the Discovery Sites conduct individual and collaborative multi-site research projects, supported by the network Core Sites. An important step in these studies is the careful and extensive phenotyping (clinical characterization) of the men and women participating in the studies. The Data Coordination Core provides overall administration and coordination of multi-site research studies and perform data analyses. The Tissue Analysis and Technology Core banks, analyzes, and distributes DNA, serum and urine samples. Tissue analyses will help in the search for biomarkers, important in screening for diseases and for monitoring treatment outcomes. The Tissue Analysis and Technology Core Site also performs genomic and proteomic tissue expression analyses. It is hoped that collectively these efforts will lead to new treatment approaches, identify risk factors, and help predict which patients may respond to various interventions. For additional information, visit the MAPP Network website at: http://www.mappnetwork.org.
For more information, contact Dr. Chris Mullins, KUH, Program Director, Urology Basic Cell Biology; Urology Small Business.
|
Program to Reduce Incontinence by Diet and Exercise (PRIDE)
PRIDE (Program to Reduce Incontinence by Diet and Exercise) is an exciting new research study to learn more about the effects of weight loss on urinary incontinence. About 330 overweight women aged 30 or older will participate in this randomized controlled trial. PRIDE is being conducted at two clinical centers in the United States and is coordinated by the Women's Health Clinical Research Center at the University of California, San Francisco.
For more information, contact Dr. John Kusek, KUH, Program Director, Kidney and Urology Clinical Trials.
|
Randomized Intervention for Vesicoureteral Reflux (RIVUR)
http://www.rivur.net The multicenter, randomized, double-blind, placebo-controlled RIVUR trial is designed to determine whether daily antimicrobial prophylaxis is superior to placebo in preventing recurrence of UTI in children with VUR. The basic eligibility criteria are: (1) age at randomization of at least 2 months, but less than 6 years, (2) a diagnosed first febrile or symptomatic UTI within 42 days prior to randomization that was appropriately treated, and (3) presence of Grade I-IV VUR based on voiding cystourethrogram (VCUG). Patients will be randomly assigned to treatment for 2 years with daily antimicrobial prophylaxis (trimethoprim-sulfamethoxazole) or placebo. The study is designed to recruit 600 children (approximately 300 in each treatment group) over an 18-24 month period. The primary endpoint is recurrence of UTI. In addition, patients will be evaluated for secondary endpoints related to renal scarring and antimicrobial resistance. Scarring will be determined based on renal scintigraphy by 99mTc dimercaptosuccinic (DMSA) scan. Quality of life, compliance, safety parameters, utilization of health resources, and change in VUR will be assessed periodically throughout the study.
For more information, contact Dr. Marva Moxey-Mims, Deputy Director, KUH Clinical Science and Program Director, Pediatric Nephrology and Urology; Kidney Centers; Kidney Small Business
|
Stress Incontinence Surgical Treatment Efficacy Trial (SISTEr)
http://www.uitn.net/ The primary aim of this clinical trial under the UITN is to compare the treatment success for two surgical procedures that are frequently used and have similar cure rates, yet have not been compared directly to each other in a large, rigorously conducted randomized trial. The secondary aims of the trial are to compare other outcomes for the two surgical procedures, including quality of life, sexual function, satisfaction with treatment outcomes, complications, and need for other treatment(s)after surgery. Follow-up will be a minimum of two years and up to four years.
|
Swedish Twin Registry Study of Interstitial Cystitis
This project investigated the etiology of interstitial cystitis (IC) using multivariate data from a large population-based classical twin study in the population-based Swedish Twin Registry (STR). This study is part of the Interstitial Cystitis Genetics Consortium. The other part is the Maryland Genetics of Interstitial Cystitis (MaGIC) study (see above).
