The search textbox has an autosuggest feature. When you enter three or more characters,
a list of up to 10 suggestions will popup under the textbox. Use the arrow keys
to move through the suggestions. To select a suggestion, hit the enter key. Using
the escape key closes the listbox and puts you back at the textbox. The radio buttons
allow you to toggle between having all search items start with or contain the text
you entered in the search box.
procarbazine hydrochloride
The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | Ibenzmethyzin ibenzmethyzin hydrochloride ibenzmethyzine hydrochloride MIH MIH hydrochloride PCB Hydrochloride PCZ Procarbazin | |
| |||
| US brand name: | | Matulane | |
| |||
| Foreign brand names: | | Natulan Natulanar Natunalar | |
| |||
| Abbreviations: | | PCB PCZ | |
| |||
| Code names: | | NCI-C01810 Ro 4-6467/1 | |
| |||
| Chemical structures: | | benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine hydrochloride N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride N-methylhydrazine p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI) | |
| |||
