Communities of Practice
- Expand ToxCast™ and determine a prospective assessment of the approach using chemicals currently entering a traditional testing process.
- Create a consolidated EPA exposure database focused on measured concentrations in exposure and biological media.
- Provide recommendations on the standards for exposure data representation.
- Recommend approaches for improving accessibility to EPA human exposure data and for facilitating links between exposure and toxicity data.
- Discuss novel approaches for characterizing exposure to prioritize chemicals.
EPA's Computational Toxicology Communities of Practice is composed of more than 300 people from over 50 public and private sector organizations who have an interest in encouraging computational toxicology usage and exposure science in helping to implement EPA's mission of protecting human health and the environment. Anyone can join the Communities of Practice and members include staff from EPA, other federal agencies, industry, academic institutions, professional societies, nongovernmental organizations, environmental non-profit groups, state environmental agencies and more.
Monthly meetings are held at EPA's RTP campus, on the fourth Thursday of the month, from 11am-Noon EST/EDT. Teleconferencing is available. Past Communities of Practice Presentations can be found here.
For more information or to be added to the meeting email list, contact Monica Linnenbrink at linnenbrink.monica@epa.gov or (919) 541-1522.
Goals:
- Develop key partnerships and collaborations with external groups that can facilitate the development of computational tools and exposure information needed to inform chemical prioritization.
- Review and provide expertise about the chemicals, assays, key target toxicities, data domains for ToxCast™ and how to incorporate chemical exposure into ToxCast™'s chemical screening project.
- Identify research needed to improve EPA's computational resources for addressing exposure screening and chemical prioritization.
- Determine the impact of metabolizing capability, or lack thereof, on the efficiency of the screening assays.
- Develop a bioinformatic approach to mining the resulting data and identifying signatures of concern.
- Report the utility of assay results and analysis techniques to categorize pilot chemicals according to known toxicity patterns; revise methods and approaches as dictated by results.
Computational Toxicology Presentation Files
- High-Resolution Metabolomics for Environmental Chemical Surveillance and Bioeffect Monitoring (Presented by: Dean Jones, PhD, Department of Medicine, Emory University) (2/28/2013). (pdf, 45 pp. 2.04 mb)
- Application of Computational Toxicology to Prospective and Diagnostic Ecological Risk Assessment (Presented by: Dan Villeneuve, Ph.D., Research Toxicologist, US-EPA Mid-Continent Ecology Division) (1/24/2013) (pdf, 50 pp. 4.27 mb)
- Translating Airway Gene Expression into Biomarkers for Tobacco Smoke Exposure and Lung Cancer Detection (Presented by: Avrum Spira, M.D., M.Sc., Boston University Medical Center) (12/13/2012) (pdf, 55 pp. 5.01 mb)
- CSS Dashboard (Presented by: Matthew Martin, PhD, National Center for Computational Toxicology, US EPA, RTP, NC) (11/15/2012) (pdf, 31 pp. 2.17 mb)