For more information, contact Dr. Rebekah Rasooly, KUH, Program Director, Genetics and Genomics; Basic PKD.
|
Trial of Mid-Urethral Slings (TOMUS)
http://www.uitn.net/ In this clinical trial, the Urinary Incontinence Treatment Network (UITN) aims to compare two surgical approaches of minimally invasive procedures for the treatment of stress urinary incontinence.
For more information, contact Dr. John Kusek, KUH, Program Director, Kidney and Urology Clinical Trials.
|
Urinary Incontinence Treatment Network (UITN)
http://www.niddk.nih.gov/patient/uitn/uitn.htm or http://www.uitn.net/ The network is a group of collaborating investigators who conduct long-term studies and clinical trials of the most commonly used surgical, pharmacological, and behavioral approaches for management of urinary incontinence in women diagnosed with stress and mixed incontinence.
|
Urological Pelvic Pain Collaborative Research Network (UPPCRN)
http://porter.cceb.upenn.edu:7778/servlet/page?_pageid=389,391,400&_dad=portal30&_schema=PORTAL30 The UPPCRN is the overarching organization for collaborative research in chronic prostatitis, chronic pelvic pain syndrome, and interstitial cystitis. It serves as the official NIDDK Working Group on chronic pelvic pain of urological origin, to facilitate interaction of study groups and investigators, both nationally and internationally, to advance our understanding, diagnosis, and treatment of these diseases.
For more information, contact Dr. John Kusek, KUH, Program Director, Kidney and Urology Clinical Trials.
|
back to top
|
Animal Models of Diabetic Complications Consortium (AMDCC)
www.amdcc.org The AMDCC is an interdisciplinary consortium designed to develop animal models that closely mimic the human complications of diabetes for the purpose of studying disease pathogenesis, prevention and treatment. The consortium consists of thirteen “pathobiology sites” that study complications such as diabetic nephropathy, uropathy, neuropathy, cardiomyopathy and vascular disease. Additional goals of the AMDCC are to define standards to validate each diabetic complication for its similarity to the human disease, test the role of candidate genes that emerge from human genetic studies, and facilitate the exchange of animals, reagents, and expertise between members of the consortium and the greater scientific community. To ensure that all mice generated under the auspices of the AMDCC are phenotyped for a full duration of diabetes and across all relevant complications, the consortium has formed a close partnership with the NIDDK-funded Mouse Metabolic Phenotyping Centers (MMPCs). The MMPCs (www.mmpc.org) conduct detailed metabolic phenotyping of genetically altered mice and other mouse models that are useful for understanding diabetes and its complications, obesity, and related metabolic diseases or conditions.
For more information, contact Dr. Chris Ketchum, Deputy Director, KUH Basic Science and Program Director, Kidney Basic Physiology.
|
Central NIDDK Repository for Biosamples and Data
http://www.niddkrepository.org On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.
For more information, contact Dr. Rebekah Rasooly, KUH, Program Director, Genetics and Genomics; Basic PKD.
|
Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network is designed to conduct collaborative studies of urologic chronic pelvic pain disorders by looking for clues outside the bladder and prostate. The MAPP Research Network includes six Discovery Sites that conduct research studies and two Core Sites that coordinate data collection, analyze tissue samples, and provide technical support. This initiative is unique and includes novel approaches and highly collaborative research on the two most prominent urologic chronic pelvic pain disorders, interstitial cystitis/painful bladder syndrome (IC/PBS), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The MAPP Network represents a major shift in research direction from the traditional organ-specific view to a broadened systemic perspective of disease.
Scientists at the Discovery Sites conduct individual and collaborative multi-site research projects, supported by the network Core Sites. An important step in these studies is the careful and extensive phenotyping (clinical characterization) of the men and women participating in the studies. The Data Coordination Core provides overall administration and coordination of multi-site research studies and perform data analyses. The Tissue Analysis and Technology Core banks, analyzes, and distributes DNA, serum and urine samples. Tissue analyses will help in the search for biomarkers, important in screening for diseases and for monitoring treatment outcomes. The Tissue Analysis and Technology Core Site also performs genomic and proteomic tissue expression analyses. It is hoped that collectively these efforts will lead to new treatment approaches, identify risk factors, and help predict which patients may respond to various interventions. For additional information, visit the MAPP Network website at: http://www.mappnetwork.org.
