Skip navigation

Garlic


What is it?

Garlic is an herb. It is best known as a flavoring for food. But over the years, garlic has been used as a medicine to prevent or treat a wide range of diseases and conditions. The fresh clove or supplements made from the clove are used for medicine.

Garlic is used for many conditions related to the heart and blood system. These conditions include high blood pressure, high cholesterol, coronary heart disease, heart attack, and “hardening of the arteries” (atherosclerosis). Some of these uses are supported by science. Garlic actually may be effective in slowing the development of atherosclerosis and seems to be able to modestly reduce blood pressure.

Some people use garlic to prevent colon cancer, rectal cancer, stomach cancer, breast cancer, prostate cancer, and lung cancer. It is also used to treat prostate cancer and bladder cancer.

Garlic has been tried for treating an enlarged prostate (benign prostatic hyperplasia; BPH), diabetes, osteoarthritis, hayfever (allergic rhinitis), traveler's diarrhea, high blood pressure late in pregnancy (pre-eclampsia), cold and flu. It is also used for building the immune system, preventing tick bites, and preventing and treating bacterial and fungal infections.

Other uses include treatment of fever, coughs, headache, stomach ache, sinus congestion, gout, rheumatism, hemorrhoids, asthma, bronchitis, shortness of breath, low blood pressure, low blood sugar, high blood sugar, and snakebites. It is also used for fighting stress and fatigue, and maintaining healthy liver function.

Some people apply garlic oil to their skin to treat fungal infections, warts, and corns. There is some evidence supporting the topical use of garlic for fungal infections like ringworm, jock itch, and athlete’s foot; but the effectiveness of garlic against warts and corns is still uncertain.

There is a lot of variation among garlic products sold for medicinal purposes. The amount of allicin, the active ingredient and the source of garlic’s distinctive odor, depends on the method of preparation. Allicin is unstable, and changes into a different chemical rather quickly. Some manufacturers take advantage of this by aging garlic to make it odorless. Unfortunately, this also reduces the amount of allicin and compromises the effectiveness of the product. Some odorless garlic preparations and products may contain very little, if any, allicin. Methods that involve crushing the fresh clove release more allicin. Some products have a coating (enteric coating) to protect them against attack by stomach acids.

While garlic is a common flavoring in food, some scientists have suggested that it might have a role as a food additive to prevent food poisoning. There is some evidence that fresh garlic, but not aged garlic, can kill certain bacteria such as E. coli, antibiotic-resistant Staphylococcus aureus, and Salmonella enteritidis in the laboratory.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for GARLIC are as follows:

Possibly effective for...

  • High blood pressure. Some research shows that garlic can reduce blood pressure in people with high blood pressure by as much as 7% or 8%. It also seems to lower blood pressure in people with normal blood pressure. Most studies have used a specific garlic powder product (Kwai, from Lichtwer Pharma).
  • “Hardening of the arteries” (atherosclerosis). As people age, their arteries tend to lose their ability to stretch and flex with age. Garlic seems to reduce this effect.
  • Colon cancer, rectal cancer, and stomach cancer. Eating garlic seems to reduce the risk of developing these cancers. However, garlic supplements don’t seem to offer the same benefit.
  • Tick bites. Scientists have compared the number of tick bites in people who take high doses of garlic compared to people who do not take garlic. High doses of dietary garlic, over about a five-month period, seem to reduce the number of tick bites.
  • Fungal infections of the skin (including ringworm, jock itch and athlete’s foot). Ringworm and jock itch respond to treatment with a garlic gel containing 0.6% ajoene (a chemical in garlic) that is applied to the skin. A garlic gel with a higher concentration of ajoene (1%) is needed to be effective against athlete’s foot. In fact, garlic gel with 1% ajoene seems to be about as effective against athlete’s foot as the medicine Lamisil.

Possibly ineffective for...

