Reactome is a free, online, open-source, curated pathway database encompassing many areas of human biology.
Information is authored by expert biological researchers, maintained by the Reactome editorial staff and
cross-referenced to the NCBI Entrez Gene, Ensembl and
UniProt databases, the UCSC and
HapMap Genome Browsers, the KEGG
Compound and
ChEBI small molecule databases, PubMed, and
GO.
The curated human data are used to infer orthologous events
in 22 non-human species including mouse, rat, chicken, puffer fish, worm, fly, yeast, two plants and E.coli.
Tools for pathway analysis include Skypainter and Biomart.
Pathway data can be exported in SBML and BioPAX
formats.
A description of Reactome has been published in
Genome Biology and Nucleic Acids Research.
Protein-protein interaction datasets, statistics and the editorial calendar are available.
The Reactome team thanks users for their comments on the pathway analysis and pathway visualization tools.
Click on contact to reach us, on editorial to contribute to Reactome content,
and on subscribe to receive Reactome announcements.
Please take note of our disclaimer.
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- October 5, 2009 Dr. Elizabeth Blackburn, Reactome author, wins Nobel
Reactome congratulates Elizabeth H. Blackburn, 2009 Nobel laureate in Physiology or Medicine,
and thanks her again for her group's contributions to the Reactome Telomerase module. - September 30, 2009 Version 30 Released
Version 30 includes a new topic cell-cell adhesion systems with annotations of adherens junctions interactions and tight junction interactions.
Pathway topics revised and updated with new curated events in this release include downstream events in GPCR signaling and olfactory signaling, Costimulation by the CD28 family, SLC-mediated transmembrane transport of small molecules, Clathrin derived vesicle budding in membrane trafficking, signaling by Robo receptors in axon guidance
and gene expression (Nuclear Receptor pathway).
New metabolism topics include sphingolipid metabolism and three topics of special relevance to diabetes,
regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha (PPARalpha),
synthesis, secretion, and deacylation of ghrelin , and regulation of insulin secretion by free fatty acids. JW Akkerman,
JA Bluestone,
K Ebnet,
JH Esensten,
L Freedman,
YA Hannun,
L He,
T Kidd,
S Kersten,
H Kikutani,
A Kumanogoh,
V Poitout,
J Simpson,
L Vosshall, and
W Zhang
are our external reviewers in this release.
Reactome pathways are now available through NCBI BioSystems. Human protein-protein interaction data are now available for download in PSI-MITAB format.
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