- Toxicity Screening using Zebrafish Embryos: Form and Function (Presented by: Stephanie Padilla, PhD, EPA Office of Research and Development, NHEERL) (9/27/2012) (pdf, 36 pp. 2.08 mb)
- Quantitative High Throughput Models for Exposure-Based Chemical Prioritization (Presented by: John Wambaugh, PhD, National Center for Computational Toxicology, US EPA, RTP, NC) (8/23/2012) (pdf, 28 pp. 1.47 mb)
- A freely-available, graphical user interface for ToxPi (Toxicological Prioritization Index) - (Presented by: Ivan Rusyn, MD, PhD, UNC and David Reif, PhD, EPA/NCCT) (7/26/2012).(pdf, 29 pp. 4.34 mb)
- State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet (Presented by Dr. Marilyn J. Aardema, Chief Scientific Advisor, Toxicology, Dr. Leon Stankowski, Principal Scientist/Program Consultant, and Ms. Kamala Pant, Principal Scientist, BioReliance (6/28/2012) (pdf, 55 pp. 1.05 mb)
- Development and Application of In Vitro Models for Screening Drugs and Environmental Chemicals that Predict Toxicity in Animals and Humans (Presented by James McKim, Ph.D., DABT, Founder and Chief Science Officer, CeeTox) (5/25/2012) (pdf, 49 pp. 4 mb)
- Discovering Environmental Causes of Disease: From Exposure Biology to the Exposome (Presented by Stephen M. Rappaport, Ph.D., University of California, Berkeley) (4/26/2012) (pdf, 35 pp. 5.22 mb)
- The Texas-Indiana Virtual STAR Center: Zebrafish Models for Developmental Toxicity Screening (Presented by Maria Bondesson Bolin, Ph.D, University of Houston, Center for Nuclear Receptors and Cell Signaling) (3/22/2012) (pdf, 48 pp. 3.2 mb)
- Predictive Hepatic Model Systems from Life Technologies: Strateties in Toxicology & Screening (Presented by Stephen Ferguson, Life Technologies) (1/26/2012) (pdf, 58 pp. 12.9 mb)
- Targeted Testing in Tox21, Michael DeVito, PhD, National Institute of Environmental Health Sciences (12/15/20110) (pdf, 36 pp. 1 mb)
- Vala Sciences Inc: Providing Innovative Strategies for High Content Imaging and Analysis (Presented by Patrick M. McDonough, PhD/VP of Biological Sciences, Vala Sciences Inc) (11/17/2011) (pdf, 30 pp. 28.4 mb)
- An Interactive Web Application for ToxPi, David M. Reif, PhD, EPA/NCCT (10/27/2011) (pdf, 296 pp. 3.15 mb)
- ExpoCastDB: A Publicly Accessible Database for Observational Exposure Data, Sumit Gangwal, PhD, EPA/NCCT (9/22/2011) (pdf, 26 pp. 3.25 mb)
- Computational Toxicology and Prenatal Development, Thomas B. Knudsen, PhD, EPA/NCCT (8/25/2011) (pdf, 25pp. 1.48 mb)
- Computational Toxicology and High-Throughput Risk Assessment, Richard Judson, EPA/NCCT (7/28/2011) (pdf, 27pp. 1.04 mb)
- Advancing the Next Generation of Risk Assessment, Ila Cote, EPA/NCEA (6/23/2011) (pdf, 26pp. 1.90 mb)
- Predictive Model of Reproductive Toxicity Using ToxCast High Throughput Screening, Matt Martin, EPA ORD (5/26/2011) (pdf, 22pp. 1.74 mb)
- EPA's Computational Toxicology Communities of Practice Series: Using Life Cycle Assessment for Risk Management, Mary Ann Curran, EPA/ORD (4/28/2011) (pdf, 22pp. 0.67 mb)
- NTP Workshop: Role of Environmental Chemicals in the Development of Diabetes and Obesity, Kris Thayer, NIEHS/NTP (3/24/2011) (pdf, 29pp. 1.54 mb)