  • Diabetes. Taking garlic doesn’t seem to have any effect on blood sugar, either in people with diabetes or those without it.
  • Treating bacteria called helicobacter pylori (H. pylori) that can cause ulcers. Taking garlic by mouth for H. pylori infection used to look promising due to laboratory evidence showing potential activity against H. pylori. However, when garlic cloves, powder, or oil is used in humans, it doesn't seem to have any beneficial effect for treating people infected with H. pylori.
  • High cholesterol. Lots of studies — some better than others — have been done to measure the effectiveness of garlic in lowering cholesterol and another type of fat called triglycerides. The results have been conflicting. However, if only the high quality studies are considered, reviewers conclude that garlic does not significantly lower cholesterol or triglyceride levels.
  • Breast cancer. Taking garlic does not seem to reduce the risk of getting breast cancer.
  • Lung cancer. Taking garlic does not seem to reduce the risk of getting lung cancer.
  • Leg pain when walking due to poor blood circulation in the legs (peripheral arterial disease or PAD). Taking garlic, even for 12 weeks, does not seem to help people with this condition.

Insufficient evidence to rate effectiveness for...

  • Benign prostatic hyperplasia (BPH). There is some preliminary evidence that taking garlic by mouth might be helpful for improving urinary flow, decreasing urinary frequency, and other symptoms associated with BPH.
  • Common cold. Preliminary research suggests garlic might reduce the frequency and number of colds when taken for prevention.
  • Corns. Early studies suggest that applying certain garlic extracts to corns on the feet twice daily improves corns. One particular garlic extract that dissolves in fat has an effect after 10-20 days of treatment, but a water soluble extract can take up to two months to show improvement.
  • High blood pressure in pregnancy (pre-eclampsia). Some preliminary clinical evidence suggests that taking a specific garlic extract (Garlet) 800 mg/day during the third trimester of pregnancy does not reduce the risk of developing pre-eclampsia in high-risk women.
  • Prostate cancer. Men in China who eat about a clove of garlic daily seem to have a 50% lower risk of developing prostate cancer. Whether this benefit applies to men in Western countries is not known.
  • Warts. Preliminary evidence suggests that applying a specific fat soluble garlic to warts on the hands twice daily removes warts within 1-2 weeks. A water-soluble garlic extract also seems to provide modest improvement, but only after 30-40 days of treatment.
More evidence is needed to rate garlic for these uses.

How does it work?

Return to top
Garlic produces a chemical called allicin. This is what seems to make garlic work for certain conditions. Allicin also makes garlic smell. Some products are made “odorless” by aging the garlic, but this process can also make the garlic less effective. It’s a good idea to look for supplements that are coated (enteric coating) so they will dissolve in the intestine and not in the stomach.

Are there safety concerns?

Return to top
Garlic is LIKELY SAFE for most people when taken by mouth. Garlic can cause bad breath, a burning sensation in the mouth or stomach, heartburn, gas, nausea, vomiting, body odor, and diarrhea. These side effects are often worse with raw garlic. Garlic may also increase the risk of bleeding. There have been reports of bleeding after surgery in people who have taken garlic. Asthma has been reported in people working with garlic, and other allergic reactions are possible.

When used on the skin, garlic is POSSIBLY UNSAFE. Using as a thick paste (poultice), garlic can cause damage to the skin that is similar to a burn.

Special precautions & warnings:

Pregnancy and breast-feeding: Garlic is LIKELY SAFE in pregnancy when taken in the amounts normally found in food. Garlic is POSSIBLY UNSAFE when used in medicinal amounts in pregnancy and breast-feeding. There isn’t enough reliable information about the safety of using garlic on the skin if you are pregnant or breast-feeding. Stay on the safe side, and avoid use.

Children: Garlic is POSSIBLY SAFE when taken by mouth and appropriately for a short-term in children. But garlic is POSSIBLY UNSAFE when taken by mouth in large doses. Some sources suggest that high doses of garlic could be dangerous or even fatal to children; however, the reason for this warning is not known. There are no case reports available of significant adverse events or mortality in children associated with taking garlic by mouth.

Bleeding disorder: Garlic, especially fresh garlic, might increase bleeding.