For more information, contact Dr. Chris Mullins, KUH, Program Director, Urology Basic Cell Biology; Urology Small Business.
|
Network of Minority Research Investigators (NMRI)
http://nmri.niddk.nih.gov/ NMRI is a communication network of current and potential biomedical research investigators and technical personnel from traditionally under-served communities: African American, Hispanic American, American Indian, Alaskan Native, Native Hawaiian, and other Pacific Islanders. The major objective of the network is to encourage and facilitate participation of members of underrepresented racial and ethnic minority groups in the conduct of biomedical research in the fields of diabetes, endocrinology, metabolism, digestive diseases, nutrition, kidney, urologic and hematologic diseases. A second objective is to encourage and enhance the potential of the underrepresented minority investigators in choosing a biomedical research career in these fields. An important component of this network is promotion of two-way communications between network members and the NIDDK.
For more information, contact Ms. Winnie Martinez, Program Analyst, Office of Minority Health Research Coordination.
|
Urological Diseases Reagents back to top
|
Central NIDDK Repository for Biosamples and Data
http://www.niddkrepository.org On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.
For more information, contact Dr. Rebekah Rasooly, KUH, Program Director, Genetics and Genomics; Basic PKD.
|
National Gene Vector Laboratories (NGVL)
http://www.ngvl.org/ The National Gene Vector Laboratories (NGVL) are composed of an interactive group of academic production and pharm/tox laboratories whose primary goal is to provide eligible investigators with clinical grade vectors for phase I/II gene therapy clinical trials and to provide support for relevant pharmacology/toxicology studies leading up to clinical gene transfer protocols. If the application is approved, clinical grade material will be produced at no cost to the investigator.
For more information, contact Dr. Catherine McKeon, DEM, Senior Advisor for Genetic Research in Diabetes, Endocrinology and Metabolic Diseases.
Zebrafish Gene Collection (ZGC)
http://zgc.nci.nih.gov/ The Zebrafish Gene Collection (ZGC) was an NIH initiative that supported the production of cDNA libraries, clones and sequences to provide a complete set of full-length (open reading frame) sequences and cDNA clones of expressed genes for zebrafish. All resources generated by the ZGC are publicly accessible to the biomedical research community. For an overview, see the ZGC Project Summary. Project Officer (NIDDK): Rebekah S. Rasooly, Ph.D., 301-594-6007.
|
Urological Diseases Services back to top
|
Center for Inherited Disease Research (CIDR)
http://www.cidr.jhmi.edu A centralized facility established to provide genotyping and statistical genetics services for investigators seeking to identify genes that contribute to human disease. CIDR concentrates primarily on multifactorial hereditary disease although linage analysis of single gene disorders can also be accommodated.
For more information, contact Dr. Catherine McKeon, DEM, Senior Advisor for Genetic Research in Diabetes, Endocrinology and Metabolic Diseases.
|
Central NIDDK Repository for Biosamples and Data
http://www.niddkrepository.org On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.
For more information, contact Dr. Rebekah Rasooly, KUH, Program Director, Genetics and Genomics; Basic PKD.
|
Rapid Access to Intervention Development (NIH RAID)
http://nihroadmap.nih.gov/raid/ NIH RAID provides a variety of contract services researchers need to bring promising potential therapeutics to trial.
|
back to top
|
There are none at this time. Please check back.