- Chemical Safety for Sustainability: EPA Research to Meet 21st-Century Needs, Jeff Morris, US Environmental Protection Agency (2/24/2011) (pdf, 25pp. 1.60 mb)
- Experiencing REACH Exposure Assessments, Debbie Lander, E.I, DuPont de Nemours and Company (1/27/2011) (pdf, 16pp. 277 KB)
- Overview of ToxCast Phase II Chemicals, Ann Richard, Environmental Protection Agency (12/16/2010) (pdf, 32pp. 2.63 MB)
- Toxicant Analysis via High-content Screening of Cellular Circuits, John Westwick, Odyssey Thera (11/18/2010) (pdf, 23pp. 2.4 MB)
- Chemical Screening Visualization Tool: Resource for Rapid Chemical Assessment , Mario Chen, Dupont (10/28/2010) (pdf, 43pp. 1.6 MB)
- Comprehensive Exposure Narrative, Tom McKone, University of California Los Angeles School of Public Health (9/21/2010) (pdf, 20 pp. 3.3 MB)
- Risk Assessment of Chemicals and Prediction of Metabolism (08/26/2010) (pdf, 90 pp. 1.6 MB)
- Incorporating exposure information into Toxicological Priority Index (ToxPi) for Chemical Prioritization (7/22/2010) (pdf, 39 pp. 2.8 MB)
- ExpoCast™: Exposure Science for Prioritization and Toxicity Testing (06/24/2010) (pdf, 40 pp. 1.25 MB)
- Stemina Biomarker Discovery (3/25/10) (pdf, 33 pp. 4.45 MB)
- ER Expert System (2/24/10) (pdf, 46 pp. 0.28 MB)
- In ToxCast™ We Trust? (2/2/10) (pdf, 23 pp. 0.61 MB)
- Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast™ (pdf, 27 pp. 1.4 MB)
- Laying the Chemical Foundation for Tox21 & ToxCast™ (pdf, 33 pp. 0.9 MB)
- Improved quantitative models of chemical toxicity based on combined application of chemical and biological molecular descriptors HaoZhu and Alexander (09/24/09) (ppt, 50 pp. 2.1 MB)
- Developing Predictive Bioactivity Signatures of Carcinogenesis Using ToxCast HTS Data (09/14/09) (pdf, 31 pp. 1.53 MB)
- A Tiered Approach for the Use of Non-Testing Methods in the Regulatory Assessment of Chemicals (06/24/09) (ppt, 37 pp. 2.1 MB)
- The U.S. EPA's 2006 Inventory Update Reporting (IUR) Data on Chemical Substances (5/27/09) (pdf, 20 pp. 238 KB)
- Is ChAMP a Winning Strategy? (4/22/09) (pdf, 37 pp. 247 KB)
- The ToxCast 320 Chemical Library in Cultures of Primary Human Hepatocytes (11/18/08) (pdf, 40 pp. 4.04 MB)
- The ToxCast Chemical Universeand ACToR (10/17/08) (ppt, 23 pp. 1.34 MB)
- Screening for Chemical Effects on Neuronal Proliferation and Neurite Outgrowth Using High-Content/High-Throughput Microscopy (9/25/08) (pdf, 23 pp. 1.75 MB)
- Chemical Modulation of Gap Junctional Intercellular Communication in Toxicology (8/25/08) (pdf, 41 pp. 25.4 MB)
- Solidus Bioscience's MetaChip Technology for High- Throughput In Vitro Assessment of Chemical and Drug Candidate Toxicity (7/24/08) (pdf, 24 pp. 1.3 MB)
- U.S. EPA Use of QSAR and Category Approaches in Profiling Hazards of Industrial Chemicals (6/26/08) (pdf, 37 pp. 499 KB)
- Overview of the Contaminant Candidate List 3 (5/22/08) (pdf, 23 pp. 503 KB)
- Screening Chemicals in Commerce to Identify Possible Persistent and Bioaccumulative Chemicals: New Results and Future Work (04/24/08) (pdf, 27 pp. 211 KB)
- Chemical Prioritization and Risk Assessment in the 21st Century (03/27/08) (pdf, 31 pp., 1.4 MB)
- Collaboration on In Vitro Testing Proposal (02/28/08) (pdf, 37 pp., 6.8 MB)
- BioSeek ToxCast Presentation Summary (01/24/08) (pdf, 27 pp., 6.8 MB)