Stomach or digestion problems: Garlic can irritate the gastrointestinal (GI) tract. Use with caution if you have stomach or digestion problems.

Surgery: Garlic might prolong bleeding. Stop taking garlic at least two weeks before a scheduled surgery.

Are there interactions with medications?

Return to top

Major

Do not take this combination.

Isoniazid (INH, Nydrazid)
Garlic might reduce how much isoniazid (Nydrazid, INH) the body absorbs. This might decrease how well isoniazid (Nydrazid, INH) works. Don't take garlic if you take isoniazid (Nydrazid, INH).

Medications used for HIV/AIDS (Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs))
The body breaks down medications used for HIV/AIDS to get rid of them. Garlic can increase how fast the body breaks down some medications for HIV/AIDS. Taking garlic along with some medications used for HIV/AIDS might decrease their effectiveness.

Some of these medications used for HIV/AIDS include nevirapine (Viramune), delavirdine (Rescriptor), and efavirenz (Sustiva).

Saquinavir (Fortovase, Invirase)
The body breaks down saquinavir (Fortovase, Invirase) to get rid of it. Garlic might increase how quickly the body breaks down saquinavir. Taking garlic along with saquinavir (Fortovase, Invirase) might decrease the effectiveness of saquinavir (Fortovase, Invirase).

Moderate

Be cautious with this combination.

Birth control pills (Contraceptive drugs)
Some birth control pills contain estrogen. The body breaks down the estrogen in birth control pills to get rid of it. Garlic might increase the breakdown of estrogen. Taking garlic along with birth control pills might decrease the effectiveness of birth control pills. If you take birth control pills along with garlic, use an additional form of birth control such as a condom.

Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.

Cyclosporine (Neoral, Sandimmune)
The affect of garlic preparations on cyclosporine may vary. Some garlic preparations containing allicin might decrease the effectiveness of cyclosporine. However, other garlic preparations containing alliin and alliinase may not. Until more is known about this possible interaction, don't take garlic if you are taking cyclosporine.

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates)
Some medications are changed and broken down by the liver. Garlic oil might decrease how quickly the liver breaks down some medications. Taking garlic oil along with some medications that are changed by the liver can increase the effects and side effects of your medication. Before taking garlic oil, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and drugs used for anesthesia during surgery such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane).

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Some medications are changed and broken down by the liver. Garlic might increase how quickly the liver breaks down some medications. Taking garlic along with some medications that are broken down by the liver can decrease the effectiveness of some medications. Before taking garlic, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Medications that might be affected include certain heart medications called calcium channel blockers (diltiazem, nicardipine, verapamil), cancer drugs (etoposide, paclitaxel, vinblastine, vincristine, vindesine), fungus-fighting drugs (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), midazolam (Versed), and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Garlic might slow blood clotting. Taking garlic along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Warfarin (Coumadin)
Warfarin (Coumadin) is used to slow blood clotting. Garlic might increase the effectiveness of warfarin (Coumadin). Taking garlic along with warfarin (Coumadin) might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Are there interactions with herbs and supplements?

Return to top
Fish oil (containing eicosapentaenoic acid (EPA))
Fish oil can slow blood clotting. Garlic can also slow clotting. Taken together, garlic and fish oil may increase the risk of bleeding in some people.

Herbs and supplements that might slow blood clotting
Using garlic with other herbs that can slow blood clotting might increase the risk of bleeding in some people. These other herbs include angelica, clove, danshen, ginger, ginkgo, red clover, turmeric, vitamin E, willow, and others.

Are there interactions with foods?

Return to top
There are no known interactions with foods.

What dose is used?