|
back to top
|
Animal Models of Diabetic Complications Consortium (AMDCC)
www.amdcc.org The AMDCC is an interdisciplinary consortium designed to develop animal models that closely mimic the human complications of diabetes for the purpose of studying disease pathogenesis, prevention and treatment. The consortium consists of thirteen “pathobiology sites” that study complications such as diabetic nephropathy, uropathy, neuropathy, cardiomyopathy and vascular disease. Additional goals of the AMDCC are to define standards to validate each diabetic complication for its similarity to the human disease, test the role of candidate genes that emerge from human genetic studies, and facilitate the exchange of animals, reagents, and expertise between members of the consortium and the greater scientific community. To ensure that all mice generated under the auspices of the AMDCC are phenotyped for a full duration of diabetes and across all relevant complications, the consortium has formed a close partnership with the NIDDK-funded Mouse Metabolic Phenotyping Centers (MMPCs). The MMPCs (www.mmpc.org) conduct detailed metabolic phenotyping of genetically altered mice and other mouse models that are useful for understanding diabetes and its complications, obesity, and related metabolic diseases or conditions.
For more information, contact Dr. Chris Ketchum, Deputy Director, KUH Basic Science and Program Director, Kidney Basic Physiology.
|
Central NIDDK Repository for Biosamples and Data
http://www.niddkrepository.org On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.
For more information, contact Dr. Rebekah Rasooly, KUH, Program Director, Genetics and Genomics; Basic PKD.
|
|
Mutant Mouse Regional Resource Centers (MMRRC)
http://www.mmrrc.org/ The goal of the MMRRC program is to enhance the availability of and help ensure the quality of genetically modified mice for biomedical research of human and animal biology and disease.
For more information, contact Dr. Kristin Abraham, DEM, Director, Cell Signaling and Diabetes Centers Program.
|
Type 1 Diabetes Mouse Repository at Jackson Laboratory (T1DR)
http://www.jax.org/t1dr/ NIDDK has funded a Type 1 Diabetes Resource (T1DR) at The Jackson Laboratory (TJL). The purpose of this resource is to collect and cryopreserve ~150 mouse stocks important to research in type 1 diabetes.
For more information, contact Dr. Kristin Abraham, DEM, Director, Cell Signaling and Diabetes Centers Program.
Zebrafish Gene Collection (ZGC)
http://zgc.nci.nih.gov/
The Zebrafish Gene Collection (ZGC) was an NIH initiative that supported the production of cDNA libraries, clones and sequences to provide a complete set of full-length (open reading frame) sequences and cDNA clones of expressed genes for zebrafish. All resources generated by the ZGC are publicly accessible to the biomedical research community. For an overview, see the ZGC Project Summary. Project Officer (NIDDK): Rebekah S. Rasooly, Ph.D., 301-594-6007.
|
back to top
|
Chronic Prostatitis Symptom Index (CPSI):
http://www.prostatitis.org/symptomindex.html ![EXIT Disclaimer](https://webarchive.library.unt.edu/web/20121002030108im_/http://www2.niddk.nih.gov/NR/rdonlyres/5017C85D-83EB-455D-82A4-62757DD6C7E0/0/exit_small.gif)
A questionnaire developed in 1999 by physicians in NIDDK's Chronic Prostatitis Collaborative Research Network can help physicians to accurately measure the severity of prostatitis symptoms and their impact on a patient's lifestyle. The CPSI questionnaire assesses pain, urination, and the effect of chronic prostatitis on daily activities. With this information, researchers and physicians can reliably evaluate whether potential treatments are working. The questionnaire was originally published in the Journal of Urology in August 1999 (Vol. 162, pages 369-375). It is available as a PDF document in English, Spanish, German and Korean.
|
Symptom Score for Benign Prostatic Hyperplasia
http://www.niddk.nih.gov/fund/divisions/kuh/useful-tools/AUA-BPH.pdf Adapted from the American Urology Association's Symptom Score for BPH, this chart will assist physicians, researchers, and patients in assessing the severity of the problem.
|
* Documents in PDF format require the free Adobe Acrobat Reader
application for viewing.
Page last updated: March 24, 2011