- Selection and Prioititzation of Chemicals for WA's Children's Saft Product Act (05/10/10) (ppt, 27 pp., 1.0 MB)
- Toxicological Priority Index (ToxPi) as aPlatform for Incorporation of Exposure Data for Chemical Prioritization (4/22/10) (ppt, 17 pp., 0.8 MB)
- ExpoCastTM: Exposure Science for Prioritization and Toxicity Testing (4/21/10) (ppt, 26 pp., 0.8 MB)
- Developing a FRAMES-Supported Environmental Fate Simulator: A Computational System for Estimating Environmental Concentrations of Organic Contaminants (2/08/09) (ppt, 24 pp., 2.28 MB)
- Translating Exposure Science for Decision-makers and the Informed Public: An Opportunity for Collaboration (1/11/09) (ppt, 17 pp., 1.58 MB)
- The Comparative Toxicogenomics Database (CTD): Predicting mechanisms of toxicity (ppt, 36 pp., 9.21 MB)
- Connecting Innovations in Biological, Exposure and Risk Sciences: Better Information for Better Decisions(ppt, 24 pp., 1.38 MB)
- Exposure Data Standards (ppt, 6 pp., 237 KB)
- Indoor Air Institute Workshop: SVOCs in the Indoor Environment (ppt, 28 pp., 1.6 MB)
- Prioritization in REACH (pdf, 32 pp., 166 KB)
- Exposure Science Research at the JRC Institute for Health and Consumer Protection (09/08/09) (pdf, 80 pp., 5.8 MB)
- Exposure Assessment for Chemicals Management (08/10/09) (pdf, 33 pp., 625 KB)
- Holistic Mass Balance Modeling Approach for Screening Chemical Inventories (07/14/09) (pdf, 50 pp., 425 KB)
- Connecting Environment, Biology, and Behavior for Human Exposure and Risk Assessment: Integrative Modeling Approaches (05/05/09) (pdf, 56 pp., 14.1 MB)
- GExFRAME A Web-Based Framework for Accessing Global Consumer Exposure Data, Scenarios, and Models (04/14/09) (pdf, 45 pp., 3.3 MB)
- Gene Expression Profiles: Biomarkers of Inter-Individual Susceptibility to Environmental Agents and Indicators of Exposure (03/10/09) (pdf, 109 pp., 3.9 MB)
- Biomonitoring Equivalents as Screening Tools for Interpretation of Human Biomonitoring Data (02/10/09) (pdf, 36 pp., 646 KB)
- Multimedia MultipathwayModeling of Emissions to Impacts: screening with USEtoxand advanced spatial modeling with IMPACT (01/13/09) (pdf, 36 pp., 3.2 MB)
- Prioritization of HPV Chemicals under the Chemical Assessment and Management Program (ChAMP) (12/08/08) (pdf, 39 pp., 387 KB)
- Assessing the Exposure-Dose-Toxicity Relationship within the EPA's ToxCast Program (11/04/08) (pdf, 36 pp., 2.1 MB)
- Chemical Exposure Priority Setting Tool (CEPST) (10/07/08) (pdf, 32 pp., 220 KB)
- Characterizing Exposure to Indoor VOCs and SVOCs using Simple Mass-Transfer Models (10/07/08) (pdf, 32 pp., 1 MB)
- European Centre for Ecotoxicology and Toxicology of Chemicals Targeted Risk Assessment (ECETOC TRA) Tool (09/09/08) (pdf, 37 pp., 1.24 MB)
- TOXICO-CHEMINFORMATICS: DSSTox and Chemical Structure Annotation for improved data access (08/12/08) (pdf, 62 pp., 3.7 MB)
- Considering Exposure in Priority Setting Categorization of the Domestic Substances List under the Canadian Environmental Protection Act (CEPA) (07/08/08) (pdf, 31 pp., 640 KB)
- Short Term Exposure Prioritization Needs for ToxCast (06/17/08 ) (pdf, 37 pp., 6.8 MB)
- Chemical Selection for ToxCast: EPA's Program for Predicting Toxicity and Prioritizing Chemical Testing (05/27/08) (pdf, 13 pp., 1.4 MB)