Return to top
The following doses have been studied in scientific research:

BY MOUTH:
  • For high blood pressure:
    • Garlic extract 600-1200 mg divided and given three times daily.
    • Standardized garlic powder extract containing 1.3% alliin content has been studied for this use.
    • Aged garlic extract 600 mg to 7.2 grams per day has also been used. Aged garlic typically contains only 0.03% alliin.
    • Fresh garlic 4 grams (approximately one clove) once daily has also been used. Fresh garlic typically contains 1% alliin.
  • For prevention of colon, rectal, and stomach cancer: fresh or cooked garlic 3.5-29 grams weekly.
APPLIED TO THE SKIN:
  • For fungal skin infections (ringworm, jock itch, athlete’s foot): garlic ingredient ajoene as a 0.4% cream, 0.6% gel, and 1% gel applied twice daily for one week.

Other names

Return to top
Aged Garlic Extract, Ail, Ajo, Allii Sativi Bulbus, Allium, Allium sativum, Camphor of the Poor, Clove Garlic, Da Suan, Garlic Clove, Garlic Oil, Lasun, Lasuna, Nectar of the Gods, Poor Man’s Treacle, Rason, Rust Treacle, Stinking Rose.

Methodology

Return to top
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.methodology (http://www.nlm.nih.gov/medlineplus/druginfo/natural/methodology.html).

References

Return to top
To see all references for the Garlic page, please go to http://www.nlm.nih.gov/medlineplus/druginfo/natural/300.html.

