Distribution of water insertion and removal energies. (a) Distribution of removal energies
prem,1(Δ
U) (open squares) and insertion energies
pins,0(Δ
U) (circles), and reweighted distribution
(filled squares), obtained from amber03. (b) Logarithm of the ratio of the normalized distributions of insertion and removal energies for transitions between
N=0 and 1 (filled circles), 1 and 2 (filled squares), 2 and 3 (open squares), and 3 and 4 (open circles). Also shown are straight-line fits with fixed slope β, and intercept
.