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vemurafenib
An orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of
Synonym: | BRAF(V600E) kinase inhibitor RO5185426 | ||
US brand name: | Zelboraf | ||
Code names: | PLX4032 RG7204 RO5185426 | ||