  1. Cox MC, Low J, Lee J, et al. Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel. Clin Cancer Res 2006;12:4636-40.
  2. Ried K, Frank OR, Stocks NP, et al. Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord 2008;8:13.
  3. Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700.
  4. Cavagnaro PF, Camargo A, Galmarini CR, Simon PW. Effect of cooking on garlic (Allium sativum l.) Antiplatelet activity and thiosulfinates content. J Agric Food Chem 2007;55:1280-8.
  5. Satitvipawee P, Rawdaree P, Indrabhakti S, et al. No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic subjects. J Med Assoc Thai 2003;86:750-7.
  6. Gardner CD, Lawson LD, Block E, et al. Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. Arch Intern Med 2007;167:346-53.
  7. Hubbard VG, Goldsmith P. Garlic-fingered chefs. Contact Dermatitis 2005;52:165-6.
  8. Macan H, Uykimpang R, Alconcel M, et al. Aged garlic extract may be safe for patients on warfarin therapy. J Nutr 2006;136(3 Suppl):793S-795S.
  9. Dhamija P, Malhotra S, Pandhi P. Effect of oral administration of crude aqueous extract of garlic on pharmacokinetic parameters of isoniazid and rifampicin in rabbits. Pharmacology 2006;77:100-4.
  10. Dehghani F, Merat A, Panjehshahin MR, Handjani F. Healing effect of garlic extract on warts and corns. Int J Dermatol 2005;44:612-5.
  1. Meher S, Duley L. Garlic for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2006;3:CD006065.
  2. You WC, Brown LM, Zhang L, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006;98:974-83.
  3. Evans V. Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use. J Neurosci Nurs 2000;32:229-32.
  4. Foster BC, Foster MS, Vandenhoek S, et al. An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic. J Pharm Pharmaceut Sci 2001;4:176-84.
  5. Carden SM, Good WV, Carden PA, Good RM. Garlic and the strabismus surgeon. Clin Experiment Ophthalmol 2002;30:303-4.
  6. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98.
  7. Gurley BJ, Gardner SF, Hubbard MA, et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002;72:276-87.
  8. Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther 2001;18:189-93.
  9. Durak I, Yilmaz E, Devrim E, et al. Consumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancer. Nutr Res 2003;23:199-204.
  10. Markowitz JS, Devane CL, Chavin KD, et al. Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clin Pharmacol Ther 2003;74:170-7.
  11. Suzuki H, Rhim JH. Effect of samgyetang feeding on plasma lipids, glucose, glycosylated hemoglobin, and stress-induced gastric ulcers in mice. Nutr Res 2000;20:575-84.
  12. Hsing AW, Chokkalingam AP, Gao YT, et al. Allium vegetables and risk of prostate cancer: a population-based study. J Natl Cancer Inst 2002;94:1648-51.
  13. Sheela CG, Kumud K, Augusti KT. Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats. Planta Med 1995;61:356-7.
  14. Bordia A, Verma SK, Srivastava KC. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1998;58:257-63.
  15. Sumioka I, Matsura T, Yamada K. Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice. Eur J Pharmacol 2001;433:177-85.
  16. Horie T, Awazu S, Itakura Y, Fuwa T. Alleviation by garlic of antitumor drug-induced damage to the intestine. J Nutr 2001;131:1071S-4S.
  17. Staba EJ, Lash L, Staba JE. A commentary on the effects of garlic extraction and formulation on product composition. J Nutr 2001;131:1118S-9S.
  18. Senapati SK, Dey S, Dwivedi SK, Swarup D. Effect of garlic (Allium sativum L.) extract on tissue lead level in rats. J Ethnopharmacol 2001;76:229-32.
  19. Ziaei S, Hantoshzadeh S, Rezasoltani P, Lamyian M. The effect of garlic tablet on plasma lipids and platelet aggregation in nulliparous pregnants at high risk of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2001;99:201-6.
  20. Lau BH. Suppression of LDL oxidation by garlic. J Nutr 2001;131:985S-8S.
  21. Yeh YY, Liu L. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr 2001;131:989S-93S.
  22. McHugh CP. Garlic as a tick repellent. JAMA 2001;285:41,42.
  23. Ledezma E, Marcano K, Jorquera A. Efficacy of ajoene in the treatment of tinea pedis: A double-blind and comparative study with terbinafine. J Am Acad Dermatol 2000;43:829-32.
  24. Lamm DL, Riggs DR. The potential application of Allium sativum (garlic) for the treatment of bladder cancer. Urol Clin North Am 2000;27:157-62.
  25. Ali M, Thomson M, Afzal M. Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance. Prostaglandins Leukot Essent Fatty Acids 2000;62:55-73.
  26. Piscitelli SC, Burstein AH, Welden N, et al. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis 2002;34:234-8.
  27. Ackermann RT, Mulrow CD, Ramirez G, et al. Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med 2001;161:813-24.
  28. Garlic: Effects on cardiovascular risks and disease, protective effects against cancer, and clinical adverse effects. Summary, evidence report/technol assessment: no 20. AHRQ Publ No. 01-E022, 2000;Oct. Agency for Healthcare Res and Quality. Rockville, MD.
  29. Stevinson C, Pittler MH, Ernst E. Garlic for treating hypercholesterolemia: a meta-analysis of randomized clinical trials. Ann Intern Med 2000;133:420-9.
  30. Lee TY, Lam TH. Contact dermatitis due to topical treatment with garlic in Hong Kong. Contact Dermatitis 1991;24:193-6.
  31. Cronin E. Dermatitis of the hands in caterers. Contact Dermatitis 1987;17:265-9.
  32. Mennella JA, Beauchamp GK. The effects of repeated exposure to garlic-flavored milk on the nursling's behavior. Pediatr Res 1993;34:805-8.
  33. Mennella JA, Beauchamp GK. Maternal diet alters the sensory qualities of human milk and the nursling's behavior. Pediatrics 1991;88:737-44.
  34. Mennella JA, Johnson A, Beauchamp GK. Garlic ingestion by pregnant women alters the odor of amniotic fluid. Chem Senses 1995;20:207-9.
  35. Anibarro B, Fontela JL, De La Hoz F. Occupational asthma induced by garlic dust. J Allergy Clin Immunol 1997;100:734-8.
  36. Ip C, Lisk DJ. Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium. Carcinogenesis 1995;16:2649-52.
  37. Dirsch VM, Kiemer AK, Wagner H, Vollmar AM. Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase. Atherosclerosis 1998;139:333-9.
  38. Pedraza-Chaverri J, Tapia E, Medina-Campos ON, et al. Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis. Life Sci 1998;62:71-7.
  39. Qureshi AA, Din ZZ, Abuirmeileh N, et al. Suppression of avian hepatic lipid metabolism by solvent extracts of garlic: impact on serum lipids. J Nutr 1983;113:1746-55.
  40. Gebhardt R, Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids 1996;31:1269-76.
  41. Jepson RG, Kleijnen J, Leng GC. Garlic for peripheral arterial occlusive disease (Cochrane Review). Cochrane Database Syst Rev 2000;:CD000095.
  42. Sasaki J, Kita T, Ishita K, et al. Antibacterial activity of garlic powder against Escherichia coli O-157. J Nutr Sci Vitaminol (Tokyo) 1999;45:785-90.
  43. Arora RC, Arora S. Comparative effect of clofibrate, garlic and onion on alimentary hyperlipemia. Atherosclerosis 1981;39:447-52.
  44. Morris J, Burke V, Mori TA, et al. Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study. Clin Exp Pharmacol Physiol 1995;22:414-7.
  45. Ali M, Bordia T, Mustafa T. Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation. Prostaglandins Leukot Essent Fatty Acids 1999;60:43-7.
  46. Legnani C, Frascaro M, Guazzaloca G, et al. Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects. Arzneimittelforschung 1993;43:119-22.
  47. Kiesewetter H, Jung F, Jung EM, et al. Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Eur J Clin Pharmacol 1993;45:333-6.
  48. Kiesewetter H, Jung F, Jung EM, et al. Effects of garlic coated tablets in peripheral arterial occlusive disease. Clin Investig 1993;71:383-6.
  49. Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications, 2000.
  50. Chutani SK, Bordia A. The effect of fried versus raw garlic on fibrinolytic activity in man. Atherosclerosis 1981;38:417-21.
  51. Koscielny J, Klussendorf D, Latza R, et al. The antiatherosclerotic effect of Allium sativum. Atherosclerosis 1999;144:237-49.
  52. Breithaupt-Grogler K, Ling M, Boudoulas H, Belz GG. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation 1997;96:2649-55.
  53. McCrindle BW, Helden E, Conner WT. Garlic extract therapy in children with hypercholesterolemia. Arch Pediatr Adolesc Med 1998;152:1089-94.
  54. Neil HA, Silagy CA, Lancaster T, et al. Garlic powder in the treatment of moderate hyperlipidaemia: a controlled trial and meta-analysis. J R Coll Physicians Lond 1996;30:329-34.
  55. Luley C, Lehmann-Leo W, Moller B, et al. Lack of efficacy of dried garlic in patients with hyperlipoproteinemia. Arzneimittelforschung 1986;36:766-8.
  56. Simons LA, Balasubramaniam S, von Konigsmark M, et al. On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. Atherosclerosis 1995;113:219-25.
  57. Superko HR, Krauss RM. Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a). J Am Coll Cardiol 2000;35:321-6.
  58. Kenzelmann R, Kade F. Limitation of the deterioration of lipid parameters by a standardized garlic-ginkgo combination product. A multicenter placebo-controlled double-blind study. Arzneimittelforschung 1993;43:978-81.
  59. Morcos NC. Modulation of lipid profile by fish oil and garlic combination. J Natl Med Assoc 1997;89:673-8.
  60. Adler AJ, Holub BJ. Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr 1997;65:445-50.
  61. Warshafsky S, Kamer RS, Sivak SL. Effect of garlic on total serum cholesterol. A meta-analysis. Ann Intern Med 1993;119:599-605.
  62. Vorberg G, Schneider B. Therapy with garlic: results of a placebo-controlled, double-blind study. Br J Clin Pract Symp Suppl 1990;69:7-11.
  63. Silagy C, Neil A. Garlic as a lipid lowering agent--a meta-analysis. J R Coll Physicians Lond 1994;28:39-45.
  64. Rotzsch W, Richter V, Rassoul F, Walper A. [Postprandial lipemia under treatment with Allium sativum. Controlled double-blind study of subjects with reduced HDL2-cholesterol]. Arzneimittelforschung 1992;42:1223-7.
  65. Mader FH. Treatment of hyperlipidaemia with garlic-powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Arzneimittelforschung 1990;40:1111-6.
  66. Jain AK, Vargas R, Gotzkowsky S, McMahon FG. Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med 1993;94:632-5.
  67. Holzgartner H, Schmidt U, Kuhn U. Comparison of the efficacy and tolerance of a garlic preparation vs. bezafibrate. Arzneimittelforschung 1992;42:1473-7.
  68. Mostafa MG, Mima T, Ohnishi ST, Mori K. S-allylcysteine ameliorates doxorubicin toxicity in the heart and liver in mice. Planta Med 2000;66:148-51.
  69. Dorant E, van den Brandt PA, Goldbohm RA. Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. Breast Cancer Res Treat 1995;33:163-70.
  70. Dorant E, van den Brandt PA, Goldbohm RA. A prospective cohort study on Allium vegetable consumption, garlic supplement use, and the risk of lung carcinoma in The Netherlands. Cancer Res 1994;54:6148-53.
  71. Key TJ, Silcocks PB, Davey GK, et al. A case-control study of diet and prostate cancer. Br J Cancer 1997;76:678-87.
  72. Takezaki T, Gao CM, Ding JH, et al. Comparative study of lifestyles of residents in high and low risk areas for gastric cancer in Jiangsu Province, China; with special reference to allium vegetables. J Epidemiol 1999;9:297-305.
  73. You WC, Blot WJ, Chang YS, et al. Allium vegetables and reduced risk of stomach cancer. J Natl Cancer Inst 1989;81:162-4.
  74. You WC, Zhang L, Gail MH, et al. Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer. Int J Epidemiol 1998;27:941-4.
  75. Dorant E, van den Brandt PA, Goldbohm RA. A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. Carcinogenesis 1996;17:477-84.
  76. Le Marchand L, Hankin JH, Wilkens LR, et al. Dietary fiber and colorectal cancer risk. Epidemiology 1997;8:658-65.
  77. Witte JS, Longnecker MP, Bird CL, et al. Relation of vegetable, fruit, and grain consumption to colorectal adenomatous polyps. Am J Epidemiol 1996;144:1015-25.
  78. Steinmetz KA, Kushi LH, Bostick RM, et al. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. Am J Epidemiol 1994;139:1-15.
  79. Weber ND, Andersen DO, North JA, et al. In vitro virucidal effects of Allium sativum (garlic) extract and compounds. Planta Med 1992;58:417-23.
  80. Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect 1999;1:125-9.
  81. Ledezma E, Lopez JC, Marin P, et al. Ajoene in the topical short-term treatment of tinea cruris and tinea corporis in humans. Randomized comparative study with terbinafine. Arzneimittelforschung 1999;49:544-7.
  82. Ledezma E, DeSousa L, Jorquera A, et al. Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis. Mycoses 1996;39:393-5.
  83. Calvet X, Carod C, Gene E. Re: Peppers at treatment for Helicobacter pylori infection. Am J Gastroenterol 2000;95:820-1.
  84. O'Gara EA, Hill DJ, Maslin DJ. Activities of Garlic Oil, Garlic Powder, and Their Diallyl Constituents against Helicobacter pylori. Appl Environ Microbiol 2000;66:2269-73.
  85. Aydin A, Ersoz G, Tekesin O, et al. Garlic oil and Helicobacter pylori infection. Am J Gastroenterol 2000;95:563-4.
  86. Ernst E. Is garlic an effective treatment for Helicobacter pylori infection? Arch Intern Med 1999;159:2484-5.
  87. Graham DY, Anderson SY, Lang T. Garlic or jalapeno peppers for treatment of Helicobacter pylori infection. Am J Gastroenterol 1999;94:1200-2.
  88. Steiner M, Li W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr 2001;131:980S-4S.
  89. O'Gara EA, Hill DJ, Maslin DJ. Activities of Garlic Oil, Garlic Powder, and Their Diallyl Constituents against Helicobacter pylori. Appl Environ Microbiol 2000;66:2269-73.
  90. Sato T, Miyata G. The Nutraceutical Benefit, Part IV: Garlic. Nutrition 2000;16:787-8.
  91. Fleischauer AT, Poole C, Arab L. Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. Am J Clin Nutr 2000;72:1047-52.
  92. Bloch AS. Pushing the Envelope of Nutrition Support: Complementary Therapies. Nutrition 2000;16:236-9.
  93. Stjernberg L, Berglund J. Garlic as an Insect Repellant. JAMA 2000;284:831.
  94. Fernandez-Vozmediano JM, Armario-Hita JC, Manrique-Plaza A. Allergic contact dermatitis from diallyl disulfide. Contact Dermatitis 2000;42:108-9.
  95. Siegel G, Klubendorf D. The anti-atherosclerotic effect of Allium sativum: Statistics re-evaluated. Atherosclerosis 2000;150:437-8.
  96. Zhang XH, Lowe D, Giles P, et al. Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. J Nutr 2001;131:1471-8.
  97. Rahman K, Billington D. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr 2000;130:2662-5.
  98. Horie T, Matsumoto H, Kasagi M, et al. Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration. Planta Med 1999;65:545-8.
  99. Gwilt PR, Lear CL, Tempero MA, et al. The effect of garlic extract on human metabolism of acetaminophen. Cancer Epidemiol Biomarkers Prev 1994;3:155-60.
  100. Wang BH, Zuzel KA, Rahman K, Billington D. Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices. Toxicology 1999;132:215-25.
  101. Zhang Y, Moriguchi T, Saito H, Nishiyama N. Functional relationship between age-related immunodeficiency and learning deterioration. Eur J Neurosci 1998;10:3869-75.
  102. Sigounas G, Hooker J, Anagnostou A, Steiner M. S-allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines. Nutr Cancer 1997;27:186-91.
  103. Ide N, Lau BH. Aged garlic extract attenuates intracellular oxidative stress. Phytomedicine 1999;6:125-31.
  104. Efendy JL, Simmons DL, Campbell GR, Campbell JH. The effect of the aged garlic extract, 'Kyolic', on the development of experimental atherosclerosis. Atherosclerosis 1997;132:37-42.
  105. Moriguchi T, Saito H, Nishiyama N. Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse. Biol Pharm Bull 1996;19:305-7.
  106. Imai J, Ide N, Nagae S, et al. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Med 1994;60:417-20.
  107. Lau BS, Lam F, Wang-Cheng R. Effect of an odor-modified garlic preparation on blood lipids. Nutr Res 1987;7:139-49.
  108. Steiner M, Lin RS. Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract. J Cardiovasc Pharmacol 1998;31:904-8.
  109. Steiner M, Khan AH, Holbert D, Lin RI. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr 1996;64:866-70.
  110. Ide N, Lau BH. Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. J Pharm Pharmacol 1997;49:908-11.
  111. Gurley BJ, Gardner SF, Hubbard MA. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. AAPS Ann Mtg & Expo Indianapolis, IN: 2000; Oct 29 - Nov 2:presentation #3460.
  112. Berthold HK, Sudhop T, von Bergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism. JAMA 1998;279:1900-2.
  113. Isaacsohn JL, Moser M, Stein EA, et al. Garlic powder and plasma lipids and lipoproteins, a multicenter, randomized, placebo-controlled trial. Arch Intern Med 1998;158:1189-94.
  114. Sunter WH. Warfarin and garlic. Pharm J 1991;246:722.
  115. Burnham BE. Garlic as a possible risk for postoperative bleeding. Plast Reconstr Surg 1995;95:213.
  116. Rose KD, et al. Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: a case report. Neurosurg 1990;26:880-2.
  117. Garty BZ. Garlic burns. Pediatrics 1993;91:658-9.
  118. Auer W, Eiber A, Hertkorn E, et al. Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Pract Suppl 1990;69:3-6.
  119. McMahon FG, Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 1993;13:406-7.
  120. Silagy CA, Neil HA. A meta-analysis of the effect of garlic on blood pressure. J Hypertens 1994;12:463-8.
  121. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Show more references
Show fewer references
Last reviewed - 12/24/2011




Page last updated: 06 September 2012